Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells

Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism

(2023) Vanessa Delcroix et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation

(2022) Olivier Mauduit et al.   Frontiers in Immunology

Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface

(2022) Menglu Yang et al.   BMC Ophthalmology

Circulating Free DNA and Its Emerging Role in Autoimmune Diseases

(2021) Patricia Mondelo-Macía et al.   Journal of Personalized Medicine

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

(2020) Yi Zhou et al.   IMMUNITY

Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease

(2020) Laura García-Posadas et al.   AMERICAN JOURNAL OF PATHOLOGY

RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells

(2020) Menglu Yang et al.   Ocular Surface

Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity

(2020) Christopher J.A. Duncan et al.   TRENDS IN GENETICS

Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity

(2020) Ayesha Zahid et al.   Frontiers in Immunology

Sjögrenʼs Syndrome

(2019) Esen K. Akpek et al.   CORNEA

STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

(2019) Sabrina L. Ergun et al.   CELL

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus

(2018) Yasuhiro Kato et al.   ANNALS OF THE RHEUMATIC DISEASES

Systemic activation of NLRP3 inflammasome in patients with severe primary Sjögren's syndrome fueled by inflammagenic DNA accumulations

(2018) Aigli G. Vakrakou et al.   JOURNAL OF AUTOIMMUNITY

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

(2017) Jérôme Lugrin et al.   IMMUNOLOGICAL REVIEWS

Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment

(2017) Tim Both et al.   International Journal of Medical Sciences

Autoantibodies in Sjögren’s Syndrome

(2016) Anum Fayyaz et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Human TBK1: A Gatekeeper of Neuroinflammation

(2016) Liyana Ahmad et al.   TRENDS IN MOLECULAR MEDICINE

Breaching the nuclear envelope in development and disease

(2014) Emily Hatch et al.   JOURNAL OF CELL BIOLOGY

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired Clearance of Early Apoptotic Cells Mediated by Inhibitory IgG Antibodies in Patients with Primary Sjögren's Syndrome

(2014) Menelaos N. Manoussakis et al.   PLoS One

Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures

(2014) Laurent Chiche et al.   Arthritis & Rheumatology

The origin and properties of extracellular DNA: From PAMP to DAMP

(2012) David S. Pisetsky   CLINICAL IMMUNOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Neural regulation of lacrimal gland secretory processes: Relevance in dry eye diseases

(2009) Darlene A. Dartt   PROGRESS IN RETINAL AND EYE RESEARCH