Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease

Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

(2023) Martin Corcoran et al.   IMMUNITY

Normality sensing licenses local T cells for innate-like tissue surveillance

(2022) Duncan R. McKenzie et al.   NATURE IMMUNOLOGY

Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials

(2022) Geert D'Haens et al.   LANCET

Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19

(2022) Magdalene Joseph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granzyme K + CD8 T cells form a core population in inflamed human tissue

(2022) A. Helena Jonsson et al.   Science Translational Medicine

Intestinal barrier healing is superior to endoscopic and histologic remission for predicting major adverse outcomes in IBD: the prospective ERIca trial

(2022) Timo Rath et al.   GASTROENTEROLOGY

The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death

(2022) Yu Matsuzawa-Ishimoto et al.   NATURE

Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease

(2022) Nader Atlasy et al.   Nature Communications

Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets

(2021) Michael E.B. FitzPatrick et al.   Cell Reports

STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD

(2021) Dan Turner et al.   GASTROENTEROLOGY

Etrolizumab as induction and maintenance therapy for ulcerative colitis in patients previously treated with tumour necrosis factor inhibitors (HICKORY): a phase 3, randomised, controlled trial

(2021) Laurent Peyrin-Biroulet et al.   Lancet Gastroenterology & Hepatology

Etrolizumab for maintenance therapy in patients with moderately to severely active ulcerative colitis (LAUREL): a randomised, placebo-controlled, double-blind, phase 3 study

(2021) Severine Vermeire et al.   Lancet Gastroenterology & Hepatology

Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments

(2020) Anett Jandke et al.   Nature Communications

Colonic epithelial cell diversity in health and inflammatory bowel disease

(2019) Kaushal Parikh et al.   NATURE

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

(2019) Toufic Mayassi et al.   CELL

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

IBD prevalence in Lothian, Scotland, derived by capture–recapture methodology

(2019) Gareth-Rhys Jones et al.   GUT

Butyrophilin-like 3 Directly Binds a Human Vγ4+ T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen

(2019) Carrie R. Willcox et al.   IMMUNITY

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

Management Strategies to Improve Outcomes of Patients With Inflammatory Bowel Diseases

(2017) Jean-Frederic Colombel et al.   GASTROENTEROLOGY

Changes in Disease Behaviour and Location in Patients With Crohn’s Disease After Seven Years of Follow-Up: A Danish Population-based Inception Cohort

(2017) B Lo et al.   Journal of Crohns & Colitis

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

(2017) James C Lee et al.   NATURE GENETICS

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

(2017) Martin S. Davey et al.   Nature Communications

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

(2016) Rafael Di Marco Barros et al.   CELL

CD6 modulates thymocyte selection and peripheral T cell homeostasis

(2016) Marc Orta-Mascaró et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

(2016) Isabelle Cleynen et al.   LANCET

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

A common 56-kilobase deletion in a primate-specific segmental duplication creates a novel butyrophilin-like protein

(2013) Johanna Aigner et al.   BMC GENETICS

A Network of High-Mobility Group Box Transcription Factors Programs Innate Interleukin-17 Production

(2013) Nidhi Malhotra et al.   IMMUNITY

Comparative Study of Candidate Housekeeping Genes for Quantification of Target Gene Messenger RNA Expression by Real-Time PCR in Patients with Inflammatory Bowel Disease

(2013) Giorgos Bamias et al.   INFLAMMATORY BOWEL DISEASES

TLR4 Is a Novel Determinant of the Response to Paclitaxel in Breast Cancer

(2013) S. Rajput et al.   MOLECULAR CANCER THERAPEUTICS

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

(2013) Denise Gay et al.   NATURE MEDICINE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Chemokine Receptor CCR9 Is Required for the T-Cell–Mediated Regulation of Chronic Ileitis in Mice

(2011) Joshua D. Wermers et al.   GASTROENTEROLOGY

Skint-1 is a highly specific, unique selecting component for epidermal T cells

(2011) S. D. Barbee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

A common sequence motif associated with recombination hot spots and genome instability in humans

(2008) Simon Myers et al.   NATURE GENETICS

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

(2008) Michelle M. A. Fernando et al.   PLoS Genetics