The RUNX1 +24 Enhancer and P1 Promoter Identify a Unique Subpopulation of Hematopoietic Progenitor Cells Derived from Human Pluripotent Stem Cells

RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells

(2013) D. Ran et al.   BLOOD

The Wnt- -catenin pathway represses let-7 microRNA expression through transactivation of Lin28 to augment breast cancer stem cell expansion

(2013) W.-Y. Cai et al.   JOURNAL OF CELL SCIENCE

CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia

(2013) Ye Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of Engraftable Hematopoietic Stem Cells From Induced Pluripotent Stem Cells by Way of Teratoma Formation

(2013) Nao Suzuki et al.   MOLECULAR THERAPY

Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy

(2013) David A. Knorr et al.   Stem Cells Translational Medicine

Efficient generation, purification, and expansion of CD34+ hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells

(2012) J. L. Gori et al.   BLOOD

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

(2012) H. Guo et al.   BLOOD

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells

(2012) G. Amabile et al.   BLOOD

Efficient and simultaneous generation of hematopoietic and vascular progenitors from human induced pluripotent stem cells

(2012) Tea Soon Park et al.   CYTOMETRY PART A

Expression analysis of mir-17-5p, mir-20a and let-7a microRNAs and their target proteins in CD34+ bone marrow cells of patients with myelodysplastic syndromes

(2012) Diamantina Vasilatou et al.   LEUKEMIA RESEARCH

Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs

(2012) Jingmin Shu et al.   RNA Biology

Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc

(2011) Yongchao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expansion of functionally defined mouse hematopoietic stem and progenitor cells by a short isoform of RUNX1/AML1

(2011) S. Tsuzuki et al.   BLOOD

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

(2011) F. Notta et al.   SCIENCE

Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells

(2011) Lloyd A. Pereira et al.   Stem Cell Research

Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis

(2010) T. Bee et al.   BLOOD

Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells

(2010) E. Y. N. Lam et al.   BLOOD

Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells

(2010) Grant A. Challen et al.   EXPERIMENTAL HEMATOLOGY

Cell-Type-Specific Activation and Repression of PU.1 by a Complex of Discrete, Functionally Specialized cis-Regulatory Elements

(2010) M. A. Zarnegar et al.   MOLECULAR AND CELLULAR BIOLOGY

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

A Runx1 Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells

(2010) Cherry Ee Lin Ng et al.   STEM CELLS

The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis

(2009) P. Sroczynska et al.   BLOOD

Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells

(2009) D. S. Kaufman   BLOOD

A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis

(2009) O. Klimchenko et al.   BLOOD

Alternative Runx1 promoter usage in mouse developmental hematopoiesis

(2009) Thomas Bee et al.   BLOOD CELLS MOLECULES AND DISEASES

Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation

(2009) Christopher R. Dowdy et al.   HUMAN MOLECULAR GENETICS

Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell–derived lin–CD34+CD43+CD45+ progenitors

(2009) Kyung-Dal Choi et al.   JOURNAL OF CLINICAL INVESTIGATION

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

ErythRED, a hESC line enabling identification of erythroid cells

(2009) Tanya Hatzistavrou et al.   NATURE METHODS

Wnt, Activin, and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood

(2008) M. Cristina Nostro et al.   Cell Stem Cell

Efficient Hematopoietic Differentiation of Human Embryonic Stem Cells on Stromal Cells Derived from Hematopoietic Niches

(2008) Maria H. Ledran et al.   Cell Stem Cell

The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF

(2008) S. Pearson et al.   DEVELOPMENT

A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies

(2008) Elizabeth S Ng et al.   Nature Protocols

Hematopoiesis and immunity of HOXB4-transduced embryonic stem cell-derived hematopoietic progenitor cells

(2007) K.-M. Chan et al.   BLOOD