Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology

Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: Systematic review and meta-analysis of randomized controlled trials

(2015) Surachai Kotirum et al.   COMPLEMENTARY THERAPIES IN MEDICINE

In VitroEvaluation of the Effects ofEurycoma longifoliaExtract on CYP-Mediated Drug Metabolism

(2015) Young Min Han et al.   Evidence-based Complementary and Alternative Medicine

Production of biomass and bioactive compounds from adventitious roots by optimization of culturing conditions of Eurycoma longifolia in balloon-type bubble bioreactor system

(2015) Tao Lulu et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

7-Methoxy-(9H-β-Carbolin-1-il)-(E)-1-Propenoic Acid, a β-Carboline Alkaloid FromEurycoma longifolia, Exhibits Anti-Inflammatory Effects by Activating the Nrf2/Heme Oxygenase-1 Pathway

(2015) Nguyen Hai Dang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Uncovering potential of Indonesian medicinal plants on glucose uptake enhancement and lipid suppression in 3T3-L1 adipocytes

(2015) Lucy Lahrita et al.   JOURNAL OF ETHNOPHARMACOLOGY

9-Hydroxycanthin-6-one, a β-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3β without Depending on Casein Kinase 1α

(2015) Kensuke Ohishi et al.   JOURNAL OF NATURAL PRODUCTS

Simultaneous quantitation of six major quassinoids in Tongkat Ali dietary supplements by liquid chromatography with tandem mass spectrometry

(2015) Young Min Han et al.   JOURNAL OF SEPARATION SCIENCE

Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp.

(2015) Sonal Girish et al.   Parasites & Vectors

Decreased expression of alpha-2-HS glycoprotein in the sera of rats treated with Eurycoma longifolia extract

(2015) Yeng Chen et al.   Frontiers in Pharmacology

The In Vitro and In Vivo Anti-Cancer Activities of a Standardized Quassinoids Composition from Eurycoma longifolia on LNCaP Human Prostate Cancer Cells

(2015) Kind Leng Tong et al.   PLoS One

Phytoandrogenic properties ofEurycoma longifoliaas natural alternative to testosterone replacement therapy

(2014) A. George et al.   ANDROLOGIA

Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia

(2014) SeonJu Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of potential anti-infectives against Staphylococcus aureus using a Caenorhabditis elegans infection model

(2014) Cin Kong et al.   BMC Complementary and Alternative Medicine

Effects of a Proprietary Freeze-Dried Water Extract ofEurycoma longifolia(Physta) andPolygonum minuson Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study

(2014) Jay K. Udani et al.   Evidence-based Complementary and Alternative Medicine

Rapid detection of sildenafil analogue in Eurycoma longifolia products using a new two-tier procedure of the near infrared (NIR) spectra database

(2014) Mazlina Mohd Said et al.   FOOD CHEMISTRY

NF-κB Inhibitors from Eurycoma longifolia

(2014) Thi Van Anh Tran et al.   JOURNAL OF NATURAL PRODUCTS

Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation

(2014) Shéhérazade Hajjouli et al.   MOLECULES

Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study

(2014) Omar Saeed Ali Al-Salahi et al.   PLoS One

In vivoeffects ofEurycoma longifoliaJack (Tongkat Ali) extract on reproductive functions in the rat

(2013) M. C. Solomon et al.   ANDROLOGIA

Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifoliaJack)

(2013) Ching-Hao Li et al.   Evidence-based Complementary and Alternative Medicine

Four new quassinoids from the roots of Eurycoma longifolia Jack

(2013) Dali Meng et al.   FITOTERAPIA

Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis

(2013) Bin-Seng Low et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro

(2013) Yan Pan et al.   Journal of Natural Medicines

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

(2013) Shawn M Talbott et al.   Journal of the International Society of Sports Nutrition

Anti-angiogenic quassinoid-rich fraction from Eurycoma longifolia modulates endothelial cell function

(2013) Omar Saeed Ali Al-Salahi et al.   MICROVASCULAR RESEARCH

Acute, Reproductive Toxicity and Two-generation Teratology Studies of a Standardized Quassinoid-rich Extract ofEurycoma longifoliaJack in Sprague-Dawley Rats

(2013) Bin-Seng Low et al.   PHYTOTHERAPY RESEARCH

Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study

(2013) Ralf R. Henkel et al.   PHYTOTHERAPY RESEARCH

In vitro Anti-proliferative and Apoptotic Activities of Eurycoma longifolia Jack (Simaroubaceae) on HL-60 Cell Line

(2013) OSA Al-Salahi et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Effect of Eurycoma longifolia Jack (Tongkat ali) extract on human spermatozoa in vitro

(2012) N. Erasmus et al.   ANDROLOGIA

Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model

(2012) Ahmad Nazrun Shuid et al.   BMC Complementary and Alternative Medicine

Respiratory Manifestations of Malaria

(2012) Walter R.J. Taylor et al.   CHEST

Quassinoids: From Traditional Drugs to New Cancer Therapeutics

(2012) G. Fiaschetti et al.   CURRENT MEDICINAL CHEMISTRY

Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract ofEurycoma longifoliafor the Improvement of Quality of Life and Sexual Well-Being in Men

(2012) Shaiful Bahari Ismail et al.   Evidence-based Complementary and Alternative Medicine

Combined Effects ofEurycoma longifoliaand Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model

(2012) Halimatun Saadiah Abdul Razak et al.   Evidence-based Complementary and Alternative Medicine

Eurycoma longifolia: Medicinal Plant in the Prevention and Treatment of Male Osteoporosis due to Androgen Deficiency

(2012) Nadia Mohd Effendy et al.   Evidence-based Complementary and Alternative Medicine

Malaria:

(2012) Behzad Nadjm et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Standardized quassinoid-rich Eurycoma longifolia extract improved spermatogenesis and fertility in male rats via the hypothalamic–pituitary–gonadal axis

(2012) Bin-Seng Low et al.   JOURNAL OF ETHNOPHARMACOLOGY

Oxidative Burst Inhibitory and Cytotoxic Activity of Constituents of the Fruits of Odyendyea gabonensis

(2012) Suzye Moladje Donkwe et al.   PLANTA MEDICA

The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats

(2012) Mahfoudh Abdulghani et al.   Reproductive Biology

Microsatellite markers of an important medicinal plant, Eurycoma longifolia (Simaroubaceae), for DNA profiling

(2011) L. H. Tnah et al.   AMERICAN JOURNAL OF BOTANY

Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism?

(2011) M. I. B. M. Tambi et al.   ANDROLOGIA

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

Acute and Subacute Toxicity Studies of Eurycoma longifolia in Male Rats

(2011) A.N. Shuid et al.   International Journal of Pharmacology

Developing a validated liquid chromatography–mass spectrometric method for the simultaneous analysis of five bioactive quassinoid markers for the standardization of manufactured batches of Eurycoma longifolia Jack extract as antimalarial medicaments

(2011) Chin-Hoe Teh et al.   JOURNAL OF CHROMATOGRAPHY A

LC–MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang)

(2011) Lee Suan Chua et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil. in animal models

(2011) Elisângela Saturnino de Souza Almeida et al.   JOURNAL OF ETHNOPHARMACOLOGY

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28

(2011) Pooi-Fong Wong et al.   PHYTOMEDICINE

Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene

(2011) Casimiro Cárdenas et al.   PLoS One

The anti-osteoporotic effect ofEurycoma Longifoliain aged orchidectomised rat model

(2010) Ahmad Nazrun Shuid et al.   Aging Male

Eurycoma longifolia Jack in managing idiopathic male infertility

(2010) Mohd Ismail Bin Mohd Tambi et al.   ASIAN JOURNAL OF ANDROLOGY

The effect of eurycoma longifolia jack on spermatogenesis in estrogen-treated rats

(2010) Norhazlina Abdul Wahab et al.   Clinics

Tongkat Ali (Eurycoma longifolia Jack): A review on its ethnobotany and pharmacological importance

(2010) Rajeev Bhat et al.   FITOTERAPIA

Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline

(2010) Shalender Bhasin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Modification of propranolol’s bioavailability by Eurycoma longifolia water-based extract

(2010) S. A. B. Salman et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Comparative X‐Ray and Conformational Analysis of a New Crystal of 13α,21-Dihydroeurycomanone with Eurycomanone fromEurycoma longifoliaand Their Anti-Estrogenic Activity Using the Uterotrophic Assay

(2010) Chin-Hoe Teh et al.   PLANTA MEDICA

Effects of Herbal Preparation on Libido and Semen Quality in Boars

(2010) S Frydrychová et al.   REPRODUCTION IN DOMESTIC ANIMALS

World Health Organization reference values for human semen characteristics*‡

(2009) Trevor G. Cooper et al.   HUMAN REPRODUCTION UPDATE

Clinical profile of dasatinib in Asian and non-Asian patients with chronic myeloid leukemia

(2009) Dong-Wook Kim et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals

(2009) N Qinna et al.   INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH

Liquid chromatography/tandem mass spectrometry studies of the phenolic compounds in honey

(2009) Magdalena Biesaga et al.   JOURNAL OF CHROMATOGRAPHY A

Influence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats

(2009) P. Zanoli et al.   JOURNAL OF ETHNOPHARMACOLOGY

Quassinoids fromEurycoma longifolia

(2009) Katsunori Miyake et al.   JOURNAL OF NATURAL PRODUCTS

Oxidative stress in bone remodelling and disease

(2009) Fabien Wauquier et al.   TRENDS IN MOLECULAR MEDICINE

Activity of Eurycoma longifolia root extract against Plasmodium falciparum in vitro

(2009) Walther H. Wernsdorfer et al.   WIENER KLINISCHE WOCHENSCHRIFT

Dysregulated angiogenesis in B-chronic lymphocytic leukemia: Morphologic, immunohistochemical, and flow cytometric evidence

(2008) John L Frater et al.   Diagnostic Pathology

Canthin-6-one alkaloids fromPicrasma quassioidesand their cytotoxic activity

(2008) Mei-Xiang Jiang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH