Article
Anatomy & Morphology
Reham Ismail Taha, Mansour Abdullah Alghamdi, Alshehri Hanan Hassan, Eman Ali Al Qahtani, Khulood Mohammed Al-Khater, Rashid A. Aldahhan, Eman Mohamad El Nashar
Summary: This study investigated the effects of intermittent fasting on aquaporins, oxidative stress, and autophagy in the salivary glands of diabetic rats. The results showed that intermittent fasting decreased oxidative stress, increased aquaporin 1 expression, improved salivary secretion, and reduced autophagy in the submandibular and parotid glands.
Article
Clinical Neurology
Emma M. J. Passchier, Sven Kerst, Eelke Brouwers, Eline M. C. Hamilton, Quinty Bisseling, Marianna Bugiani, Quinten Waisfisz, Philip Kitchen, Lucas Unger, Marjolein Breur, Leoni Hoogterp, Sharon de Vries, Truus E. M. Abbink, Maarten H. P. Kole, Rob Leurs, Henry F. Vischer, Maria S. Brignone, Elena Ambrosini, Francois Feillet, Alfred P. Born, Leon G. Epstein, Huibert D. Mansvelder, Rogier Min, Marjo S. van der Knaap
Summary: Brain oedema is a life-threatening complication of various neurological conditions. Understanding molecular mechanisms of brain volume regulation is critical for therapy development. We performed genetic studies to identify novel gene variants in MLC patients, diagnosed by clinical and MRI features, without MLC1 or GLIALCAM variants. We identified aquaporin-4 and GPRC5B as old and new players in genetic brain oedema, shedding light on the protein complex involved in astrocyte volume regulation and identifying GPRC5B as a novel potentially druggable target for treating brain oedema.
Article
Veterinary Sciences
Patricia Alvarez, Ester Blasco, Marti Pumarola, Annette Wessmann
Summary: This study confirmed the expression of AQP4 in normal canine brains, with a predilection for white matter tracts. Younger dogs showed more diffuse AQP4 labeling in both gray and white matter tracts, suggesting a potential influence of brain development and aging on AQP4 distribution. Further larger studies are needed to explore the impact of breed and aging on AQP4 expression in the normal canine brain.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Qi Lu, Jun Xiong, Yuan Yuan, Zhanwei Ruan, Yu Zhang, Bo Chai, Lei Li, Shufang Cai, Jian Xiao, Yanqing Wu, Peng Huang, Hongyu Zhang
Summary: This study demonstrates that minocycline can improve the functional recovery of traumatic brain injury (TBI) by reducing the levels of aquaporin-4 (AQP4). Minocycline treatment effectively reduces neuronal apoptosis, ameliorates brain edema and blood-brain barrier disruption in TBI. The expression of tight junction proteins and the morphology of astrocytes are also optimized by minocycline administration. AQP4 may be an important therapeutic target for minocycline treatment of TBI.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ronja Bihlmaier, Felix Deffner, Ulrich Mattheus, Peter H. Neckel, Bernhard Hirt, Andreas F. Mack
Summary: The choroid plexus is responsible for producing cerebrospinal fluid in the brain ventricles and serves as a blood-CSF barrier. Immunofluorescence and electron microscopy showed that ependymal cells and subependymal astrocytes in the choroid plexus expressed aquaporin-4, which may facilitate water transport. The glial plate surrounding the choroid plexus also demonstrated high AQP4 density, suggesting a possible drainage and clearing pathway for metabolites.
Article
Biochemistry & Molecular Biology
Wuyang Lv, Lei Liang, Dongyang Liu, Cuicui Li, Liao Jia, Yingyu Jin
Summary: This study investigated the role of AQP1 in ferroptosis, macrophage polarization, mitochondrial dysfunction, and impaired autophagy of LPS-stimulated RAW264.7 cells. The results showed that AQP1 promotes ferroptosis, M1 polarization, mitochondrial dysfunction, and autophagy impairment by inhibiting the expression of P53 in LPS-stimulated RAW264.7 cells. AQP1 or P53 may be considered as crucial determiners that regulate the biological behavior of RAW264.7 cells stimulated by LPS.
DNA AND CELL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuang Zou, Yu-Long Lan, Tong Ren, Xiangyu Li, Lijun Zhang, Hongjin Wang, Xun Wang
Summary: The study identified high expression of AQP4 in CNS tumors, which was closely related to patient prognosis and influenced lymphocyte and cancer-associated fibroblast infiltration. Furthermore, AQP4 functional mechanisms were found to be associated with synaptic vesicle cycle and phosphatidylinositol signaling system.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biology
Ehsan Dadgostar, Vida Tajiknia, Negar Shamsaki, Mojtaba Naderi-Taheri, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji
Summary: Brain-related disorders are significant global health issues, with factors such as inflammatory pathways and deregulations of various channels playing key roles in their progression. Aquaporins (AQP), specifically AQP4, have critical impacts on controlling apoptosis pathways in these disorders.
Article
Plant Sciences
Jie Tang, Diane C. Bassham
Summary: Drought poses a major challenge for agricultural production, but autophagy plays a crucial role in helping plants survive drought stress by regulating water permeability, degrading toxic proteins, and promoting stress responses. The activation of autophagy through transcriptional and post-translational mechanisms may offer promising strategies for enhancing drought tolerance in plants.
Article
Cell & Tissue Engineering
J. W. Snuggs, R. A. D. Bunning, C. L. Le Maitre
Summary: The study shows that transient receptor potential vanilloid 4 is expressed in human nucleus pulposus cells and plays an important role in their response to osmotic gradients. Aquaporin 1, 4, and transient receptor potential vanilloid 4 are involved in the fundamental adaptation of nucleus pulposus cells to their osmotic environment, with co-localization with primary cilia suggesting synergistic function that may be lost during disc degeneration.
EUROPEAN CELLS & MATERIALS
(2021)
Article
Multidisciplinary Sciences
Yalan Zhang, Luis Varela, Klara Szigeti-Buck, Adam Williams, Milan Stoiljkovic, Matija Sestan-Pesa, Jorge Henao-Mejia, Pasquale D'Acunzo, Efrat Levy, Richard A. Flavell, Tamas L. Horvath, Leonard K. Kaczmarek
Summary: The interaction between Kv3.3 channel and TBK1 enzyme plays a crucial role in modulating the survival and death of cerebellar neurons, with Hax-1 being a key player in this regulatory process.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Ehsan Dadgostar, Shiva Rahimi, Shahin Nikmanzar, Sina Nazemi, Mojtaba Naderi Taheri, Zahra Alibolandi, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji
Summary: This review summarizes the current knowledge and evidence on the relationship between AQP4 and TBI, as well as the potential mechanisms involved.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hyo Jin Choi, Mun Han, Byeongjin Jung, Yu-Ri Hong, Seulgi Shin, Sungsu Lim, Eun-Hee Lee, Yun Kyung Kim, Juyoung Park
Summary: This study demonstrates the potential of MRgFUS as a delivery system to enhance the efficacy of therapeutic drugs for Alzheimer's disease. The use of MRgFUS significantly improved the brain accumulation of methylene blue and reduced the deposition of amyloid-beta plaques.
Article
Biochemistry & Molecular Biology
Xiaosong Liu, Yingxin Xie, Xiangdong Wan, Jianliang Wu, Zhenzeng Fan, Lijun Yang
Summary: The study demonstrates that AQP4 deficiency can alleviate brain edema and neurological deficits in TBI patients, improve cognitive outcomes, and enhance longer-term neurological results.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Manuela de Bellis, Antonio Cibelli, Maria Grazia Mola, Francesco Pisani, Barbara Barile, Maria Mastrodonato, Shervin Banitalebi, Mahmood Amiry-Mogghaddam, Pasqua Abbrescia, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchia
Summary: This study demonstrates the crucial role of AQP4 assemblies in maintaining normal AQP4 expression levels in the brain, with most AQP4 organized into OAPs under physiological conditions. Astrocytes cannot use AQP4 tetramers as an alternative to OAPs without affecting AQP4 expression levels.
Article
Microbiology
April S. Gislason, Matthew Choy, Ruhi A. M. Bloodworth, Wubin Qu, Maria S. Stietz, Xuan Li, Chenggang Zhang, Silvia T. Cardona
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Article
Biochemistry & Molecular Biology
Yiming Lu, Cheng Quan, Hebing Chen, Xiaochen Bo, Chenggang Zhang
NUCLEIC ACIDS RESEARCH
(2017)
Article
Multidisciplinary Sciences
Jibin Sha, Chenggang Zhang
Article
Medicine, General & Internal
Jiguo Xue, Cheng Quan, Chunyong Li, Jingwei Yue, Chenggang Zhang
Article
Oncology
Xiaohui Zhu, Yangdong Sun, Chenggang Zhang, Haifeng Liu
MOLECULAR MEDICINE REPORTS
(2017)
Article
Oncology
Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhang
MOLECULAR MEDICINE REPORTS
(2017)
Article
Multidisciplinary Sciences
Chunyong Li, Jiguo Xue, Cheng Quan, Jingwei Yue, Chenggang Zhang
Article
Oncology
Zenghua Deng, Zhihui Li, Changqing Sun, Hui Xie, Zhengang Chen, Jinbo Liu, Hui Wang, Chenggang Zhang, Guangshun Wang
Article
Multidisciplinary Sciences
Cheng Quan, Chunyong Li, Jiguo Xue, Jingwei Yue, Chenggang Zhang
Article
Multidisciplinary Sciences
Jiguo Xue, Chunyong Li, Cheng Quan, Yiming Lu, Jingwei Yue, Chenggang Zhang
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Kun Wang, Haiwei Li, Yue Xu, Qianzhi Shao, Jianming Yi, Ruichao Wang, Wanshi Cai, Xingyi Hang, Chenggang Zhang, Haoyang Cai, Wubin Qu
NUCLEIC ACIDS RESEARCH
(2019)
Article
Genetics & Heredity
Hao Lu, Luyu Ma, Cheng Quan, Lei Li, Yiming Lu, Gangqiao Zhou, Chenggang Zhang
Summary: This study introduces a computational framework called RegVar, based on deep neural networks, which accurately predicts the tissue-specific impact of non-coding regulatory variants on target genes. RegVar outperforms current methods in predicting regulatory variants and is capable of assessing the regulatory impact of any variant on its putative target genes in various tissues.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Article
Food Science & Technology
Chenggang Zhang, Wenjing Gong, Zhihui Li, Dawen Gao, Yan Gao
FOOD SCIENCE AND HUMAN WELLNESS
(2019)
Article
Medicine, Research & Experimental
Ji-Bin Sha, Shuang-Shuang Zhang, Yi-Ming Lu, Wen-Jing Gong, Xiao-Ping Jiang, Jian-Jun Wang, Tong-Ling Qiao, Hong-Hong Zhang, Min-Qian Zhao, Da-Peng Wang, Hua Xia, Zhong-Wei Li, Jian-Liang Chen, Lin Zhang, Cheng-Gang Zhang
MEDICAL GAS RESEARCH
(2018)
Article
Oncology
Yu Wang, Wei Chen, Bin Hou, Yan Gao, Zhihui Li, Xu Li, Chenggang Zhang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2018)