Higher Vulnerability of Menadione-Exposed Cortical Astrocytes of Glutaryl-CoA Dehydrogenase Deficient Mice to Oxidative Stress, Mitochondrial Dysfunction, and Cell Death: Implications for the Neurodegeneration in Glutaric Aciduria Type I

Experimental evidence that bioenergetics disruption is not mainly involved in the brain injury of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload

(2015) Alexandre Umpierrez Amaral et al.   BRAIN RESEARCH

A role of astrocytes in mediating postnatal neurodegeneration in Glutaric acidemia-type 1

(2015) Silvia Olivera-Bravo et al.   FEBS LETTERS

Striatal neuronal death mediated by astrocytes from the Gcdh−/− mouse model of glutaric acidemia type I

(2015) Silvia Olivera-Bravo et al.   HUMAN MOLECULAR GENETICS

Experimental evidence that overexpression of NR2B glutamate receptor subunit is associated with brain vacuolation in adult glutaryl-CoA dehydrogenase deficient mice: A potential role for glutamatergic-induced excitotoxicity in GA I neuropathology

(2015) Marília Danyelle Nunes Rodrigues et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Disturbance of the glutamatergic system by glutaric acid in striatum and cerebral cortex of glutaryl-CoA dehydrogenase-deficient knockout mice: Possible implications for the neuropathology of glutaric acidemia type I

(2014) Estela Natacha Brandt Busanello et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Acute lysine overload provokes protein oxidative damage and reduction of antioxidant defenses in the brain of infant glutaryl-CoA dehydrogenase deficient mice: A role for oxidative stress in GA I neuropathology

(2014) Bianca Seminotti et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Increased Glutamate Receptor and Transporter Expression in the Cerebral Cortex and Striatum of Gcdh-/- Mice: Possible Implications for the Neuropathology of Glutaric Acidemia Type I

(2014) Valeska Lizzi Lagranha et al.   PLoS One

White Matter Injury Induced by Perinatal Exposure to Glutaric Acid

(2013) Silvia Olivera-Bravo et al.   NEUROTOXICITY RESEARCH

Characterization of Adult Rat Astrocyte Cultures

(2013) Débora Guerini Souza et al.   PLoS One

Ammonium Accumulation and Cell Death in a Rat 3D Brain Cell Model of Glutaric Aciduria Type I

(2013) Paris Jafari et al.   PLoS One

Resveratrol Protects C6 Astrocyte Cell Line against Hydrogen Peroxide-Induced Oxidative Stress through Heme Oxygenase 1

(2013) André Quincozes-Santos et al.   PLoS One

Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe

(2012) Yangping Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of oxidative stress in brain of glutaryl-CoA dehydrogenase deficient mice by acute lysine administration

(2012) Bianca Seminotti et al.   MOLECULAR GENETICS AND METABOLISM

Reduction of Na+, K+-ATPase activity and expression in cerebral cortex of glutaryl-CoA dehydrogenase deficient mice: A possible mechanism for brain injury in glutaric aciduria type I

(2012) Alexandre Umpierrez Amaral et al.   MOLECULAR GENETICS AND METABOLISM

Marked reduction of Na+, K+-ATPase and creatine kinase activities induced by acute lysine administration in glutaryl-CoA dehydrogenase deficient mice

(2012) Alexandre Umpierrez Amaral et al.   MOLECULAR GENETICS AND METABOLISM

Disruption of brain redox homeostasis in glutaryl-CoA dehydrogenase deficient mice treated with high dietary lysine supplementation

(2012) Bianca Seminotti et al.   MOLECULAR GENETICS AND METABOLISM

Resveratrol Prevents Ammonia Toxicity in Astroglial Cells

(2012) Larissa Daniele Bobermin et al.   PLoS One

Glutaric Aciduria Type 1 Metabolites Impair the Succinate Transport from Astrocytic to Neuronal Cells

(2011) Jessica Lamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neonatal Astrocyte Damage Is Sufficient to Trigger Progressive Striatal Degeneration in a Rat Model of Glutaric Acidemia-I

(2011) Silvia Olivera-Bravo et al.   PLoS One

Vulnerability to Oxidative Stress In Vitro in Pathophysiology of Mitochondrial Short-Chain Acyl-CoA Dehydrogenase Deficiency: Response to Antioxidants

(2011) Zarazuela Zolkipli et al.   PLoS One

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis

(2010) Gabriel Loor et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant dysfunction: potential risk for neurotoxicity in ethylmalonic aciduria

(2010) Christina B. Pedersen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Studies on Plasmalogen-Selective Phospholipase A2 in Brain

(2010) Akhlaq A. Farooqui   MOLECULAR NEUROBIOLOGY

Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?

(2010) K.L. Double et al.   PROGRESS IN NEUROBIOLOGY

Functional Aspects of Redox Control During Neuroinflammation

(2009) Sergio Rosales-Corral et al.   ANTIOXIDANTS & REDOX SIGNALING

The Janus Face of Resveratrol in Astroglial Cells

(2009) André Quincozes-Santos et al.   NEUROTOXICITY RESEARCH

Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment

(2008) Paloma Bermejo et al.   FREE RADICAL RESEARCH

Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: Possible implications for GAI pathogenesis

(2008) Silvia Olivera et al.   NEUROBIOLOGY OF DISEASE