Computational modeling of TGF-β2:TβRI:TβRII receptor complex assembly as mediated by the TGF-β coreceptor betaglycan

Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling

(2021) Md. Shahriar Karim et al.   PLoS Computational Biology

TGF-β2 uses the concave surface of its extended finger region to bind betaglycan’s ZP domain via three residues specific to TGF-β and Inhibin-α

(2019) Morkos A. Henen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition

(2019) Jennifer J. Huang et al.   ONCOGENE

Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin

(2019) Sun Kyung Kim et al.   STRUCTURE

A window of opportunity for cooperativity in the T Cell Receptor

(2018) N. Martin-Blanco et al.   Nature Communications

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

(2017) Takako Saito et al.   Cell Reports

Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

(2016) Maria M. Villarreal et al.   BIOCHEMISTRY

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion

(2014) Jennifer L. Elderbroom et al.   MOLECULAR BIOLOGY OF THE CELL

Programming biological models in Python using PySB

(2013) C. F. Lopez et al.   Molecular Systems Biology

Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3)

(2013) Uschi Diestel et al.   PLoS One

Oligomeric interactions of TGF-β and BMP receptors

(2012) Marcelo Ehrlich et al.   FEBS LETTERS

Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily

(2012) Andrew P. Hinck   FEBS LETTERS

TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

(2011) Tao Huang et al.   EMBO JOURNAL

The T?R-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding

(2011) Jorge E. Zuniga et al.   JOURNAL OF MOLECULAR BIOLOGY

Secreted, receptor-associated bone morphogenetic protein regulators reduce stochastic noise intrinsic to many extracellular morphogen distributions

(2011) M. S. Karim et al.   Journal of the Royal Society Interface

Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-  binding

(2011) S. J. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily

(2010) Sergei Radaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Betaglycan has Two Independent Domains Required for High Affinity TGF-β Binding: Proteolytic Cleavage Separates the Domains and Inactivates the Neutralizing Activity of the Soluble Receptor

(2009) Valentín Mendoza et al.   BIOCHEMISTRY

TβR-II Discriminates the High- and Low-Affinity TGF-β Isoforms via Two Hydrogen-Bonded Ion Pairs†

(2009) Jason Baardsnes et al.   BIOCHEMISTRY

Quantitative Modeling and Analysis of the Transforming Growth Factor β Signaling Pathway

(2009) Seung-Wook Chung et al.   BIOPHYSICAL JOURNAL

The BMP-Binding Protein Crossveinless 2 Is a Short-Range, Concentration-Dependent, Biphasic Modulator of BMP Signaling in Drosophila

(2008) Mihaela Serpe et al.   DEVELOPMENTAL CELL

Analysis of Proteinase-activated Receptor 2 and TLR4 Signal Transduction

(2008) Prasad Rallabhandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system

(2008) B. Schmierer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA