Review
Chemistry, Organic
Shivani Gulati, Stephy Elza John, Nagula Shankaraiah
Summary: Microwave-assisted multicomponent reactions have become a useful tool in the synthesis of biologically relevant heterocycles, with enhanced yield and efficiency, reduced reaction time, high selectivity, and simpler purification techniques, which can accelerate the drug discovery process. This review focuses on recent advances in MWA-MCRs and their mechanistic insights over the past decade, highlighting their advantages over conventional approaches.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Kamal M. Dawood, Ashraf A. Abbas
Summary: This article thoroughly reports the synthetic routes to six differently connected bipyrazole systems, with a focus on cyclocondensation reactions and 1,3-dipolar cycloaddition reactions. Many of these bipyrazoles have potential applications in pharmaceutical and material science fields.
Article
Chemistry, Applied
David E. Scott, Mark D. Aloisio, Jose F. Rodriguez, Masato Morimoto, Robin J. Hamilton, Orain Brown, Rik R. Tykwinski, Jeffrey M. Stryker
Summary: This study found that catalytic iodine acts as a source of Bronsted acid in the presence of water, while generating iodonium ion and hydrogen peroxide to mediate the final oxidative aromatization step. Two independent catalytic cycles are driving the reaction, with complementary dual cycles working together to suppress side product formation and improve reaction efficiency.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Chemistry, Medicinal
Pedro Brandao, Carolina Marques, Anthony J. Burke, Marta Pineiro
Summary: Oxindole derivatives are known for their vast biological activities in Medicinal Chemistry. Recent studies on the preparation of oxindole derivatives using isatin-based multicomponent reactions have advanced the generation of druglike libraries with wide scaffold diversity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Kokila Sakthivel, R. J. Gana, Toshitaka Shoji, Naoko Takenaga, Toshifumi Dohi, Fateh V. Singh
Summary: This study demonstrates the effectiveness of metal catalysts in multicomponent reactions and provides an overview for their safe application in MCRs.
FRONTIERS IN CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Amol A. Nagargoje, Mubarak H. Shaikh, Bapurao B. Shingate
Summary: Curcumin, an important phytochemical found in Asian countries, has garnered interest from medicinal chemists worldwide for its potential use in the synthesis of curcumin-based heterocycles via multicomponent reactions (MCRs). This review focuses on the MCRs involving curcuminoids as reactants to synthesize curcumin-based heterocycles and discusses the pharmacological activities of these compounds. The review primarily examines research published in the last decade.
ARCHIV DER PHARMAZIE
(2023)
Article
Biochemistry & Molecular Biology
Costel Moldoveanu, Ionel Mangalagiu, Gheorghita Zbancioc
Summary: This study reports the synthesis and optical properties of new azasteroid derivatives, synthesized through 1,3-dipolar cycloaddition reactions. Under ultrasound irradiation, significantly higher yields were obtained with at least three times less solvent required. The azasteroid derivatives are blue emitters with distinct fluorescence properties.
Article
Chemistry, Analytical
Rui Wang, Dongyan Yang, Tian Tian, Yuhao An, Chuan Wan, Qi Chang, Mingchan Liang, Zhanfeng Hou, Ying Wang, Liang Zhang, Zigang Li
Summary: This study reports a set of cysteine-reactive sulfonium-based probes that can label reactive cysteine sites in cellular proteins. These water-soluble probes exhibit enhanced stability, specificity, and compatibility with quantitative proteomic profiling.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Mohammad Taghi Nazeri, Maryam Ghasemi, Masoomeh Ahmadi, Ahmad Shaabani, Behrouz Notash
Summary: By employing triazolobenzodiazepine as a cyclic imine, a variety of compounds can be synthesized under different reaction conditions, with mild conditions and high yields.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Mrityunjoy Datta
Summary: Recent advances in indium trichloride catalyzed synthesis of various organic compounds involve co-ordination with C-C and/or C-heteroatom multiple bonds and activation of oxiranes to produce aldehydes. This catalyst is used for multicomponent synthesis in both organic solvents and water, forming different heterocycles. Mechanisms of important reactions are discussed in detail, providing valuable information for readers.
Review
Biochemistry & Molecular Biology
Olga Bakulina, Anna Inyutina, Dmitry Dar'in, Mikhail Krasavin
Summary: This review summarizes recent developments in multicomponent reactions of diazo compounds, analyzing the role of diazo reagents and the type of interaction between components. In contrast to previous reviews mostly focused on metal catalyzed transformations, this work covers a substantial amount of organocatalytic or catalyst-free methodologies.
Article
Chemistry, Physical
Leonardo H. R. Alponti, Monize Picinini, Ernesto A. Urquieta-Gonzalez, Arlene G. Correa
Summary: This study utilized an ultra-stable Y zeolite as a catalyst to successfully synthesize a series of 1,4-dihydropyridines under microwave irradiation with high yields. The recovery and recycle of the USY zeolite were reported, along with its full characterization.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Chemistry, Organic
Qiang Yan, Rong Fan, Binbin Liu, Shuaisong Su, Bo Wang, Tuanli Yao, Jiajing Tan
Summary: Dearomatization reaction is a popular research area in organic chemistry, which can build highly functionalized three-dimensional molecules from aromatic compounds. This review discusses the mechanisms and various synthetic protocols of dearomatization reactions involving arynes, as well as provides insights and outlooks on this rapidly developing field.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yaojing Shi, Hua Zhao, Yufen Zhao
Summary: A microwave-promoted multicomponent reaction has been developed for the synthesis of oxygen-bridged spirooxindoles in good to excellent yields within 15 minutes under environmentally friendly conditions. The reaction shows high compatibility with various primary amino acids and exhibits efficient reaction time. The synthetic utility of spiropyrrolidine oxindole is further demonstrated through scale-up reaction and synthetic transformations. This work provides a powerful method to expand the structural diversity of spirooxindole as a promising scaffold for novel drug discovery.
Review
Chemistry, Physical
Thirupathi Damera, Ramakanth Pagadala, Surjyakanta Rana, Sreekantha Babu Jonnalagadda
Summary: Microwave energy has been fascinated as an alternative technique for the construction of heterocycles, with heterogeneous catalysts providing advantages in terms of recycling, catalyst preparation, and product yields. The usage of microwave energy has rapidly increased in various fields such as organic synthesis, peptide synthesis, polymer chemistry, material sciences, nanotechnology, and biological processes. This article covers the applications of microwave-assisted heterogeneous catalytic reactions in the construction of chromenes, pyridines, pyrroles, triazoles, pyrazoles, tetrazoles, trans and cis julolidines.
Article
Chemistry, Organic
Hamza Tachallait, Mohsine Driowya, Eleuterio Alvarez, Rachid Benhida, Khalid Bougrin
CURRENT ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Thomas Glachet, Hamid Marzag, Nathalie Saraiva Rosa, Johannes F. P. Colell, Guannan Zhang, Warren S. Warren, Xavier Franck, Thomas Theis, Vincent Reboul
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Medicinal
Etienne Brachet, Aurore Dumond, Wang-Qing Liu, Marie Fabre, Mohamed Selkti, Francoise Raynaud, Olivier Hermine, Rachid Benhida, Philippe Belmont, Christiane Garbay, Yves Lepelletier, Cyril Ronco, Gilles Pages, Luc Demange
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Physical
Dhaybia Douche, Hicham Elmsellem, El Hassane Anouar, Lei Guo, Baraa Hafez, Burak Tuzun, Ahmed El Louzi, Khalid Bougrin, Khalid Karrouchi, Banacer Himmi
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Chemistry, Organic
Kossi Efouako Soklou, Hamid Marzag, Jean-Philippe Bouillon, Mathieu Marchivie, Sylvain Routier, Karen Ple
Article
Chemistry, Multidisciplinary
Ayoub El Mahmoudi, Hamza Tachallait, Zakaria Moutaoukil, Suhana Arshad, Khalid Karrouchi, Rachid Benhida, Khalid Bougrin
Summary: This study successfully synthesized isoxazole-secondary sulfonamides through a one-pot five-component reaction. The use of ultrasound significantly improved the reaction efficiency, demonstrating the potential of ultrasound in organic synthesis.
Article
Agronomy
Ayoub El Mahmoudi, Rachida Fegrouche, Hamza Tachallait, Jean-Pierre Lumaret, Suhana Arshad, Khalid Karrouchi, Khalid Bougrin
Summary: To control the pest Sphodroxia maroccana Ley, researchers have developed a new class of insecticides. Through green synthesis, a series of novel isoxazoline-sulfonamide derivatives were obtained and their insecticidal activities against S. maroccana larvae were evaluated. Some of the derivatives showed higher insecticidal activity, laying the foundation for further discovery and development of isoxazoline-sulfonamide derivatives as novel crop protection larvicides of cork oak.
PEST MANAGEMENT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Oleksandr Grytsai, Oksana Valiashko, Manon Penco-Campillo, Maeva Dufies, Anais Hagege, Luc Demange, Sonia Martial, Gilles Pages, Cyril Ronco, Rachid Benhida
BIOORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Alberto Ongaro, Giovanni Ribaudo, Emmanuelle Braud, Melanie Etheve-Quelquejeu, Michele De Franco, Christiane Garbay, Luc Demange, Nohad Gresh, Giuseppe Zagotto
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
I Nounah, A. Hajib, A. Oubihi, H. Harhar, S. Gharby, B. Kartah, Z. Charrouf, K. Bougrin
MOROCCAN JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Hamza Tachallait, Mauro Safir Filho, Hamid Marzag, Khalid Bougrin, Luc Demange, Anthony R. Martin, Rachid Benhida
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Organic
Anthony Pesquet, Hamid Marzag, Michael Knorr, Carsten Strohmann, Ata Martin Lawson, Alina Ghinet, Joelle Dubois, Farce Amaury, Adam Daich, Mohamed Othman
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Review
Medicine, Research & Experimental
Maeva Dufies, Oleksandr Grytsai, Cyril Ronco, Oumar Camara, Damien Ambrosetti, Anais Hagege, Julien Parola, Lou Mateo, Marion Ayrault, Sandy Giuliano, Renaud Grepin, Nathalie Lagarde, Matthieu Montes, Patrick Auberger, Luc Demange, Rachid Benhida, Gilles Pages
