Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 5, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2014-07-23
DOI
10.3389/fimmu.2014.00350
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Computationally designed liver-specific transcriptional modules and hyperactive factor IX improve hepatic gene therapy
- (2014) N. Nair et al. BLOOD
- Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B
- (2014) Geoffrey L Rogers et al. Journal of Translational Medicine
- Neurotoxicity induced by antineoplastic proteasome inhibitors
- (2014) Albert Alé et al. NEUROTOXICOLOGY
- Immune Responses to AAV-Vectors, the Glybera Example from Bench to Bedside
- (2014) Valerie Ferreira et al. Frontiers in Immunology
- Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects
- (2014) Kai Gao et al. Molecular Therapy-Methods & Clinical Development
- Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype
- (2013) J. I. Siner et al. BLOOD
- Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells
- (2013) A. T. Martino et al. BLOOD
- Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant
- (2013) J. McIntosh et al. BLOOD
- Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies
- (2013) David M. Markusic et al. EMBO Molecular Medicine
- Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice
- (2013) Andrea Annoni et al. EMBO Molecular Medicine
- Gene therapy enters the pharma market: The short story of a long journey
- (2013) Hildegard Büning EMBO Molecular Medicine
- Prolonged Gene Expression in Muscle Is Achieved Without Active Immune Tolerance Using MicrorRNA 142.3p-Regulated rAAV Gene Transfer
- (2013) Florence Boisgerault et al. HUMAN GENE THERAPY
- Kinetics of Adeno-Associated Virus Serotype 2 (AAV2) and AAV8 Capsid Antigen Presentation In Vivo Are Identical
- (2013) Yi He et al. HUMAN GENE THERAPY
- Human Treg responses allow sustained recombinant adeno-associated virus–mediated transgene expression
- (2013) Christian Mueller et al. JOURNAL OF CLINICAL INVESTIGATION
- Adeno-associated virus capsid antigen presentation is dependent on endosomal escape
- (2013) Chengwen Li et al. JOURNAL OF CLINICAL INVESTIGATION
- CpG-depleted adeno-associated virus vectors evade immune detection
- (2013) Susan M. Faust et al. JOURNAL OF CLINICAL INVESTIGATION
- Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy
- (2013) Virginia Haurigot et al. JOURNAL OF CLINICAL INVESTIGATION
- Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes
- (2013) Daniel J Hui et al. MOLECULAR THERAPY
- CD8+ T Cell Recognition of Epitopes Within the Capsid of Adeno-associated Virus 8–based Gene Transfer Vectors Depends on Vectors’ Genome
- (2013) Te-Lang Wu et al. MOLECULAR THERAPY
- Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome
- (2013) A. Aiuti et al. SCIENCE
- Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy
- (2013) A. Biffi et al. SCIENCE
- Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys
- (2013) F. Mingozzi et al. Science Translational Medicine
- A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype
- (2013) Brian L Ellis et al. Virology Journal
- Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes
- (2013) Leslie P. Cousens et al. Journal of Diabetes Research
- Immunology of AAV-Mediated Gene Transfer in the Eye
- (2013) Keirnan Willett et al. Frontiers in Immunology
- Immunological Monitoring to Rationally Guide AAV Gene Therapy
- (2013) Cedrik Michael Britten et al. Frontiers in Immunology
- Humoral Immune Response to AAV
- (2013) Roberto Calcedo et al. Frontiers in Immunology
- Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice
- (2012) A. Cantore et al. BLOOD
- Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer
- (2012) G. Buchlis et al. BLOOD
- The efficacy and the risk of immunogenicity of FIX Padua (R338L) in hemophilia B dogs treated by AAV muscle gene therapy
- (2012) J. D. Finn et al. BLOOD
- A phase I trial of adeno-associated virus serotype 1-γ-sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C
- (2012) Serge Herson et al. BRAIN
- Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial
- (2012) D Gaudet et al. GENE THERAPY
- Immunodominant Liver-Specific Expression Suppresses Transgene-Directed Immune Responses in Murine Pompe Disease
- (2012) Ping Zhang et al. HUMAN GENE THERAPY
- -1 Antitrypsin Promotes Semimature, IL-10-Producing and Readily Migrating Tolerogenic Dendritic Cells
- (2012) E. Ozeri et al. JOURNAL OF IMMUNOLOGY
- Humoral and Cellular Capsid-Specific Immune Responses to Adeno-Associated Virus Type 1 in Randomized Healthy Donors
- (2012) P. Veron et al. JOURNAL OF IMMUNOLOGY
- Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates
- (2012) Carmen Unzu et al. Journal of Translational Medicine
- Importance of TAP-independent processing pathways
- (2012) Claudia C. Oliveira et al. MOLECULAR IMMUNOLOGY
- MyD88 Signaling in B Cells Regulates the Production of Th1-dependent Antibodies to AAV
- (2012) Muriel Sudres et al. MOLECULAR THERAPY
- Successful Regional Delivery and Long-term Expression of a Dystrophin Gene in Canine Muscular Dystrophy: A Preclinical Model for Human Therapies
- (2012) Zejing Wang et al. MOLECULAR THERAPY
- Long-Term Follow-Up After Gene Therapy for Canavan Disease
- (2012) P. Leone et al. Science Translational Medicine
- Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis
- (2012) Sander van der Marel WORLD JOURNAL OF GASTROENTEROLOGY
- The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver
- (2011) A. T. Martino et al. BLOOD
- Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents
