Manufacturing Process Development for the Biaryl Ether Fragment of Nemtabrutinib (MK-1026)

Integrating Process Development and Safety Analysis for Scale-Up of a Diborane-Generating Reduction Reaction

(2023) Brittany M. Armstrong et al.   Organic Process Research & Development

Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib

(2023) Yonggang Chen et al.   Organic Process Research & Development

Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib

(2023) Christopher K. Prier et al.   ACS Catalysis

Vision-Guided Automation Platform for Liquid–Liquid Extraction and Workup Development

(2023) Alexandra C. Sun et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene

(2022) Nadine Kuhl et al.   GREEN CHEMISTRY

Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO) III: Investigations Regarding the Main Decomposition

(2021) Yoshikuni Deguchi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO) II: Analysis of Intermediate Substances Obtained in the Induction Period and Investigations Regarding Formic Acid

(2021) Yoshikuni Deguchi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Potential Explosion Hazards Associated with the Autocatalytic Thermal Decomposition of Dimethyl Sulfoxide and Its Mixtures

(2020) Qiang Yang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Potential Safety Hazards Associated with Using N,N-Dimethylformamide in Chemical Reactions

(2020) Qiang Yang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Study on Autocatalytic Decomposition of Dimethyl Sulfoxide (DMSO)

(2020) Yoshikuni Deguchi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Potassium tert -Butoxide Prompted Highly Efficient Transamidation and Its Coordination Radical Mechanism

(2019) Zhiyong Tan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

KOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines

(2019) Tridev Ghosh et al.   ORGANIC LETTERS

Dimethyl carbonate: a versatile reagent for a sustainable valorization of renewables

(2018) G. Fiorani et al.   GREEN CHEMISTRY

The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

(2018) Sean D. Reiff et al.   Cancer Discovery

Metrics of Green Chemistry and Sustainability: Past, Present, and Future

(2017) Roger A. Sheldon   ACS Sustainable Chemistry & Engineering

Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors

(2015) Ahmed Z. Abdelazem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia

(2015) Jan A. Burger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia

(2014) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

(2013) J. A. Woyach et al.   BLOOD

Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies

(2012) Ranjana H. Advani et al.   JOURNAL OF CLINICAL ONCOLOGY

Complexity-Based Metric for Process Mass Intensity in the Pharmaceutical Industry

(2012) Douglas P. Kjell et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes

(2011) Concepcion Jimenez-Gonzalez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Understanding and Control of Dimethyl Sulfate in a Manufacturing Process: Kinetic Modeling of a Fischer Esterification Catalyzed by H2SO4

(2011) John P. Guzowski et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia

(2010) Graham Packham et al.   SEMINARS IN CANCER BIOLOGY

A Simple, Efficient, Green, Cost Effective and Chemoselective Process for the Esterification of Carboxylic Acids

(2009) Vamsi V. Rekha et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT