Safety Findings of Dosing Gene Therapy Vectors in NHP With Pre-existing or Treatment-Emergent Anti-capsid Antibodies

Global seroprevalence of pre-existing immunity against AAV5 and other AAV serotypes in people with hemophilia A

(2022) Robert Klamroth et al.   HUMAN GENE THERAPY

Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause

(2022) Chayarani Kelgeri et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection

(2022) L. Helena Gutierrez Sanchez et al.   NEW ENGLAND JOURNAL OF MEDICINE

AAV and hepatitis: Cause or coincidence?

(2022) Ype P. de Jong et al.   MOLECULAR THERAPY

Validation of an IFN-gamma ELISpot assay to measure cellular immune responses against viral antigens in non-human primates

(2021) Fan Yang et al.   GENE THERAPY

Capsid-specific removal of circulating antibodies to adeno-associated virus vectors

(2020) Berangere Bertin et al.   Scientific Reports

IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies

(2020) Christian Leborgne et al.   NATURE MEDICINE

The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy

(2019) Brian R. Long et al.   Molecular Therapy-Methods & Clinical Development

Adeno-associated virus in the liver: natural history and consequences in tumour development

(2019) Tiziana La Bella et al.   GUT

Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

(2018) Christian Hinderer et al.   HUMAN GENE THERAPY

Influence of Pre-existing Anti-capsid Neutralizing and Binding Antibodies on AAV Vector Transduction

(2018) Zachary Fitzpatrick et al.   Molecular Therapy-Methods & Clinical Development

Variability of Spleen and Mesenteric Lymph Node in Control Cynomolgus Monkeys (Macaca fascicularis) from Nonclinical Safety Studies: A Retrospective Assessment

(2018) Nancy E. Everds et al.   TOXICOLOGIC PATHOLOGY

Strategy to detect pre-existing immunity to AAV gene therapy

(2017) L Falese et al.   GENE THERAPY

AAV: An Overview of Unanswered Questions

(2017) Kenneth I. Berns et al.   HUMAN GENE THERAPY

Overcoming the Host Immune Response to Adeno-Associated Virus Gene Delivery Vectors: The Race Between Clearance, Tolerance, Neutralization, and Escape

(2017) Federico Mingozzi et al.   Annual Review of Virology

Strategies to circumvent humoral immunity to adeno-associated viral vectors

(2015) Longping V Tse et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Preexisting Neutralizing Antibodies to Adeno-Associated Virus Capsids in Large Animals Other Than Monkeys May ConfoundIn VivoGene Therapy Studies

(2015) Roberto Calcedo et al.   Human Gene Therapy Methods

Neutralizing antibodies against AAV2, AAV5 and AAV8 in healthy and HIV-1-infected subjects in China: implications for gene therapy using AAV vectors

(2014) Q Liu et al.   GENE THERAPY

Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions

(2014) Etiena Basner-Tschakarjan et al.   Frontiers in Immunology

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

(2013) F. Mingozzi et al.   BLOOD

Histopathology of Incidental Findings in Cynomolgus Monkeys (Macaca Fascicularis) Used in Toxicity Studies

(2012) Junko Sato et al.   Journal of Toxicologic Pathology

Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia

(2011) C Li et al.   GENE THERAPY

Impact of Pre-Existing Immunity on Gene Transfer to Nonhuman Primate Liver with Adeno-Associated Virus 8 Vectors

(2011) Lili Wang et al.   HUMAN GENE THERAPY

Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

(2010) Sylvie Boutin et al.   HUMAN GENE THERAPY

Incidences and Range of Spontaneous Findings in Control Cynomolgus Monkeys (Macaca fascicularis) Used in Toxicity Studies

(2010) Ronnie Chamanza et al.   TOXICOLOGIC PATHOLOGY

AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

(2009) F. Mingozzi et al.   BLOOD

Immunity to adeno-associated virus vectors in animals and humans: a continued challenge

(2008) A K Zaiss et al.   GENE THERAPY