- (2011) Roberto Calcedo et al. Clinical and Vaccine Immunology
- Immune Responses to AAV in Clinical Trials
- (2011) Federico Mingozzi et al. CURRENT GENE THERAPY
- Inflammation Promotes the Loss of Adeno-Associated Virus–Mediated Transgene Expression in Mouse Liver
- (2011) Ekaterina Breous et al. GASTROENTEROLOGY
- Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia
- (2011) C Li et al. GENE THERAPY
- Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors
- (2011) Marianna Hösel et al. HEPATOLOGY
- Mycophenolate Mofetil Impairs Transduction of Single-Stranded Adeno-Associated Viral Vectors
- (2011) Paula S. Montenegro-Miranda et al. HUMAN GENE THERAPY
- Phase 2 Clinical Trial of a Recombinant Adeno-Associated Viral Vector Expressing α1-Antitrypsin: Interim Results
- (2011) Terence R. Flotte et al. HUMAN GENE THERAPY
- Long-term Safety and Efficacy Following Systemic Administration of a Self-complementary AAV Vector Encoding Human FIX Pseudotyped With Serotype 5 and 8 Capsid Proteins
- (2011) Amit C Nathwani et al. MOLECULAR THERAPY
- Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges
- (2011) Federico Mingozzi et al. NATURE REVIEWS GENETICS
- Ex vivo gene transfer and correction for cell-based therapies
- (2011) Luigi Naldini NATURE REVIEWS GENETICS
- Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B
- (2011) Amit C. Nathwani et al. NEW ENGLAND JOURNAL OF MEDICINE
- Innate Immune Responses to AAV Vectors
- (2011) Geoffrey L. Rogers et al. Frontiers in Microbiology
- Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D
- (2010) Jerry R. Mendell et al. ANNALS OF NEUROLOGY
- Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B
- (2010) V. R. Arruda et al. BLOOD
- Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy
- (2010) J. D. Finn et al. BLOOD
- Codon optimization of human factor VIII cDNAs leads to high-level expression
- (2010) N. J. Ward et al. BLOOD
- Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond
- (2010) C. M. Britten et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
- (2010) William J Marks et al. LANCET NEUROLOGY
- Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs
- (2010) Virginia Haurigot et al. MOLECULAR THERAPY
- Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia
- (2010) Marina Cavazzana-Calvo et al. NATURE
- Dystrophin Immunity in Duchenne's Muscular Dystrophy
- (2010) Jerry R. Mendell et al. NEW ENGLAND JOURNAL OF MEDICINE
- A viral assembly factor promotes AAV2 capsid formation in the nucleolus
- (2010) F. Sonntag et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Limb-girdle muscular dystrophy type 2D gene therapy restores α-sarcoglycan and associated proteins
- (2009) Jerry R. Mendell et al. ANNALS OF NEUROLOGY
- AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells
- (2009) F. Mingozzi et al. BLOOD
- Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID Trial), a First-in-Human Phase 1/2 Clinical Trial
- (2009) Brian E. Jaski et al. JOURNAL OF CARDIAC FAILURE
- Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors
- (2009) Gary C. Pien et al. JOURNAL OF CLINICAL INVESTIGATION
- The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice
- (2009) Jiangao Zhu et al. JOURNAL OF CLINICAL INVESTIGATION
- Proteasome Inhibitors Decrease AAV2 Capsid derived Peptide Epitope Presentation on MHC Class I Following Transduction
- (2009) Jonathan D Finn et al. MOLECULAR THERAPY
- Lack of Immunotoxicity After Regional Intravenous (RI) Delivery of rAAV to Nonhuman Primate Skeletal Muscle
- (2009) Alice Toromanoff et al. MOLECULAR THERAPY
- Safety and tolerability of putaminal AADC gene therapy for Parkinson disease
- (2009) C. W. Christine et al. NEUROLOGY
- Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency
- (2009) Alessandro Aiuti et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity
- (2009) Ashley T. Martino et al. PLoS One
- Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy
- (2009) M. L. Brantly et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An experimental test of the independent action hypothesis in virus-insect pathosystems
- (2009) M. P. Zwart et al. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy
- (2009) N. Cartier et al. SCIENCE
- Intramuscular Administration of AAV1-Lipoprotein Lipase S447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients
- (2008) Erik S. Stroes et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy
- (2008) G. P. Niemeyer et al. BLOOD
- Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy
- (2008) V. M. Velazquez et al. BLOOD
- Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"
- (2008) A. S. De Groot et al. BLOOD
- Enhancing transduction of the liver by adeno-associated viral vectors
- (2008) A C Nathwani et al. GENE THERAPY
- Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis by CNS Administration of a Serotype 2 Adeno-Associated Virus Expressing CLN2 cDNA
- (2008) Stefan Worgall et al. HUMAN GENE THERAPY
- Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors
- (2008) A. K. Zaiss et al. JOURNAL OF VIROLOGY
- Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
- (2008) William J Marks et al. LANCET NEUROLOGY
- Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
- (2008) Albert M. Maguire et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis
- (2008) James W.B. Bainbridge et al. NEW ENGLAND JOURNAL OF MEDICINE
- Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses
- (2008) L. Zhong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics
- (2008) A. V. Cideciyan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More