Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments

CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6

(2021) Yohei Maruyama et al.   Communications Biology

The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization

(2021) Maryam Alqabandi et al.   BMC BIOLOGY

Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer

(2021) Naheed Arfin Borah et al.   MOLECULES

Aurora-B phosphorylates the myosin II heavy chain to promote cytokinesis

(2021) Aryeh Babkoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody

(2021) Chiara Merigliano et al.   PLoS Genetics

Cep55: abscission boss or assistant?

(2021) Jessica N. Little et al.   TRENDS IN CELL BIOLOGY

Silicon dioxide and titanium dioxide particles found in human tissues

(2020) Ruud J. B. Peters et al.   Nanotoxicology

Understanding the mechanisms of silica nanoparticles for nanomedicine

(2020) Ziyuan Li et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Toxic Impacts of Amorphous Silica Nanoparticles on Liver and Kidney of Male Adult Rats: an In Vivo Study

(2020) Rehab A. Azouz et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K

(2019) Herbert Sizek et al.   PLoS Computational Biology

Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery

(2019) Zhe Li et al.   Expert Opinion on Drug Delivery

Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

(2019) Elise Fouquerel et al.   MOLECULAR CELL

Silica nanoparticles induce autophagosome accumulation via activation of the EIF2AK3 and ATF6 UPR pathways in hepatocytes

(2018) Ji Wang et al.   Autophagy

ESCRT-dependent control of membrane remodelling during cell division

(2018) Caroline Louise Stoten et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Actin Cytoskeleton and Actin-Based Motility

(2018) Tatyana Svitkina   Cold Spring Harbor Perspectives in Biology

Nanoengineered silica: Properties, applications and toxicity

(2017) Andrea M. Mebert et al.   FOOD AND CHEMICAL TOXICOLOGY

Kinases Involved in Both Autophagy and Mitosis

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The ultrastructural organization of actin and myosin II filaments in the contractile ring: new support for an old model of cytokinesis

(2017) John H. Henson et al.   MOLECULAR BIOLOGY OF THE CELL

IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning

(2017) Nicolas Taulet et al.   Nature Communications

Interactions between Food Additive Silica Nanoparticles and Food Matrices

(2017) Mi-Ran Go et al.   Frontiers in Microbiology

Silica nanoparticles induce multinucleation through activation of PI3K/Akt/GSK-3β pathway and downregulation of chromosomal passenger proteins in L-02 cells

(2016) Weijia Geng et al.   JOURNAL OF NANOPARTICLE RESEARCH

The Internalization, Distribution, and Ultrastructure Damage of Silica Nanoparticles in Human Hepatic L-02 Cells

(2016) Yang Li et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Aberrant Cytokinesis and Cell Fusion Result in Multinucleation in HepG2 Cells Exposed to Silica Nanoparticles

(2015) Yongbo Yu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Regulation of cytokinesis and its clinical significance

(2015) Ana M. Tormos et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

(2015) Margaret M. Mc Gee   MEDIATORS OF INFLAMMATION

CYK4 Promotes Antiparallel Microtubule Bundling by Optimizing MKLP1 Neck Conformation

(2015) Tim Davies et al.   PLOS BIOLOGY

Gadolinium promoted proliferation in mouse embryo fibroblast NIH3T3 cells through Rac and PI3K/Akt signaling pathways

(2014) Liming Shen et al.   BIOMETALS

p38α deficiency and oxidative stress cause cytokinesis failure in hepatocytes

(2014) M. Tormos Ana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytoskeleton and Chromosome Damage Leading to Abnormal Mitosis Were Involved in Multinucleated Cells Induced by Silicon Nanoparticles

(2014) Yang Li et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Centralspindlin: At the heart of cytokinesis

(2012) Erin A. White et al.   Cytoskeleton

Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis

(2012) Virginia Silió et al.   MOLECULAR BIOLOGY OF THE CELL

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Long-Term Exposure to Silica Dust and Risk of Total and Cause-Specific Mortality in Chinese Workers: A Cohort Study

(2012) Weihong Chen et al.   PLOS MEDICINE

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes

(2011) Hiromi Nabeshi et al.   Particle and Fibre Toxicology

Aurora B and 14-3-3 Coordinately Regulate Clustering of Centralspindlin during Cytokinesis

(2010) Max E. Douglas et al.   CURRENT BIOLOGY

Nuclear Targeting of Gold Nanoparticles in Cancer Cells Induces DNA Damage, Causing Cytokinesis Arrest and Apoptosis

(2010) Bin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clustering of Centralspindlin Is Essential for Its Accumulation to the Central Spindle and the Midbody

(2009) Andrea Hutterer et al.   CURRENT BIOLOGY

Using carbon nanotubes to induce micronuclei and double strand breaks of the DNA in human cells

(2009) Jelena Cveticanin et al.   NANOTECHNOLOGY

Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure

(2009) Shing Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Midbody Targeting of the ESCRT Machinery by a Noncanonical Coiled Coil in CEP55

(2008) H. H. Lee et al.   SCIENCE