Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

(2022) Dominic D. G. Owens et al.   Nature Communications

Humanized Mouse Models to Evaluate Cancer Immunotherapeutics

(2021) Silvia Guil-Luna et al.   Annual Review of Cancer Biology-Series

Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia

(2021) Xiuqin Bao et al.   AMERICAN JOURNAL OF HUMAN GENETICS

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(2021) Harvey George Roweth et al.   BLOOD

Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer

(2020) Lukas Lanser et al.   Frontiers in Immunology

Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy

(2020) Weimin Wang et al.   MOLECULAR CELL

Transcription Factor Stoichiometry Drives Cell Fate: Single-Cell Proteomics to the Rescue

(2019) Thomas Graf   Cell Stem Cell

Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Humans and Mice

(2019) Juliana Xavier-Ferrucio et al.   BLOOD

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

(2019) Niranjan Venkateswaran et al.   GENES & DEVELOPMENT

Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents

(2018) Xiaohong Ruby Xu et al.   BLOOD

Tumor-Repopulating Cells Induce PD-1 Expression in CD8 + T Cells by Transferring Kynurenine and AhR Activation

(2018) Yuying Liu et al.   CANCER CELL

The Platelet Lifeline to Cancer: Challenges and Opportunities

(2018) Monika Haemmerle et al.   CANCER CELL

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells

(2018) Yuying Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

(2018) Brian W. Labadie et al.   CLINICAL CANCER RESEARCH

The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment

(2018) Rahul Shinde et al.   TRENDS IN IMMUNOLOGY

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

(2017) Yuying Liu et al.   Nature Communications

Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38midfraction

(2016) Chad Sanada et al.   BLOOD

Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells

(2016) Stefan Rentas et al.   NATURE

Concise Review: Stem Cell Population Biology: Insights from Hematopoiesis

(2016) Adam L. MacLean et al.   STEM CELLS

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

(2016) Thomas Moreau et al.   Nature Communications

PF4 Promotes Platelet Production and Lung Cancer Growth

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Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice

(2016) Susann Rahmig et al.   Stem Cell Reports

RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation

(2015) O. N. Kuvardina et al.   BLOOD

The RUNX1 +24 Enhancer and P1 Promoter Identify a Unique Subpopulation of Hematopoietic Progenitor Cells Derived from Human Pluripotent Stem Cells

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Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis

(2014) Maxim Pimkin et al.   GENOME RESEARCH

JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia

(2013) C. M. Hobbs et al.   BLOOD

Full reconstitution of human platelets in humanized mice after macrophage depletion

(2012) Z. Hu et al.   BLOOD

Histone arginine methylation keeps RUNX1 target genes in an intermediate state

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The Evolving Role of the Aryl Hydrocarbon Receptor (AHR) in the Normophysiology of Hematopoiesis

(2012) Stephan Lindsey et al.   Stem Cell Reviews and Reports

The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization

(2011) Stephan Lindsey et al.   BRITISH JOURNAL OF HAEMATOLOGY

Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators

(2011) Marloes R. Tijssen et al.   DEVELOPMENTAL CELL

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(2011) B. PSAILA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

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(2010) M. Dicato et al.   ANNALS OF ONCOLOGY

c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression

(2010) E. Bianchi et al.   BLOOD

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

(2010) Anthony E. Boitano et al.   SCIENCE