Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

(2023) Yazhe Wang et al.   Science Advances

Intrathecal delivery and its applications in leptomeningeal disease

(2022) Minsoo Khang et al.   ADVANCED DRUG DELIVERY REVIEWS

Meningeal macrophages protect against viral neuroinfection

(2022) Julie Rebejac et al.   IMMUNITY

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

(2022) Antoine Drieu et al.   NATURE

An intrathecal limited postoperative chemotherapy regimen for the treatment of young children with nodular/desmoplastic medulloblastoma and medulloblastoma with extensive nodularity

(2021) Harrison Naung et al.   JOURNAL OF NEURO-ONCOLOGY

Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles

(2021) Jamie K. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized phase II trial of veliparib, radiotherapy and temozolomide in patients with unmethylated MGMT glioblastoma: the VERTU study

(2021) Hao-Wen Sim et al.   NEURO-ONCOLOGY

Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma

(2021) Jessica Buck et al.   Frontiers in Molecular Biosciences

Clearance of two organic nanoparticles from the brain via the paravascular pathway

(2020) Xiao Gu et al.   JOURNAL OF CONTROLLED RELEASE

Phase II study of reduced‐dose craniospinal irradiation and combination chemotherapy for children with newly diagnosed medulloblastoma: A report from the Japanese Pediatric Brain Tumor Consortium

(2020) Keiko Okada et al.   PEDIATRIC BLOOD & CANCER

Poly(ADP-ribose) polymerase inhibition: past, present and future

(2020) Nicola J. Curtin et al.   NATURE REVIEWS DRUG DISCOVERY

PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

(2019) Shiv K. Gupta et al.   Frontiers in Oncology

Biodistribution and Dosimetry of Intraventricularly Administered 124I-Omburtamab in Patients with Metastatic Leptomeningeal Tumors

(2019) Neeta Pandit-Taskar et al.   JOURNAL OF NUCLEAR MEDICINE

Nanoformulation of Talazoparib Increases Maximum Tolerated Doses in Combination With Temozolomide for Treatment of Ewing Sarcoma

(2019) Paige Baldwin et al.   Frontiers in Oncology

Crossing the blood-brain barrier with nanoparticles

(2018) Yiqun Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Differential patterns of metastatic dissemination across medulloblastoma subgroups

(2018) Michal Zapotocky et al.   Journal of Neurosurgery-Pediatrics

Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy

(2018) Yanxin Lu et al.   PHARMACOLOGY & THERAPEUTICS

PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow

(2018) Todd A. Hopkins et al.   MOLECULAR CANCER RESEARCH

A phase II study of radioimmunotherapy with intraventricular 131 I-3F8 for medulloblastoma

(2017) Kim Kramer et al.   PEDIATRIC BLOOD & CANCER

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Surface chemistry governs cellular tropism of nanoparticles in the brain

(2017) Eric Song et al.   Nature Communications

Poly-(ADP-ribose)-polymerase inhibitors as radiosensitizers: a systematic review of pre-clinical and clinical human studies

(2017) Paul Lesueur et al.   Oncotarget

Adjuvant Radiation Therapy Patterns and Survival Implications for Medulloblastoma in Young Children

(2016) B.H. Kann et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors

(2016) Jennifer K. Saucier-Sawyer et al.   JOURNAL OF CONTROLLED RELEASE

Survival After Relapse of Medulloblastoma

(2016) Carl Koschmann et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Improved i.p. drug delivery with bioadhesive nanoparticles

(2016) Yang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Systemic delivery of blood–brain barrier-targeted polymeric nanoparticles enhances delivery to brain tissue

(2015) Jennifer K. Saucier-Sawyer et al.   JOURNAL OF DRUG TARGETING

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

A sunblock based on bioadhesive nanoparticles

(2015) Yang Deng et al.   NATURE MATERIALS

A holistic approach to targeting disease with polymeric nanoparticles

(2015) Christopher J. Cheng et al.   NATURE REVIEWS DRUG DISCOVERY

Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System

(2015) Rishab Shyam et al.   Molecular Therapy-Nucleic Acids

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

(2015) Dannis Gilbert Van Vuurden et al.   Oncotarget

The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles

(2014) Yang Deng et al.   BIOMATERIALS

A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report†

(2014) Jack M. Su et al.   NEURO-ONCOLOGY

PLA-PEG-PLA copolymer-based polymersomes as nanocarriers for delivery of hydrophilic and hydrophobic drugs: preparation and evaluation with atorvastatin and lisinopril

(2013) H. Danafar et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma

(2013) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

PET imaging with 89Zr: From radiochemistry to the clinic

(2012) Melissa A. Deri et al.   NUCLEAR MEDICINE AND BIOLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo biodistribution and accumulation of 89Zr in mice

(2011) Diane S. Abou et al.   NUCLEAR MEDICINE AND BIOLOGY

Polylactide nanoparticles containing stably incorporated cyanine dyes for in vitro and in vivo imaging applications

(2010) Rong Tong et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Medulloblastoma in young children

(2010) Stefan Rutkowski et al.   PEDIATRIC BLOOD & CANCER

The Origins of Medulloblastoma Subtypes

(2008) Richard J. Gilbertson et al.   Annual Review of Pathology-Mechanisms of Disease

Particle size-dependent organ distribution of gold nanoparticles after intravenous administration

(2008) Wim H. De Jong et al.   BIOMATERIALS