Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice

Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease

(2023) Laura Carrero et al.   Acta Neuropathologica Communications

Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions

(2022) Chen Ma et al.   MOLECULES

Sleep–Wake Disorders in Alzheimer’s Disease: A Review

(2022) Yu-Ying Sun et al.   ACS Chemical Neuroscience

The orexin story, sleep and sleep disturbances

(2022) Fabio Pizza et al.   JOURNAL OF SLEEP RESEARCH

Orexin neurons inhibit sleep to promote arousal

(2022) Roberto De Luca et al.   Nature Communications

Selective orexin 1 receptor antagonist SB-334867 aggravated cognitive dysfunction in 3xTg-AD mice

(2022) Wen-Rui Gao et al.   BEHAVIOURAL BRAIN RESEARCH

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Evaluation of SAMP8 Mice as a Model for Sleep-Wake and Rhythm Disturbances Associated with Alzheimer’s Disease: Impact of Treatment with the Dual Orexin (Hypocretin) Receptor Antagonist Lemborexant

(2021) Carsten T. Beuckmann et al.   JOURNAL OF ALZHEIMERS DISEASE

Orexin (hypocretin) mediates light‐dependent fluctuation of hippocampal function in a diurnal rodent

(2021) Joel E. Soler et al.   HIPPOCAMPUS

Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression

(2021) Martin Tolar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sleep timing and the circadian clock in mammals: Past, present and the road ahead

(2021) Raymond E.A. Sanchez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer’s Disease Model

(2021) Eunju Kim et al.   Biomolecules

Mammalian circadian networks mediated by the suprachiasmatic nucleus

(2021) Qingqing Lu et al.   FEBS Journal

Circadian rhythms in neurodegenerative disorders

(2021) Malik Nassan et al.   Nature Reviews Neurology

The role of orexin in Alzheimer disease: From sleep-wake disturbance to therapeutic target

(2021) Fan Gao et al.   NEUROSCIENCE LETTERS

The β-secretase BACE1 in Alzheimer’s disease

(2020) Harald Hampel et al.   BIOLOGICAL PSYCHIATRY

Sleep-Wake Cycle in Alzheimer’s Disease Is Associated with Tau Pathology and Orexin Dysregulation

(2020) Claudio Liguori et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms of Memory Impairment Induced by Orexin-A via Orexin 1 and Orexin 2 Receptors in Post-traumatic Stress Disorder Rats

(2020) Dan Han et al.   NEUROSCIENCE

Phospholipase Cβ3 in the hippocampus may mediate impairment of memory by long-term blockade of orexin 1 receptors assessed by the Morris water maze

(2020) Masoumeh Kourosh-Arami et al.   LIFE SCIENCES

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

(2019) Jerrah K. Holth et al.   SCIENCE

BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease

(2019) Nour M. Moussa‐Pacha et al.   MEDICINAL RESEARCH REVIEWS

The complexity of tau in Alzheimer’s disease

(2019) Nima N. Naseri et al.   NEUROSCIENCE LETTERS

Diurnal Regulation of the Orexin/Hypocretin System in Mice

(2019) Kathrin Ventzke et al.   NEUROSCIENCE

Behavioral and SCN neurophysiological disruption in the Tg-SwDI mouse model of Alzheimer's disease

(2018) Jodi R. Paul et al.   NEUROBIOLOGY OF DISEASE

Abnormal circadian locomotor rhythms and Per gene expression in six-month-old triple transgenic mice model of Alzheimer’s disease

(2018) Meina Wu et al.   NEUROSCIENCE LETTERS

The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model

(2018) Khoa Do et al.   PLoS One

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

(2018) Erik S. Musiek et al.   JAMA Neurology

Temporal and regional progression of Alzheimer’s disease-like pathology in 3xTg-AD mice

(2018) Ramona Belfiore et al.   AGING CELL

Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer’s Disease

(2017) Francesco Bellanti et al.   JOURNAL OF ALZHEIMERS DISEASE

Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer's disease

(2016) Claudio Liguori et al.   NEUROBIOLOGY OF AGING

Orexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer’s disease-risk genes

(2016) Zhixiong Ma et al.   Scientific Reports

Red light at intensities above 10 lx alters sleep–wake behavior in mice

(2016) Ze Zhang et al.   Light-Science & Applications

The Hypothalamus in Alzheimer’s Disease

(2014) Stavros J. Baloyannis et al.   American Journal of Alzheimers Disease and Other Dementias

Acute Suppressive and Long-Term Phase Modulation Actions of Orexin on the Mammalian Circadian Clock

(2014) M. D. C. Belle et al.   JOURNAL OF NEUROSCIENCE

Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors

(2014) Martina Perin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease

(2014) Claudio Liguori et al.   JAMA Neurology

Association between Hypocretin-1 and Amyloid-β42 Cerebrospinal Fluid Levels in Alzheimer’s Disease and Healthy Controls

(2012) Diane Slats et al.   Current Alzheimer Research

JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets

(2010) Michael E. Hughes et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE