The Role of the WGR Domain in the Functions of PARP1 and PARP2

PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites

(2022) Xiaohui Lin et al.   NUCLEIC ACIDS RESEARCH

Inhibitors of PARP: Number crunching and structure gazing

(2022) Johannes Rudolph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro

(2022) Elena Y. Kotova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling

(2021) Lotte van Beek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice

(2021) Miguel A Galindo-Campos et al.   BLOOD

miR-149-PARP-2 Signaling Regulates E-cadherin and N-cadherin Expression in the Murine Model of Endometrium Receptivity

(2021) Raj Kumar Verma et al.   Reproductive Sciences

Mechanisms of Nucleosome Reorganization by PARP1

(2021) Natalya V. Maluchenko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer

(2021) Johannes Rudolph et al.   MOLECULAR CELL

PARPs and ADP-ribosylation: 60 years on

(2020) W. Lee Kraus   GENES & DEVELOPMENT

Nuclear PARPs and genome integrity

(2020) Kameron Azarm et al.   GENES & DEVELOPMENT

Silencing of PARP2 Blocks Autophagic Degradation

(2020) Laura Jankó et al.   Cells

Probing the Conformational Changes Associated with DNA Binding to PARP1

(2020) Johannes Rudolph et al.   BIOCHEMISTRY

Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8

(2020) Upendra Kumar Soni et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

(2020) Silvija Bilokapic et al.   NATURE

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

(2020) Zhengping Shao et al.   NUCLEIC ACIDS RESEARCH

Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes

(2019) Colin Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA

(2019) Anastasia S. Singatulina et al.   Cell Reports

Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity

(2019) Travis Eisemann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanistic insight into the role of Poly(ADP-ribosyl)ation in DNA topology modulation and response to DNA damage

(2019) Bakhyt T Matkarimov et al.   MUTAGENESIS

Role of PARP-catalyzed ADP-ribosylation in the Crosstalk Between DNA Strand Breaks and Epigenetic Regulation

(2019) Haser H. Sutcu et al.   JOURNAL OF MOLECULAR BIOLOGY

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

(2018) Qian Chen et al.   Nature Communications

Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism

(2018) Johannes Rudolph et al.   eLife

Structural basis for DNA break recognition by ARTD2/PARP2

(2018) Ezeogo Obaji et al.   NUCLEIC ACIDS RESEARCH

Serine ADP-Ribosylation Depends on HPF1

(2017) Juan José Bonfiglio et al.   MOLECULAR CELL

PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas

(2017) Judith Navarro et al.   Scientific Reports

Characterization of the DNA dependent activation of human ARTD2/PARP2

(2016) Ezeogo Obaji et al.   Scientific Reports

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

(2015) Jennine M. Dawicki-McKenna et al.   MOLECULAR CELL

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

(2015) Amanda A. Riccio et al.   NUCLEIC ACIDS RESEARCH

Role of PARP2 in DNA repair

(2014) M. M. Kutuzov et al.   MOLECULAR BIOLOGY

ARTD2 activity is stimulated by RNA

(2014) Karolin Léger et al.   NUCLEIC ACIDS RESEARCH

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

(2014) Marie-France Langelier et al.   NUCLEIC ACIDS RESEARCH

Binding to WGR Domain by Salidroside Activates PARP1 and Protects Hematopoietic Stem Cells from Oxidative Stress

(2013) Xue Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Interaction of PARP-2 with DNA structures mimicking DNA repair intermediates and consequences on activity of base excision repair proteins

(2013) Mikhail M. Kutuzov et al.   BIOCHIMIE

Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer

(2013) J. D. Steffen et al.   CANCER RESEARCH

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

(2013) Marie-France Langelier et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The expanding role of PARPs in the establishment and maintenance of heterochromatin

(2013) Françoise Dantzer et al.   FEBS Journal

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger

(2011) Sebastian Eustermann et al.   JOURNAL OF MOLECULAR BIOLOGY

Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin

(2011) E. Kotova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How a protein searches for its site on DNA: the mechanism of facilitated diffusion

(2009) Leonid Mirny et al.   Journal of Physics A-Mathematical and Theoretical

RNA under attack: Cellular handling of RNA damage

(2008) Elisabeth J. Wurtmann et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY