New Lupanes from Alstonia scholaris Reducing Uric Acid Level

Significant anti-inflammatory aziridine-containing indole alkaloids from the Chinese medicinal plant Alstonia scholaris

(2023) Bin-Yuan Hu et al.   CHEMICAL COMMUNICATIONS

Pharmacological investigation of indole alkaloids from Alstonia scholaris against chronic glomerulonephritis

(2023) Rui Guo et al.   PHYTOMEDICINE

Anti-hyperuricemic bioactivity of Alstonia scholaris and its bioactive triterpenoids in vivo and in vitro

(2022) Bin-Yuan Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

The clinical population pharmacokinetics, metabolomics and therapeutic analysis of alkaloids from Alstonia scholaris leaves in acute bronchitis patients

(2022) Rui Li et al.   PHYTOMEDICINE

Evaluation of Anti-urolithiatic Potential of Leaves of Alstonia scholaris and its Isolated Pentacyclic Triterpenoids in Ethylene Glycol-induced Renal Calculi Rat Model

(2021) Zehra Zehra S et al.   Indian Journal of Pharmaceutical Education and Research

The safety and tolerability of alkaloids from Alstonia scholaris leaves in healthy Chinese volunteers: a single-centre, randomized, double-blind, placebo-controlled phase I clinical trial

(2021) Zhong-Ping Gou et al.   PHARMACEUTICAL BIOLOGY

The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients

(2021) Won Jung Choi et al.   Journal of Clinical Medicine

Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of Alstonia scholaris

(2021) Bin-Yuan Hu et al.   ORGANIC LETTERS

Alstoscholarisine K, an Antimicrobial Indole from Gall-Induced Leaves of Alstonia scholaris

(2021) Hao-Fei Yu et al.   ORGANIC LETTERS

“Kidney Tea” and Its Bioactive Secondary Metabolites for Treatment of Gout

(2020) Wei-Di Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacological Effects of indole alkaloids from Alstonia scholaris (L.) R. Br. on pulmonary fibrosis in vivo

(2020) Yun-Li Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Natural products for the management of hyperuricaemia and gout: a review

(2019) Walid Hamdy El-Tantawy   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort

(2019) Toyoda et al.   Cells

Xanthium Orientale subsp. Italicum (Moretti) Greuter: bioassay-guided isolation and its chemical basis of antitumor cytotoxicity

(2019) Yuan He et al.   NATURAL PRODUCT RESEARCH

Triterpenoids from the barks of Juglans hopeiensis

(2019) Xiaogang Peng et al.   PHYTOCHEMISTRY

Lesinurad/Allopurinol (Duzallo) for Gout-Associated Hyperuricemia

(2018)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Actions of Inonotus obliquus against Hyperuricemia through XOD and Bioactives Screened by Molecular Modeling

(2018) Tianqiao Yong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Urate and osteoarthritis: Evidence for a reciprocal relationship

(2018) Tuhina Neogi et al.   JOINT BONE SPINE

Indole Alkaloids with New Skeleton Activating Neural Stem Cells

(2014) Xing-Wei Yang et al.   ORGANIC LETTERS

Three new triterpenoids from Salacia hainanensis Chun et How showed effective anti-α-glucosidase activity

(2012) Jian Huang et al.   Phytochemistry Letters

Decreased extra-renal urate excretion is a common cause of hyperuricemia

(2012) Kimiyoshi Ichida et al.   Nature Communications

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

(2011) Huaming Sheng et al.   NATURAL PRODUCT REPORTS

Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. growing in Egypt

(2011) Hesham I. El-Askary et al.   NATURAL PRODUCT RESEARCH

Gout

(2009) Pascal Richette et al.   LANCET

Efficient access to isomeric 2,3-dihydroxy lupanes: first synthesis of alphitolic acid

(2009) Jia Hao et al.   TETRAHEDRON

Uric Acid and Cardiovascular Risk

(2008) Daniel I. Feig et al.   NEW ENGLAND JOURNAL OF MEDICINE