β-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes

β-Caryophyllene Attenuates Focal Cerebral Ischemia-Reperfusion Injury by Nrf2/HO-1 Pathway in Rats

(2016) Jie Lou et al.   NEUROCHEMICAL RESEARCH

Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules

(2015) Megumi Ishii et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1–Dependent Withdrawal

(2015) Liting Deng et al.   BIOLOGICAL PSYCHIATRY

AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1

(2014) Hee Yun et al.   FEBS Journal

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury

(2013) In-Young Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain

(2013) A.-L. Klauke et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Physicochemical characterization and pharmacokinetics evaluation of β-caryophyllene/β-cyclodextrin inclusion complex

(2013) Hua Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Saturated fatty acid palmitate-induced insulin resistance is accompanied with myotube loss and the impaired expression of health benefit myokine genes in C2C12 myotubes

(2013) Ming Yang et al.   Lipids in Health and Disease

Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells

(2013) I Dando et al.   Cell Death & Disease

Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-Ay mice

(2012) Mayumi Takada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

(2012) Rai Ajit K. Srivastava et al.   JOURNAL OF LIPID RESEARCH

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy

(2011) D Vara et al.   CELL DEATH AND DIFFERENTIATION

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

(−)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68

(2011) Tomoko Tanaka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

(2011) Alexandre Louvet et al.   HEPATOLOGY

Nuclear receptors in liver disease

(2011) Martin Wagner et al.   HEPATOLOGY

Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice

(2011) Serena Pasquini et al.   JOURNAL OF MEDICINAL CHEMISTRY

AMP-activated protein kinase: nature's energy sensor

(2011) David Carling et al.   Nature Chemical Biology

Functionally selective cannabinoid receptor signalling: Therapeutic implications and opportunities

(2010) Barbara Bosier et al.   BIOCHEMICAL PHARMACOLOGY

Cannabinoid CB2 Receptors in Health and Disease

(2010) K. Patel et al.   CURRENT MEDICINAL CHEMISTRY

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

Palmitate Enhances Protein Tyrosine Phosphatase 1B (PTP1B) Gene Expression at Transcriptional Level in C2C12 Skeletal Muscle Cells

(2010) Narges MohammadTaghvaei et al.   INFLAMMATION

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPKPathways

(2010) Dan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner

(2010) Ji-Min Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress

(2010) Jin-Feng Liu et al.   PHYTOTHERAPY RESEARCH

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY

FoxO1 Controls Insulin-dependent Adipose Triglyceride Lipase (ATGL) Expression and Lipolysis in Adipocytes

(2009) Partha Chakrabarti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms involved in NAFLD progression

(2009) Mariano Malaguarnera et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cannabinoid Type 2 Receptor as a Target for Chronic - Pain

(2009) Massimiliano Beltramo   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Pathogenesis of non-alcoholic fatty liver disease

(2009) J. K. Dowman et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Health-related fitness and physical activity in patients with nonalcoholic fatty liver disease

(2008) Joanne B. Krasnoff et al.   HEPATOLOGY

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management

(2008) Raj Vuppalanchi et al.   HEPATOLOGY

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of fatty acids in the development and progression of nonalcoholic fatty liver disease

(2008) Christopher L. Gentile et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Alterations in Fatty Acid Kinetics in Obese Adolescents With Increased Intrahepatic Triglyceride Content

(2008) Elisa Fabbrini et al.   Obesity

Beta-caryophyllene is a dietary cannabinoid

(2008) Jürg Gertsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CB2 receptors as new therapeutic targets for liver diseases

(2007) S Lotersztajn et al.   BRITISH JOURNAL OF PHARMACOLOGY