The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops

R-Loops at Chromosome Ends: From Formation, Regulation, and Cellular Consequence

(2023) Yi Gong et al.   Cancers

Walking a tightrope: The complex balancing act of R-loops in genome stability

(2022) Joshua R. Brickner et al.   MOLECULAR CELL

Telomere Interacting Proteins and TERRA Regulation

(2022) Lara Pérez-Martínez et al.   Frontiers in Genetics

Best practices for the visualization, mapping, and manipulation of R‐loops

(2021) Frédéric Chédin et al.   EMBO JOURNAL

TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity

(2021) Yang Mei et al.   Scientific Reports

Telomere Replication: Solving Multiple End Replication Problems

(2021) Erin Bonnell et al.   Frontiers in Cell and Developmental Biology

The makings of TERRA R-loops at chromosome ends

(2021) Rita Valador Fernandes et al.   CELL CYCLE

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

(2021) Jekaterina Vohhodina et al.   Nature Communications

Intrinsically disordered protein RBM14 plays a role in generation of RNA:DNA hybrids at double-strand break sites

(2020) Yumi Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction

(2020) Chongkui Sun et al.   EMBO JOURNAL

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

(2020) Marianna Feretzaki et al.   NATURE

The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability

(2019) Nicole Bettin et al.   Cells

Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

(2019) Jia-Min Zhang et al.   Cell Reports

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

Arginine methylation of the DDX 5 helicase RGG / RG motif by PRMT 5 regulates resolution of RNA:DNA hybrids

(2019) Sofiane Y Mersaoui et al.   EMBO JOURNAL

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

(2019) Bruno Silva et al.   Nature Communications

Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters

(2018) Christopher Grunseich et al.   MOLECULAR CELL

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Human proteins that interact with RNA/DNA hybrids

(2018) Isabel X. Wang et al.   GENOME RESEARCH

Genomic origin and nuclear localization of TERRA telomeric repeat-containing RNA: from Darkness to Dawn

(2017) Aurélie Diman et al.   FEBS Journal

A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA

(2017) Marianna Feretzaki et al.   METHODS

Roles of RNA-Binding Proteins in DNA Damage Response

(2016) Mihoko Kai   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates

(2015) Jaya Sarkar et al.   NUCLEIC ACIDS RESEARCH

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity

(2015) Emilio Cusanelli et al.   Frontiers in Genetics

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin

(2014) Harikleia Episkopou et al.   NUCLEIC ACIDS RESEARCH

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

(2013) Verena Pfeiffer et al.   EMBO JOURNAL

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

(2013) Bingbing Wan et al.   Cell Reports

A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection

(2012) Zhong Deng et al.   EMBO JOURNAL

An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2

(2012) Giulia Biffi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

(2012) Rodrigo Bermejo et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication

(2011) Raghav Chawla et al.   EMBO JOURNAL

The telomeric transcriptome of Schizosaccharomyces pombe

(2011) Amadou Bah et al.   NUCLEIC ACIDS RESEARCH

TERRA biogenesis, turnover and implications for function

(2010) Sascha Feuerhahn et al.   FEBS LETTERS

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Telomeres: protecting chromosomes against genome instability

(2010) Roderick J. O'Sullivan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

siRNA–Mediated Methylation of Arabidopsis Telomeres

(2010) Jan Vrbsky et al.   PLoS Genetics

Purification of Proteins Associated with Specific Genomic Loci

(2009) Jérôme Déjardin et al.   CELL

Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors

(2009) Xiaodong Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

(2009) Laura J. Ng et al.   NUCLEIC ACIDS RESEARCH

CpG-island promoters drive transcription of human telomeres

(2009) S. G. Nergadze et al.   RNA

The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiae

(2008) Brian Luke et al.   MOLECULAR CELL