In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

(2016) Kamel Mansouri et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Detection of thiol-based redox switch processes in parasites – facts and future

(2015) Mahsa Rahbari et al.   BIOLOGICAL CHEMISTRY

Mannich bases in medicinal chemistry and drug design

(2015) Gheorghe Roman   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diastereoselective Synthesis of 2,6-Diaryltetrahydrothiopyran-4-ones by Phase-Transfer Catalysis

(2015) Thibault Gendron et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Mappability of drug-like space: towards a polypharmacologically competent map of drug-relevant compounds

(2015) Pavel Sidorov et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Role and Regulation of Glutathione Metabolism in Plasmodium falciparum

(2015) Sylke Müller   MOLECULES

The Redox Systems of Plasmodium falciparum and Plasmodium vivax: Comparison, In silico Analyses and Inhibitor Studies

(2014) F. Mohring et al.   CURRENT MEDICINAL CHEMISTRY

Determination of antiplasmodial activity and binding affinity of curcumin and demethoxycurcumin towardsPfTrxR

(2014) Ranjith Munigunti et al.   NATURAL PRODUCT RESEARCH

The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis

(2013) Giuliana D. Noratto et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin-From Molecule to Biological Function

(2012) Tuba Esatbeyoglu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glutathione Transport: A New Role for PfCRT in Chloroquine Resistance

(2012) Eva-Maria Patzewitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin

(2012) Sunny Manohar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold

(2012) Claire-Lise Ciana et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

(2012) Shruti U Gandhy et al.   BMC CANCER

Curcumin enhances non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages

(2012) P. N. Mimche et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Versatile Synthesis of Dissymmetric Diarylideneacetones via a Palladium-Catalyzed­ Coupling–Isomerization Reaction

(2012) Thomas Müller et al.   SYNTHESIS-STUTTGART

LIBSVM

(2012) Chih-Chung Chang et al.   ACM Transactions on Intelligent Systems and Technology

Low-Molecular-Mass Antioxidants in Parasites

(2011) R. Luise Krauth-Siegel et al.   ANTIOXIDANTS & REDOX SIGNALING

Dibenzylideneacetone analogues as novel Plasmodium falciparum inhibitors

(2011) Rahul Balasaheb Aher et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

(2011) R. E. Carroll et al.   Cancer Prevention Research

A Novel Monocarbonyl Analogue of Curcumin, (1E,4E)-1,5-Bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one, Induced Cancer Cell H460 Apoptosis via Activation of Endoplasmic Reticulum Stress Signaling Pathway

(2011) Yi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial versus Cytotoxic Properties of Dual Drugs Derived From 4-Aminoquinolines and Mannich Bases: Interaction with DNA

(2010) Nicole I. Wenzel et al.   JOURNAL OF MEDICINAL CHEMISTRY

ISIDA Property-Labelled Fragment Descriptors

(2010) Fiorella Ruggiu et al.   Molecular Informatics

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Unsaturated Mannich Bases Active Against Multidrug-ResistantTrypanosoma brucei bruceiStrains

(2009) I. Nicole Wenzel et al.   ChemMedChem

Predicting the Predictability: A Unified Approach to the Applicability Domain Problem of QSAR Models

(2009) Horvath Dragos et al.   Journal of Chemical Information and Modeling

Recent Advances in the Discovery of Haem-Targeting Drugs for Malaria and Schistosomiasis

(2009) Katherine De Villiers et al.   MOLECULES

Identification of Proteins Targeted by the Thioredoxin Superfamily in Plasmodium falciparum

(2009) Nicole Sturm et al.   PLoS Pathogens

Synthesis and exploration of novel curcumin analogues as anti-malarial agents

(2008) Satyendra Mishra et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Sugar-Modified Phosphole Gold Complex with Antiproliferative Properties Acting as a Thioredoxin Reductase Inhibitor in MCF-7 Cells

(2008) Elodie Viry et al.   ChemMedChem

Antimalarial Dual Drugs Based on Potent Inhibitors of Glutathione Reductase fromPlasmodium falciparum

(2008) Wolfgang Friebolin et al.   JOURNAL OF MEDICINAL CHEMISTRY

The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase

(2008) Christophe Morin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY