B cell mediated CD4 T cell co-stimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation

Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

(2022) Mathieu Uzzan et al.   NATURE MEDICINE

Critical role of WASp in germinal center tolerance through regulation of B cell apoptosis and diversification

(2022) Marc Descatoire et al.   Cell Reports

B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing

(2022) Annika Frede et al.   IMMUNITY

Cutting Edge: A Threshold of B Cell Costimulatory Signals Is Required for Spontaneous Germinal Center Formation in Autoimmunity

(2021) Kristy Chiang et al.   JOURNAL OF IMMUNOLOGY

Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans

(2020) Connie W.Y. Ha et al.   CELL

Microbial network disturbances in relapsing refractory Crohn’s disease

(2019) Bahtiyar Yilmaz et al.   NATURE MEDICINE

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

(2019) Maik Luu et al.   Nature Communications

De Novo Colitis Associated With Rituximab in 21 Patients at a Tertiary Center

(2019) Jason D. Eckmann et al.   Clinical Gastroenterology and Hepatology

Abatacept modulates CD80 and CD86 expression and memory formation in human B-cells

(2019) Raquel Lorenzetti et al.   JOURNAL OF AUTOIMMUNITY

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

(2019) Christopher S. Smillie et al.   CELL

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

(2019) Evan Bolyen et al.   NATURE BIOTECHNOLOGY

Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification

(2019) Paulo Czarnewski et al.   Nature Communications

Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

(2019) Jerome C. Martin et al.   CELL

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease

(2018) Pedro Gonçalves et al.   INFLAMMATORY BOWEL DISEASES

Autonomous role of Wiskott-Aldrich syndrome platelet deficiency in inducing autoimmunity and inflammation

(2018) Lucia Sereni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4+T Cell Polarization

(2018) Seung-Chul Choi et al.   JOURNAL OF IMMUNOLOGY

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

(2018) Amlan Biswas et al.   Nature Communications

Shaping the humoral immune response: Actin regulators modulate antigen presentation and influence B-T interactions

(2018) Marianne Burbage et al.   MOLECULAR IMMUNOLOGY

B cell–derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity

(2017) Tanvi Arkatkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory bowel disease caused by primary immunodeficiencies-Clinical presentations, review of literature, and proposal of a rational diagnostic algorithm

(2017) Daniel Tegtmeyer et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6

(2016) Shaun W. Jackson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome

(2015) Nikita S. Kolhatkar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells

(2015) Selina Jessica Keppler et al.   IMMUNITY

Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies

(2015) Carin I.M. Dahlberg et al.   JOURNAL OF AUTOIMMUNITY

The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct

(2015) S A Houston et al.   Mucosal Immunology

Interleukin (IL)-21 promotes intestinal IgA response to microbiota

(2015) A T Cao et al.   Mucosal Immunology

B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice

(2012) M. Recher et al.   BLOOD

Abatacept for Crohn's Disease and Ulcerative Colitis

(2012) William J. Sandborn et al.   GASTROENTEROLOGY

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis

(2011) K. Leiper et al.   GUT

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity

(2011) Shirly Becker-Herman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ulcerative Colitis

(2011) Silvio Danese et al.   NEW ENGLAND JOURNAL OF MEDICINE

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY