Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

The Role of Molecular Imaging in Personalized Medicine

(2023) Suliman Salih et al.   Journal of Personalized Medicine

Human Epidermal Growth Factor Receptor 2–Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer

(2023) Ali Alhuseinalkhudhur et al.   JOURNAL OF NUCLEAR MEDICINE

Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule 188Re-ZHER2:41071

(2022) Yongsheng Liu et al.   Pharmaceutics

Preclinical Evaluation of a New Format of 68Ga- and 111In-Labeled Affibody Molecule ZIGF-1R:4551 for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

(2022) Yongsheng Liu et al.   Pharmaceutics

Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

(2022) Maryam Oroujeni et al.   Pharmaceutics

Phase 1 study of intraventricular 131I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies

(2022) Kim Kramer et al.   Journal of Hematology & Oncology

Hopes on immunotherapy targeting B7-H3 in neuroblastoma

(2022) Rafael Pulido et al.   Translational Oncology

Preclinical Evaluation of 99mTc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake

(2021) Maryam Oroujeni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silencing of CD276 suppresses lung cancer progression by regulating integrin signaling

(2020) Fang Li et al.   Journal of Thoracic Disease

B7H3-Directed Intraperitoneal Radioimmunotherapy With Radioiodinated Omburtamab for Desmoplastic Small Round Cell Tumor and Other Peritoneal Tumors: Results of a Phase I Study

(2020) Shakeel Modak et al.   JOURNAL OF CLINICAL ONCOLOGY

Influence of composition of cysteine-containing peptide-based chelators on biodistribution of 99mTc-labeled anti-EGFR affibody molecules

(2018) Maryam Oroujeni et al.   AMINO ACIDS

Same-Day Imaging Using Small Proteins: Clinical Experience and Translational Prospects in Oncology

(2018) Ahmet Krasniqi et al.   JOURNAL OF NUCLEAR MEDICINE

212 Pb-labeled B7-H3-targeting antibody for pancreatic cancer therapy in mouse models

(2018) Benjamin B. Kasten et al.   NUCLEAR MEDICINE AND BIOLOGY

Tumor B7-H3 (CD276) Expression and Survival in Pancreatic Cancer

(2018) Kentaro Inamura et al.   Journal of Clinical Medicine

Molecular imaging of T cell co-regulator factor B7-H3 with 89Zr-DS-5573a

(2018) Ingrid Julienne Georgette Burvenich et al.   Theranostics

Affibody Molecules in Biotechnological and Medical Applications

(2017) Stefan Ståhl et al.   TRENDS IN BIOTECHNOLOGY

Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR:2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator

(2016) Ken G. Andersson et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Comparative Evaluation of Affibody Molecules for Radionuclide Imaging of in Vivo Expression of Carbonic Anhydrase IX

(2016) Javad Garousi et al.   MOLECULAR PHARMACEUTICS

Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: a theragnostic approach

(2016) Aniek J.G. Even et al.   Oncotarget

Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [68Ga]ABY-025 Affibody PET/CT

(2016) Jens Sörensen et al.   Theranostics

In vivo imaging with antibodies and engineered fragments

(2015) Amanda C. Freise et al.   MOLECULAR IMMUNOLOGY

Comparative evaluation of 111In-labeled NOTA-conjugated affibody molecules for visualization of HER3 expression in malignant tumors

(2015) KEN G ANDERSSON et al.   ONCOLOGY REPORTS

Advances in SPECT and PET Hardware

(2015) Piotr J. Slomka et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Affibody-mediated PET imaging of HER3 expression in malignant tumours

(2015) Maria Rosestedt et al.   Scientific Reports

Evaluation of 99mTc-ZIGF1R:4551-GGGC affibody molecule, a new probe for imaging of insulin-like growth factor type 1 receptor expression

(2014) Bogdan Mitran et al.   AMINO ACIDS

Selection of an optimal cysteine-containing peptide-based chelator for labeling of affibody molecules with 188Re

(2014) Mohamed Altai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

First-in-Human Molecular Imaging of HER2 Expression in Breast Cancer Metastases Using the 111In-ABY-025 Affibody Molecule

(2014) J. Sorensen et al.   JOURNAL OF NUCLEAR MEDICINE

Gallium-68-Labeled Affibody Molecule for PET Imaging of PDGFRβ Expression in Vivo

(2014) Joanna Strand et al.   MOLECULAR PHARMACEUTICS

B7-H3 Associated with Tumor Progression and Epigenetic Regulatory Activity in Cutaneous Melanoma

(2013) Jinhua Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

HAHAHA, HEHEHE, HIHIHI, or HKHKHK: Influence of Position and Composition of Histidine Containing Tags on Biodistribution of [99mTc(CO)3]+-Labeled Affibody Molecules

(2013) Camilla Hofström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineered antibodies for molecular imaging of cancer

(2013) Anna M. Wu   METHODS

Correction: Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

(2013) Magdalena Malm et al.   PLoS One

Deciphering complex protein interaction kinetics using Interaction Map

(2012) Danièle Altschuh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

B7-H3 is expressed in human hepatocellular carcinoma and is associated with tumor aggressiveness and postoperative recurrence

(2012) Tai-Wei Sun et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

B7-H3 expression in colorectal cancer: Nuclear localization strongly predicts poor outcome in colon cancer

(2012) Vibeke Anett Ingebrigtsen et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor Targeting Using Affibody Molecules: Interplay of Affinity, Target Expression Level, and Binding Site Composition

(2012) V. Tolmachev et al.   JOURNAL OF NUCLEAR MEDICINE

Order of amino acids in C-terminal cysteine-containing peptide-based chelators influences cellular processing and biodistribution of 99mTc-labeled recombinant Affibody molecules

(2011) Mohamed Altai et al.   AMINO ACIDS

Costimulatory Protein 4IgB7H3 Drives the Malignant Phenotype of Glioblastoma by Mediating Immune Escape and Invasiveness

(2011) D. Lemke et al.   CLINICAL CANCER RESEARCH

Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor β In Vivo

(2011) M. Lindborg et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Design and Optimization of 99mTc-Labeled Recombinant Affibody Molecules Improves Their Biodistribution and Imaging Properties

(2011) H. Wallberg et al.   JOURNAL OF NUCLEAR MEDICINE

B7-H3 Over Expression in Prostate Cancer Promotes Tumor Cell Progression

(2011) Hexing Yuan et al.   JOURNAL OF UROLOGY

HEHEHE-Tagged Affibody Molecule May Be Purified by IMAC, Is Conveniently Labeled with [99mTc(CO)3]+, and Shows Improved Biodistribution with Reduced Hepatic Radioactivity Accumulation

(2010) Vladimir Tolmachev et al.   BIOCONJUGATE CHEMISTRY

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

(2010) Xingxing Zang et al.   MODERN PATHOLOGY

Kit formulation for 99mTc-labeling of recombinant anti-HER2 Affibody molecules with a C-terminally engineered cysteine

(2010) Sara Ahlgren et al.   NUCLEAR MEDICINE AND BIOLOGY

Clinical importance of B7-H3 expression in human pancreatic cancer

(2009) I Yamato et al.   BRITISH JOURNAL OF CANCER

Design, synthesis and biological evaluation of a multifunctional HER2-specific Affibody molecule for molecular imaging

(2009) Thuy A. Tran et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Affibody Molecules for Epidermal Growth Factor Receptor Targeting In Vivo: Aspects of Dimerization and Labeling Chemistry

(2009) V. Tolmachev et al.   JOURNAL OF NUCLEAR MEDICINE

Targeting of HER2-Expressing Tumors with a Site-Specifically 99mTc-Labeled Recombinant Affibody Molecule, ZHER2:2395, with C-Terminally Engineered Cysteine

(2009) S. Ahlgren et al.   JOURNAL OF NUCLEAR MEDICINE

PET versus SPECT: strengths, limitations and challenges

(2009) Arman Rahmim et al.   NUCLEAR MEDICINE COMMUNICATIONS

The Immunoregulatory Protein Human B7H3 is a Tumor-Associated Antigen that Regulates Tumor Cell Migration and Invasion

(2008) Yih-Wen Chen et al.   CURRENT CANCER DRUG TARGETS

Directed Evolution to Low Nanomolar Affinity of a Tumor-Targeting Epidermal Growth Factor Receptor-Binding Affibody Molecule

(2008) Mikaela Friedman et al.   JOURNAL OF MOLECULAR BIOLOGY