Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib

Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene

(2022) Nadine Kuhl et al.   GREEN CHEMISTRY

The Development of BTK Inhibitors: A Five-Year Update

(2021) Bruno Tasso et al.   MOLECULES

Evaluation of the carcinogenicity of dichloromethane in rats, mice, hamsters and humans

(2020) Wolfgang Dekant et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Synergistic Solvation Effects: Enhanced Compound Solubility Using Binary Solvent Mixtures

(2019) Jun Qiu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

(2018) Sean D. Reiff et al.   Cancer Discovery

The Halogen Bond

(2016) Gabriella Cavallo et al.   CHEMICAL REVIEWS

Updating and further expanding GSK's solvent sustainability guide

(2016) Catherine M. Alder et al.   GREEN CHEMISTRY

Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

(2013) J. A. Woyach et al.   BLOOD

The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia

(2010) Graham Packham et al.   SEMINARS IN CANCER BIOLOGY