From shape-shifting embryonic cells to oncology: The fascinating history of epithelial mesenchymal transition

Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo

(2023) Manli Chuai et al.   Science Advances

Computational modeling of TGF-β2:TβRI:TβRII receptor complex assembly as mediated by the TGF-β coreceptor betaglycan

(2023) Aasakiran Madamanchi et al.   BIOPHYSICAL JOURNAL

Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment

(2023) Ruiwen Ruan et al.   Molecular Cancer

TGF-β in developmental and fibrogenic EMTs

(2022) Jun Ho Lee et al.   SEMINARS IN CANCER BIOLOGY

Étienne Geoffroy Saint-Hilaire and the First Embryological Evolutionary Model on the Origin of Vertebrates

(2021) Andrés Galera   JOURNAL OF THE HISTORY OF BIOLOGY

Epithelial cell plasticity drives endoderm formation during gastrulation

(2021) Katharina Scheibner et al.   NATURE CELL BIOLOGY

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements

(2021) Shang-Min Zhang et al.   NATURE

Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate

(2020) Evan S. Bardot et al.   MECHANISMS OF DEVELOPMENT

TGFβ biology in cancer progression and immunotherapy

(2020) Rik Derynck et al.   Nature Reviews Clinical Oncology

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

(2020) Senem Aykul et al.   eLife

Cellular processes driving gastrulation in the avian embryo

(2020) Guillermo Serrano Nájera et al.   MECHANISMS OF DEVELOPMENT

Brachyury in the gastrula of basal vertebrates

(2020) Ashley E.E. Bruce et al.   MECHANISMS OF DEVELOPMENT

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

(2019) E. Dodagatta-Marri et al.   Journal for ImmunoTherapy of Cancer

Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition

(2019) Yoko Katsuno et al.   Science Signaling

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

(2019) Cornelia Kröger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMT and Cancer: More Than Meets the Eye

(2019) Rik Derynck et al.   DEVELOPMENTAL CELL

Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy

(2019) Rama Soundararajan et al.   Cancers

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

­­­Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia­­

(2017) Trinna L. Cuellar et al.   JOURNAL OF CELL BIOLOGY

TGF-β Family Signaling in Early Vertebrate Development

(2017) Joseph Zinski et al.   Cold Spring Harbor Perspectives in Biology

A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells

(2017) Justin M. David et al.   OncoImmunology

TGF-β Tumor Suppression through a Lethal EMT

(2016) Charles J. David et al.   CELL

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

(2016) Y. Lou et al.   CLINICAL CANCER RESEARCH

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

(2016) Jonathan M. L. Ostrem et al.   NATURE REVIEWS DRUG DISCOVERY

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Nodal·Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

(2014) Christophe Fuerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction

(2013) Intissar Akalay et al.   Autophagy

Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell-Mediated Lysis

(2013) I. Akalay et al.   CANCER RESEARCH

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

(2012) Sidong Huang et al.   CELL

TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

(2012) S. Lamouille et al.   JOURNAL OF CELL SCIENCE

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Transforming growth factor Beta2 is required for valve remodeling during heart development

(2011) Mohamad Azhar et al.   DEVELOPMENTAL DYNAMICS

Smad Signaling Is Required to Maintain Epigenetic Silencing during Breast Cancer Progression

(2010) P. Papageorgis et al.   CANCER RESEARCH

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Induction into the Hall of Fame: tracing the lineage of Spemann's organizer

(2008) R. Harland   DEVELOPMENT

Palatal seam disintegration: To die or not to die? that is no longer the question

(2008) Ali Nawshad   DEVELOPMENTAL DYNAMICS

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

(2008) N. Dumont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA