Recent progress in regenerative therapy for damaged salivary glands: From bench to bedside

Immunomodulatory Macrophages Enable E-MNC Therapy for Radiation-Induced Salivary Gland Hypofunction

(2023) Ryo Honma et al.   Cells

Effective-mononuclear cell (E-MNC) therapy alleviates salivary gland damage by suppressing lymphocyte infiltration in Sjögren-like disease

(2023) Kayo Hasegawa et al.   Frontiers in Bioengineering and Biotechnology

Marrow-Derived Autologous Stromal Cells for the Restoration of Salivary Hypofunction (MARSH): Study protocol for a phase 1 dose-escalation trial of patients with xerostomia after radiation therapy for head and neck cancer

(2022) Grace C. Blitzer et al.   CYTOTHERAPY

Intraglandular Off-the-Shelf Allogeneic Mesenchymal Stem Cell Treatment in Patients with Radiation-Induced Xerostomia: A Safety Study (MESRIX-II)

(2022) Charlotte Duch Lynggaard et al.   Stem Cells Translational Medicine

Human Bone Marrow Cell Extracts Mitigate Radiation Injury to Salivary Gland

(2022) X. Su et al.   JOURNAL OF DENTAL RESEARCH

Mesenchymal stromal cell extracellular vesicles for multiple sclerosis in preclinical rodent models: A meta-analysis

(2022) Chengfeng Xun et al.   Frontiers in Immunology

Labial Stem Cell Extract Mitigates Injury to Irradiated Salivary Glands

(2020) X. Su et al.   JOURNAL OF DENTAL RESEARCH

Sphingosine‐1‐phosphate alleviates irradiation‐induced parotid injury in a miniature pig model

(2020) Wen Pan et al.   ORAL DISEASES

Phase 1 clinical study of cell therapy with effective-mononuclear cells (E-MNC) for radiogenic xerostomia (first-in-human study) (FIH study on E-MNC therapy for radiogenic xerostomia)

(2020) Yoshinori Sumita et al.   MEDICINE

CERE-120 prevents irradiation-induced hypofunction and restores immune homeostasis in porcine salivary glands.

(2020) Isabelle M.A. Lombaert et al.   Molecular Therapy-Methods & Clinical Development

Immunomodulatory Effects of Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Extracellular Vesicles in Rheumatoid Arthritis

(2020) Huan Liu et al.   Frontiers in Immunology

Mesenchymal Stem Cells Extract (MSCsE)-Based Therapy Alleviates Xerostomia and Keratoconjunctivitis Sicca in Sjogren’s Syndrome-Like Disease

(2019) Ghada Abughanam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safety and Efficacy of Mesenchymal Stem Cells for Radiation-Induced Xerostomia: A Randomized, Placebo-Controlled Phase 1/2 Trial (MESRIX)

(2018) Christian Grønhøj et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Neurturin Gene Therapy Protects Parasympathetic Function to Prevent Irradiation-Induced Murine Salivary Gland Hypofunction

(2018) Joao N.A. Ferreira et al.   Molecular Therapy-Methods & Clinical Development

Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model

(2018) Liang Hu et al.   Theranostics

Cell extracts from spleen and adipose tissues restore function to irradiation-injured salivary glands

(2017) Dongdong Fang et al.   Journal of Tissue Engineering and Regenerative Medicine

Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction

(2016) I Alevizos et al.   GENE THERAPY

Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands

(2016) Sarah Pringle et al.   STEM CELLS

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases

(2015) Michele W L Teng et al.   NATURE MEDICINE

The potential use of cell-based therapies in the treatment of oral diseases

(2015) H Kagami   ORAL DISEASES

Adipose Mesenchymal Stem Cell Secretome Modulated in Hypoxia for Remodeling of Radiation-Induced Salivary Gland Damage

(2015) Hye-Young An et al.   PLoS One

Treatment for salivary gland hypofunction at both initial and advanced stages of Sjögren-like disease: a comparative study of bone marrow therapy versus spleen cell therapy with a 1-year monitoring period

(2014) Saeed Khalili et al.   CYTOTHERAPY

Shear stress and VEGF enhance endothelial differentiation of human adipose-derived stem cells

(2014) Francesca Colazzo et al.   GROWTH FACTORS

Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem Cells

(2014) Lalitha S.Y. Nanduri et al.   Stem Cell Reports

Paracrine Effects of Bone Marrow Soup Restore Organ Function, Regeneration, and Repair in Salivary Glands Damaged by Irradiation

(2013) Simon D. Tran et al.   PLoS One

Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland

(2013) Lalitha S.Y. Nanduri et al.   RADIOTHERAPY AND ONCOLOGY

Salivary gland development: A template for regeneration

(2013) Vaishali N. Patel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Parasympathetic stimulation improves epithelial organ regeneration

(2013) Sarah M. Knox et al.   Nature Communications

Functional salivary gland regeneration by transplantation of a bioengineered organ germ

(2013) Miho Ogawa et al.   Nature Communications

Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies

(2013) David Hebbelstrup Jensen et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

The role of mesenchymal stem cells in cancer development

(2013) Hiroshi Yagi et al.   Frontiers in Genetics

Intraglandular transplantation of bone marrow-derived clonal mesenchymal stem cells for amelioration of post-irradiation salivary gland damage

(2012) Jae-Yol Lim et al.   ORAL ONCOLOGY

Mesenchymal Stromal Cells Improve Salivary Function and Reduce Lymphocytic Infiltrates in Mice with Sjögren's-Like Disease

(2012) Saeed Khalili et al.   PLoS One

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction

(2012) B. J. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraoral electrostimulator for xerostomia relief: a long-term, multicenter, open-label, uncontrolled, clinical trial

(2012) Ivan Alajbeg et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Matrigel improves functional properties of human submandibular salivary gland cell line

(2011) Ola M. Maria et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regeneration of radiation damaged salivary glands with adipose-derived stromal cells

(2011) Tsuyoshi Kojima et al.   LARYNGOSCOPE

Bone marrow cells are a source of undifferentiated cells to prevent Sjögren's syndrome and to preserve salivary glands function in the non-obese diabetic mice

(2010) Saeed Khalili et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation

(2010) Yoshinori Sumita et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Bone marrow-derived cells: A potential approach for the treatment of xerostomia

(2010) Simon D. Tran et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Concise Review: Dissecting a Discrepancy in the Literature: Do Mesenchymal Stem Cells Support or Suppress Tumor Growth?

(2010) Ann H. Klopp et al.   STEM CELLS

Matrigel Improves Functional Properties of Primary Human Salivary Gland Cells

(2010) Ola M. Maria et al.   TISSUE ENGINEERING PART A

Development of a gene transfer-based treatment for radiation-induced salivary hypofunction

(2009) Bruce J. Baum et al.   ORAL ONCOLOGY

Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation

(2009) Jielin Feng et al.   RADIOTHERAPY AND ONCOLOGY

Rescue of Salivary Gland Function after Stem Cell Transplantation in Irradiated Glands

(2008) Isabelle M. A. Lombaert et al.   PLoS One