Letter
Medicine, General & Internal
Elzbieta Matujto-Balcerska, Kasper Sipowicz, Tadeusz Pietras
Summary: The levels of IL-1 beta and TNF-alpha were higher in COPD and depression patients compared to controls, while DIO2 levels were lower. These findings may explain the presence of depression in COPD patients.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Yun-Tian Chen, Kang Miao, Linfu Zhou, Wei-Ning Xiong
Summary: COPD, one of the most widespread chronic lung diseases globally, currently lacks effective treatments beyond symptom relief. Stem cell therapy shows promise in restoring lung function and improving quality of life for patients with COPD.
CHINESE MEDICAL JOURNAL
(2021)
Review
Microbiology
Jiexing Liu, Zhuonan Ran, Fen Wang, Caiyan Xin, Bin Xiong, Zhangyong Song
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airway limitation and persistent respiratory symptoms. Dysbiosis of pulmonary microbiota is believed to play a role in the pathogenesis of COPD, but research in this area is still in its early stages. Integrating data from various studies can enhance our understanding of the occurrence and progression of COPD and acute exacerbations.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Peter J. Barnes
Summary: Patients with COPD exhibit increased oxidative stress in their lungs, which can be caused by external factors such as smoking and air pollution, as well as internal factors such as inflammation. Oxidative stress plays a major role in driving the pathology of COPD, leading to chronic inflammation, cellular senescence, impaired autophagy, and reduced repair mechanisms. Antioxidants may be effective in modifying the disease progression of COPD.
Review
Biochemistry & Molecular Biology
Xiangming Ji, Hongwei Yao, Maureen Meister, Douglas S. Gardenhire, Huanbiao Mo
Summary: COPD is a leading cause of death worldwide, characterized by emphysema and chronic bronchitis, with smoking as a significant risk factor in developed countries. Chronic inflammation contributes to disease progression and comorbidities. Tocotrienols show potential as anti-inflammatory agents in COPD management.
Review
Biochemistry & Molecular Biology
Yue Yu, Ailin Yang, Ganggang Yu, Haoyan Wang
Summary: This review explores the relationship between ER stress and UPR with COPD, as well as drug intervention strategies targeting the UPR pathway in COPD. By analyzing other cellular processes, new therapeutic approaches and preventive measures for COPD are investigated.
Review
Medicine, General & Internal
Shouxiong Huang, Quan He, Linfu Zhou
Summary: This article critically reviews the activation, effector, and regulation of T cells in respiratory viral infections and chronic inflammations associated with COPD, highlighting the importance of crosstalk among T cells, innate immune cells, and airway epithelial cells in the pathogenesis of viral infections and COPD. It emphasizes the specificity of peptide antigens and the functional heterogeneity of conventional CD4(+) and CD8(+) T cells as potential targets for future development of therapeutics against respiratory viral infections and inflammations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Respiratory System
Siyuan Huang, Tao Feng, Jing Wang, Liang Dong
Summary: This study found that the level of IL-36 is positively correlated with the number of neutrophils in COPD patients but not with eosinophils, and the level of IL-36 is negatively correlated with lung function. Therefore, IL-36 may be a novel biomarker for determining COPD severity.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Immunology
Siqi Li, Qiong Huang, Dongbo Zhou, Baimei He
Summary: This review discusses the roles and mechanisms of PRKCD in the development of chronic obstructive pulmonary disease (COPD), suggesting that PRKCD contributes to COPD by promoting inflammatory response, apoptosis, mitochondrial dysfunction, and MUC5AC hypersecretion, and highlighting the potential of PRKCD as a therapeutic target for COPD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stanislav Kotlyarov
Summary: The research analyzed the important role of ABCA1 protein in the pathogenesis of COPD, with the expression of this protein in lung tissues playing a crucial role in lung function by participating in lipid metabolism, inflammation regulation, phagocytosis, and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yanhui Liu, Haobo Kong, Heping Cai, Guanru Chen, Huiying Chen, Wenyi Ruan
Summary: This paper reviews the association between the PI3K/Akt pathway and COPD, aiming to identify new therapeutic targets for clinical intervention in this disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Physiology
Xia Xu, Ke Huang, Fen Dong, Shiwei Qumu, Qichao Zhao, Hongtao Niu, Xiaoxia Ren, Xiaoying Gu, Tao Yu, Lin Pan, Ting Yang, Chen Wang
Summary: COPD is a heterogeneous disease with eosinophils potentially associated with emphysema, different from neutrophilic inflammation-related emphysema in small airway disease. The characterization of heterogeneity in COPD-associated inflammation may pave the way for personalized medicine and new therapeutic approaches.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Keru Qin, Baixue Xu, Min Pang, Hailong Wang, Baofeng Yu
Summary: This article reviews recent advances in understanding the roles of Th1/Th2 and Th17/Treg cells in the pathogenesis of chronic obstructive pulmonary disease (COPD) and discusses potential underlying mechanisms.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Immunology
Xiangming Liu, Yiming Ma, Lijuan Luo, Zihang Zeng, Dandan Zong, Yan Chen
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation and lung parenchymal cell apoptosis, with cigarette smoke being the major risk factor. In this study, taxifolin (TAX) was found to significantly alleviate cigarette smoke-induced inflammation and apoptosis in vivo and in vitro. TAX treatment suppressed the elevated levels of IL-1 beta, IL-6, and TNF-alpha, and decreased the ratios of p-i kappa B to i kappa B and p-p65 to p65. Additionally, TAX exhibited antiapoptotic effects by reversing the changes in Bax, CCP3, and Bcl-2 levels induced by cigarette smoke. These findings highlight the potential of TAX in improving COPD pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biology
Lukasz Mokros, Jacek Koprowicz, Piotr Leszczynski, Katarzyna Nowakowska-Domagala, Andrzej Witusik, Tadeusz Pietras
Summary: This study found that both chronotype and social jetlag may be useful predictors of certain aspects of burnout among physical therapists. Both chronotype and social jetlag should be considered together.
BIOLOGICAL RHYTHM RESEARCH
(2021)
Article
Nutrition & Dietetics
Michal Seweryn Karbownik, Joanna Kreczynska, Paulina Kwarta, Magdalena Cybula, Anna Wiktorowska-Owczarek, Edward Kowalczyk, Tadeusz Pietras, Janusz Szemraj
Article
Biology
Lukasz Mokros, Katarzyna Nowakowska-Domagala, Jacek Koprowicz, Andrzej Witusik, Tadeusz Pietras
Summary: This study found that somatic symptoms, anxiety/insomnia, and depressive symptoms fully mediate the relationship between chronotype and suicidality among students of the faculties of Medicine and Psychology, while social dysfunction, although associated with eveningness and suicidality, did not play a mediating role.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Review
Medicine, Research & Experimental
Marcin Kosmalski, Monika Rozycka-Kosmalska, Joanna Sikora, Tadeusz Pietras
Summary: Diabetes mellitus is not a single disease, but a group of diseases characterized by chronic hyperglycemia and risk of tissue and organ damage. The development of diabetes may be due to disorders of insulin secretion or its effects. Certain psychotropic medications can lead to a specific type of diabetes, and there is a bi-directional relationship between diabetes and psychiatric disorders.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2021)
Article
Psychiatry
Lukasz Mokros, Katarzyna Nowakowska-Domagala, Andrzej Witusik, Tadeusz Pietras
Summary: The aim of this study was to confirm the relationship between the severity of depressive symptoms, bipolar features, chronotype, and sleep quality among patients with major depressive disorder. The results showed that evening chronotype is related to bipolarity, independent of its link to depressive symptoms and sleep quality.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Environmental Sciences
Kasper Sipowicz, Marlena Podlecka, Lukasz Mokros, Tadeusz Pietras
Summary: The study found that elderly city residents had higher average levels of loneliness and depression, with living alone being the strongest predictor of both feelings. Sociodemographic status and somatic morbidities were significant factors in predicting loneliness and depressiveness scores in the elderly population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Kasper Sipowicz, Tadeusz Pietras, Marcin Kosmalski
Summary: Individuals with Asperger's syndrome without intellectual disabilities struggle to establish social relationships, leading to depression. This study investigates the correlation between loneliness, meaning in life dimensions, and depression severity among individuals with Asperger's syndrome and compares them with those without the syndrome and with healthy subjects. It is found that those with Asperger's syndrome and depression experience higher levels of loneliness and lower sense of meaning in life compared to other groups. Depression and Asperger's syndrome are associated with increased loneliness and reduced meaning in life.
SCIENTIFIC REPORTS
(2023)
Review
Psychiatry
Michal Sobstyl, Marek Prokopienko, Tadeusz Pietras
Summary: Deep brain stimulation is an experimental treatment for psychiatric disorders. Stimulating structures in the brain's reward circuit, such as the ventral striatum, may have antidepressant effects. Current studies suggest that the ventral striatum and visual cortex are promising targets for deep brain stimulation.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Elzbieta Malujlo-Balcerska, Tadeusz Pietras
Summary: This study evaluated the expression levels of certain molecules in patients with depressive disorders and controls. The results showed decreased expression of DIO2 and increased expression of IL1B, IL6, and TNFA in patients. Protein concentrations also showed corresponding changes. The AUC of IL-1 beta, IL-6, DIO1, and DIO3 proteins was >0.7, suggesting their potential as biomarkers for distinguishing patients with depressive disorders. Further studies are recommended to understand the exact role of these molecules.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Wojciech Lezak, Lukasz Mokros, Jakub M. Kazmierski, Dominik Strzelecki, Hanna Jerczynska, Edward Kowalczyk, Tadeusz Pietras
POSTEPY PSYCHIATRII I NEUROLOGII
(2020)
Article
Psychiatry
Malwina Soja, Wojciech Grabczak, Katarzyna Nowakowska-Domagala, Rafal Grabczak, Tadeusz Pietras, Lukasz Mokros
POSTEPY PSYCHIATRII I NEUROLOGII
(2020)
Article
Biochemistry & Molecular Biology
Joanna Sikora, Maria Podsiedlik, Tadeusz Pietras, Marcin Kosmalski, Mikolaj Matloka, Rafal Moszczynski-Petkowski, Maciej Wieczorek, Magdalena Markowicz-Piasecka
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2020)
Article
Allergy
Andrzej Witusik, Lukasz Mokros, Piotr Kuna, Tadeusz Pietras
POSTEPY DERMATOLOGII I ALERGOLOGII
(2020)
Article
Respiratory System
Andrzej Witusik, Lukasz Mokros, Janusz Szemraj, Piotr Kuna, Tadeusz Pietras
ADVANCES IN RESPIRATORY MEDICINE
(2020)
