Antidepressant-like effects of tomatidine and tomatine, steroidal alkaloids from unripe tomatoes, via activation of mTORC1 in the medial prefrontal cortex in lipopolysaccharide-induced depression model mice

Intranasal Administration of Resolvin E1 Produces Antidepressant-Like Effects via BDNF/VEGF-mTORC1 Signaling in the Medial Prefrontal Cortex

(2023) Satoshi Deyama et al.   Neurotherapeutics

IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine

(2022) Satoshi Deyama et al.   Translational Psychiatry

Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine

(2022) Satoshi Deyama et al.   NEUROPHARMACOLOGY

Resolvins as potential candidates for the treatment of major depressive disorder

(2021) Satoshi Deyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Lipopolysaccharide-induced depression is associated with estrogen receptor-α/SIRT1/NF-κB signaling pathway in old female mice

(2021) Xi Jiang et al.   NEUROCHEMISTRY INTERNATIONAL

The antidepressant-like effect of resolvin E1 in repeated prednisolone-induced depression model mice

(2021) Shun Aoki et al.   BEHAVIOURAL BRAIN RESEARCH

Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation

(2021) Katarzyna M. Targowska-Duda et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The steroidal alkaloids α-tomatine and tomatidine: Panorama of their mode of action and pharmacological properties

(2021) Christian Bailly   STEROIDS

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

(2020) Chadi G. Abdallah et al.   NEUROPSYCHOPHARMACOLOGY

Effects of vitamin D supplementation on depression and some involved neurotransmitters

(2020) Mina Kaviani et al.   JOURNAL OF AFFECTIVE DISORDERS

Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats

(2020) Xiangyu Chu et al.   Aging-US

Over-expression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy

(2020) Joseph J. Bass et al.   Molecular Metabolism

The duration of the antidepressant-like effects of a single infusion of brain-derived neurotrophic factor into the medial prefrontal cortex in mice

(2020) Satoshi Deyama et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective effects of vitamin D and 17ß-estradiol against ovariectomy-induced neuroinflammation and depressive-like state: Role of the AMPK/NF-κB pathway

(2020) Wen-yuan Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Vitamin D3/vitamin D receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal BDNF expression

(2020) Yunxuan Xu et al.   NEUROSCIENCE RESEARCH

Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine

(2019) Satoshi Deyama et al.   AMERICAN JOURNAL OF PSYCHIATRY

Effects of the synthetic cannabinoid 5F-AMB on anxiety and recognition memory in mice

(2019) Shiho Ito et al.   PSYCHOPHARMACOLOGY

Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

(2019) Taro Kato et al.   JOURNAL OF CLINICAL INVESTIGATION

Insomnia and depressive symptoms during the menopausal transition: theoretical and therapeutic implications of a self-reinforcing feedback loop

(2019) Danila Caruso et al.   MATURITAS

Tomatidine Reduces Palmitate‐Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor‐Mediated Signaling in Human HepG2 Hepatocytes

(2019) Hikari Kusu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants

(2019) Ronald S. Duman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine

(2019) Satoshi Deyama et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice

(2018) Sami Alzarea et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

(2018) Satoshi Deyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neurotrophic and Antidepressant Actions of Brain-Derived Neurotrophic Factor Require Vascular Endothelial Growth Factor

(2018) Satoshi Deyama et al.   BIOLOGICAL PSYCHIATRY

The Sex-specific Effects of LPS on Depressive-like Behavior and Oxidative Stress in the Hippocampus of the Mouse

(2018) Caitlin E. Millett et al.   NEUROSCIENCE

Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway

(2017) Satoshi Deyama et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23

(2017) Satoshi Deyama et al.   PSYCHOPHARMACOLOGY

NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice

(2016) Yongjun Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Integrating neuroimmune systems in the neurobiology of depression

(2016) Eric S. Wohleb et al.   NATURE REVIEWS NEUROSCIENCE

Alpha-Tomatine Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated Macrophages

(2015) Ben Zhao et al.   INFLAMMATION

The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)

(2015) Paul E. Greenberg et al.   JOURNAL OF CLINICAL PSYCHIATRY

Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

(2014) Michael C. Dyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effect of steroidal alkaloids on glutamate-induced toxicity by preserving mitochondrial membrane potential and reducing oxidative stress

(2013) Marcos Taveira et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

1,25(OH)2-vitamin D3enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes

(2013) Jérôme Salles et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Alpha-tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo

(2013) Sui-Ting Lee et al.   PHYTOMEDICINE

α-Tomatine-Mediated Anti-Cancer Activity In Vitro and In Vivo through Cell Cycle- and Caspase-Independent Pathways

(2012) Min-Wu Chao et al.   PLoS One

Tomatidine, a Tomato Sapogenol, Ameliorates Hyperlipidemia and Atherosclerosis in ApoE-Deficient Mice by Inhibiting Acyl-CoA:cholesterol Acyl-transferase (ACAT)

(2011) Yukio Fujiwara et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

The Female Urine Sniffing Test: A Novel Approach for Assessing Reward-Seeking Behavior in Rodents

(2009) Oz Malkesman et al.   BIOLOGICAL PSYCHIATRY

Housing conditions and stimulus females: a robust social discrimination task for studying male rodent social recognition

(2009) Abbe H Macbeth et al.   Nature Protocols

Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophages

(2008) Feng-Lan Chiu et al.   FEBS LETTERS

Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial

(2008) R. Jorde et al.   JOURNAL OF INTERNAL MEDICINE

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE