Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

(2023) Anabel Zelceski et al.   Cell Reports

Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells

(2022) Laura Sanchez‐Burgos et al.   EMBO Molecular Medicine

SimPLIT: Simplified Sample Preparation for Large-Scale Isobaric Tagging Proteomics

(2022) Fernando J. Sialana et al.   JOURNAL OF PROTEOME RESEARCH

Recent insight into the role of FBXW7 as a tumor suppressor

(2020) Kanae Yumimoto et al.   SEMINARS IN CANCER BIOLOGY

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib

(2020) Wayne D. Blosser et al.   Oncotarget

ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition

(2020) Michael D. Rainey et al.   Cell Reports

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

(2019) Tatiana N. Moiseeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes

(2018) Sara Rodriguez-Acebes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1

(2017) Robert C. Alver et al.   Cell Reports

p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress

(2016) Slavica Tudzarova et al.   CELL CYCLE

miR-363 promotes proliferation and chemo-resistance of human gastric cancer via targeting of FBW7 ubiquitin ligase expression

(2016) Peng-Fei Zhang et al.   Oncotarget

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

(2016) Konstantinos Tzelepis et al.   Cell Reports

Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture

(2016) Federica Lorenzi et al.   Molecular Therapy-Methods & Clinical Development

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase

(2015) Irina Bruck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15

(2015) Ningning Li et al.   Oncotarget

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression

(2014) Y.-J. Sheu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

(2013) Nathan W. Pierce et al.   CELL

Mechanisms and function of substrate recruitment by F-box proteins

(2013) Jeffrey R. Skaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Discovery of XL413, a potent and selective CDC7 inhibitor

(2012) Elena S. Koltun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells

(2010) Mei-Chuan Chen et al.   HEPATOLOGY