Association of C677T and A1298C polymorphisms of the MTHFR gene with maternal risk for Down syndrome: A meta-analysis of case-control studies

Maternal MTHFR 677C>T, 1298A>C gene polymorphisms and risk of offspring aneuploidy

(2022) Olivera Miljanović et al.   PRENATAL DIAGNOSIS

Folic acid fortification of flour to prevent neural tube defects in Europe – A position statement by the European Board and college of obstetrics and gynaecology (EBCOG)

(2022) Sarah Petch et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Fission Yeast Methylenetetrahydrofolate Reductase Ensures Mitotic and Meiotic Chromosome Segregation Fidelity

(2021) Kim Kiat Lim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

One-carbon metabolism and global DNA methylation in mothers of individuals with Down syndrome

(2021) Cristiani Cortez Mendes et al.   Human Cell

Polymorphisms of the MTHFR gene in mothers of children with trisomy 21 (Down syndrome) in a Polish population

(2020) Paulina Czechowicz et al.   Advances in Clinical and Experimental Medicine

Mechanisms of oocyte aneuploidy associated with advanced maternal age

(2020) Myy Mikwar et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Genetic polymorphisms in folate metabolism as risk for Down syndrome in the southern China

(2018) Lin Jiajin et al.   Journal of Maternal-Fetal & Neonatal Medicine

The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes

(2018) Yuan Zhang et al.   PRENATAL DIAGNOSIS

Adult Nutrient Intakes from Current National Dietary Surveys of European Populations

(2017) Holly Rippin et al.   Nutrients

Genetic polymorphisms and folate status

(2017) Mami Hiraoka et al.   CONGENITAL ANOMALIES

Risk factors for Down syndrome

(2016) Fabio Coppedè   ARCHIVES OF TOXICOLOGY

Synthetic combinations of missense polymorphic genetic changes underlying Down syndrome susceptibility

(2016) Rebecca A. Jackson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Application of the Key Events Dose-response Framework to Folate Metabolism

(2015) Jing Hu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Folate Metabolism Gene Polymorphisms and Risk for Down Syndrome Offspring in Turkish Women

(2015) Ozlem Izci Ay et al.   Genetic Testing and Molecular Biomarkers

Role of folate-homocysteine pathway gene polymorphisms and nutritional cofactors in Down syndrome: A triad study

(2015) K.K. Sukla et al.   HUMAN REPRODUCTION

The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects

(2015) Fabio Coppedè   Frontiers in Genetics

Meta-analysis of Methylenetetrahydrofolate reductase maternal gene in Down syndrome: increased susceptibility in women carriers of the MTHFR 677T allele

(2014) D. B. Victorino et al.   MOLECULAR BIOLOGY REPORTS

Maternal Methylenetetrahydrofolate Reductase C677T Polymorphism and Down Syndrome Risk: A Meta-Analysis from 34 Studies

(2014) Vandana Rai et al.   PLoS One

MTHFR Genetic Polymorphism As a Risk Factor in Egyptian Mothers with Down Syndrome Children

(2013) Nagwa A. Meguid et al.   DISEASE MARKERS

The impact of Folate Pathway Polymorphisms Combined to Nutritional Deficiency As a Maternal Predisposition Factor for Down Syndrome

(2013) C. B. Santos-Rebouças et al.   DISEASE MARKERS

Functional Inference of Methylenetetrahydrofolate Reductase Gene Polymorphisms on Enzyme Stability as a Potential Risk Factor for Down Syndrome in Croatia

(2013) Jadranka Vraneković et al.   DISEASE MARKERS

Maternal Risk for Down Syndrome Is Modulated by Genes Involved in Folate Metabolism

(2013) Bruna Lancia Zampieri et al.   DISEASE MARKERS

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring: a meta-analysis

(2013) Xiaoming Wu et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Association of maternal and fetal MTHFR A1298C polymorphism with the risk of pregnancy loss: a study of an Indian population and a meta-analysis

(2013) Rohini R. Nair et al.   FERTILITY AND STERILITY

Folate: Metabolism, genes, polymorphisms and the associated diseases

(2013) Fakhira Hassan Nazki et al.   GENE

Maternal gene polymorphisms involved in folate metabolism and the risk of having a Down syndrome offspring: a meta-analysis

(2013) M. Yang et al.   MUTAGENESIS

Association of methylenetetrahydrofolate reductase gene 677C > T polymorphism and Down syndrome

(2012) Marcelo Aguiar Costa-Lima et al.   MOLECULAR BIOLOGY REPORTS

Molecular basis of maternal age-related increase in oocyte aneuploidy

(2011) Hiroki Kurahashi et al.   CONGENITAL ANOMALIES

Methylenetetrahydrofolate Reductase Polymorphisms C677T and A1298C as Maternal Risk Factors for Down Syndrome in Jordan

(2011) May F. Sadiq et al.   Genetic Testing and Molecular Biomarkers

Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome

(2010) Adam E. Locke et al.   GENETIC EPIDEMIOLOGY

Chromosome 21 non-disjunction and Down syndrome birth in an Indian cohort: analysis of incidence and aetiology from family linkage data

(2010) SUJOY GHOSH et al.   Genetics Research

MTHFR C677T and A1298C polymorphisms as a risk factor for congenital heart defects in Down syndrome

(2010) Ivana Babić Božović et al.   PEDIATRICS INTERNATIONAL

Evaluation of C677T and A1298C polymorphisms of theMTHFRgene as maternal risk factors for Down syndrome and congenital heart defects

(2009) Ana Paula Carneiro Brandalize et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Maternal polymorphisms for methyltetrahydrofolate reductase and methionine synthetase reductase and risk of children with Down syndrome

(2009) Elisa Pozzi et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The complex relationship between folate/homocysteine metabolism and risk of Down syndrome

(2009) Fabio Coppedè   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The biochemical structure and function of methylenetetrahydrofolate reductase provide the rationale to interpret the epidemiological results on the risk for infants with Down syndrome

(2008) M.L. Martínez-Frías   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China

(2008) Shao-shuai Wang et al.   Journal of Zhejiang University-SCIENCE B

Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring

(2008) Fabio Coppedè et al.   NEUROSCIENCE LETTERS