Systemic inflammation induced from remote extremity trauma is a critical driver of secondary brain injury

Tourniquet-induced ischemia creates increased risk of organ dysfunction and mortality following delayed limb amputation

(2023) Cassie J. Rowe et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Systematic Identification of the Optimal Housekeeping Genes for Accurate Transcriptomic and Proteomic Profiling of Tissues following Complex Traumatic Injury

(2023) Andrea H. Dragon et al.   Methods and Protocols

Delirium due to hip fracture is associated with activated immune-inflammatory pathways and a reduction in negative immunoregulatory mechanisms

(2022) Paul Thisayakorn et al.   BMC Psychiatry

Pathophysiology in patients with polytrauma

(2022) H.-C. Pape et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Key early proinflammatory signaling molecules encapsulated within circulating exosomes following traumatic injury

(2022) Sarah A. Walsh et al.   Journal of Inflammation-London

Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments

(2022) Nobufumi Sekino et al.   Journal of Neuroinflammation

Effects of an intravenous ketamine infusion on inflammatory cytokine levels in male and female Sprague–Dawley rats

(2022) Haley F. Spencer et al.   Journal of Neuroinflammation

Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation

(2022) Philip J. Spreadborough et al.   Journal of Orthopaedic Surgery and Research

The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest

(2022) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Reduction of neuroinflammation alleviated mouse post bone fracture and stroke memory dysfunction

(2021) Kang Huo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis

(2021) Marta Celorrio et al.   Acta Neuropathologica Communications

Blast-induced temporal alterations in blood–brain barrier properties in a rodent model

(2021) Usmah Kawoos et al.   Scientific Reports

Localizing Clinical Patterns of Blast Traumatic Brain Injury Through Computational Modeling and Simulation

(2021) Scott T. Miller et al.   Frontiers in Neurology

Alarming Cargo: The Role of Exosomes in Trauma-Induced Inflammation

(2021) Sarah A. Walsh et al.   Biomolecules

ggVennDiagram: An Intuitive, Easy-to-Use, and Highly Customizable R Package to Generate Venn Diagram

(2021) Chun-Hui Gao et al.   Frontiers in Genetics

Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation

(2021) Miguel A. Gama Sosa et al.   Acta Neuropathologica Communications

Blast traumatic brain injury and serum inflammatory cytokines: a repeated measures case-control study among U.S. military service members

(2020) Jennifer Rusiecki et al.   Journal of Neuroinflammation

Prehospital Use of Ketamine in the Combat Setting: A Sub-Analysis of Patients With Head Injuries Evaluated in the Prospective Life Saving Intervention Study

(2020) Vikhyat S Bebarta et al.   MILITARY MEDICINE

Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure

(2020) Dara L. Dickstein et al.   MOLECULAR PSYCHIATRY

Estrogen Formation and Inactivation Following TBI: What we Know and Where we Could go

(2020) Kelli A. Duncan   Frontiers in Endocrinology

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

(2020) Nathalie Percie du Sert et al.   PLOS BIOLOGY

Neuroinflammation after surgery: from mechanisms to therapeutic targets

(2020) Ting Yang et al.   NATURE IMMUNOLOGY

Blast-Related Mild TBI Alters Anxiety-Like Behavior and Transcriptional Signatures in the Rat Amygdala

(2020) Jennifer Blaze et al.   Frontiers in Behavioral Neuroscience

Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury

(2020) Aswati Aravind et al.   Frontiers in Neurology

Sex Differences in Behavioral Sensitivities After Traumatic Brain Injury

(2020) Ann N. Hoffman et al.   Frontiers in Neurology

Biomechanics of Blast TBI With Time-Resolved Consecutive Primary, Secondary, and Tertiary Loads

(2019) Andrzej Przekwas et al.   MILITARY MEDICINE

Neuroinflammation and Perioperative Neurocognitive Disorders

(2019) Saraswathi Subramaniyan et al.   ANESTHESIA AND ANALGESIA

Acute Inflammation in Traumatic Brain Injury and Polytrauma Patients Using Network Analysis

(2019) Bradley Rowland et al.   SHOCK

Systemic inflammatory response syndrome and long-term outcome after intracerebral hemorrhage

(2019) Manuel Hagen et al.   Neurology-Neuroimmunology & Neuroinflammation

Patterns of Anatomic Injury in Critically Injured Combat Casualties: A Network Analysis

(2019) Jud C. Janak et al.   Scientific Reports

Use of ketamine for prehospital pain control on the battlefield

(2019) Gaël de Rocquigny et al.   Journal of Trauma and Acute Care Surgery

Heterotopic ossification and lessons learned from fifteen years at war: A review of therapy, novel research, and future directions for military and civilian orthopaedic trauma

(2018) Benjamin W. Hoyt et al.   BONE

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

Elucidating Pro-Inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model

(2018) Eric Peter Thelin et al.   JOURNAL OF NEUROTRAUMA

Innate immune responses to trauma

(2018) Markus Huber-Lang et al.   NATURE IMMUNOLOGY

Long-term Consequences of Traumatic Brain Injury in Bone Metabolism

(2018) Nikita M. Bajwa et al.   Frontiers in Neurology

Sex-Dependent Effects of Mild Blast-induced Traumatic Brain Injury on Corticotropin-releasing Factor Receptor Gene Expression: Potential Link to Anxiety-like Behaviors

(2018) Ashley L. Russell et al.   NEUROSCIENCE

Complement After Trauma: Suturing Innate and Adaptive Immunity

(2018) Shinjini Chakraborty et al.   Frontiers in Immunology

Wounding Patterns Based on Firearm Type in Civilian Public Mass Shootings in the United States

(2018) Babak Sarani et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

Systemic Inflammatory Response Syndrome (SIRS) Score Independently Predicts Poor Outcome in Isolated Traumatic Brain Injury

(2017) Tomas Jacome et al.   Neurocritical Care

Posttraumatic administration of a sub-anesthetic dose of ketamine exerts neuroprotection via attenuating inflammation and autophagy

(2017) C.-Q. Wang et al.   NEUROSCIENCE

Multicenter, Prospective Study of Prehospital Administration of Analgesia in the U.S. Combat Theater of Afghanistan

(2017) Steven G. Schauer et al.   Prehospital Emergency Care

Traumatic Brain Injury Incidence, Clinical Overview, and Policies in the US Military Health System Since 2000

(2017) Thomas M. Swanson et al.   PUBLIC HEALTH REPORTS

The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome

(2016) Stuart J. McDonald et al.   Journal of Neuroinflammation

Dismounted Complex Blast Injuries: A Comprehensive Review of the Modern Combat Experience

(2016) Jeremy W. Cannon et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance

(2015) Adam J. Walker et al.   BEHAVIOURAL BRAIN RESEARCH

Early Characterization of Blast-related Heterotopic Ossification in a Rat Model

(2015) Ammar T. Qureshi et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Tibial Fracture Exacerbates Traumatic Brain Injury Outcomes and Neuroinflammation in a Novel Mouse Model of Multitrauma

(2015) Sandy R Shultz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation

(2015) Fengjiao Wu et al.   Journal of Neuroinflammation

Modeling acute traumatic injury

(2015) Apple P. Valparaiso et al.   JOURNAL OF SURGICAL RESEARCH

Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not?

(2015) Martijn Hofman et al.   MEDIATORS OF INFLAMMATION

Prehospital and En Route Analgesic Use in the Combat Setting: A Prospectively Designed, Multicenter, Observational Study

(2015) Lawrence N. Petz et al.   MILITARY MEDICINE

Subacute Oxidative Stress and Glial Reactivity in the Amygdala are Associated with Increased Anxiety Following Blast Neurotrauma

(2015) Venkata Siva Sai Sujith Sajja et al.   SHOCK

Blast Wave Exposure to the Extremities Causes Endothelial Activation and Damage

(2015) Abigail M. Spear et al.   SHOCK

Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury

(2015) Venkata Siva Sai Sujith Sajja et al.   Scientific Reports

The development of a rat model to investigate the formation of blast-related post-traumatic heterotopic ossification

(2015) E. M. Polfer et al.   Bone & Joint Journal

Vascular and Inflammatory Factors in the Pathophysiology of Blast-Induced Brain Injury

(2015) Gregory A. Elder et al.   Frontiers in Neurology

Military-related traumatic brain injury and neurodegeneration

(2014) Ann C. McKee et al.   Alzheimers & Dementia

Do Inflammatory Markers Portend Heterotopic Ossification and Wound Failure in Combat Wounds?

(2014) Jonathan A. Forsberg et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Systematic review of the prevalence and characteristics of battle casualties from NATO coalition forces in Iraq and Afghanistan

(2014) Rigo Hoencamp et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Cytokine Levels (IL-4, IL-6, IL-8 and TGFβ) as Potential Biomarkers of Systemic Inflammatory Response in Trauma Patients

(2014) Gershon Volpin et al.   INTERNATIONAL ORTHOPAEDICS

Extremity War Injuries VIII: Sequelae of Combat Injuries

(2014) Romney C. Andersen et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

The systemic immune response to trauma: an overview of pathophysiology and treatment

(2014) Janet M Lord et al.   LANCET

Blast neurotrauma impairs working memory and disrupts prefrontal myo-inositol levels in rats

(2014) Venkata Siva Sai Sujith Sajja et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Ketamine Effect on ICP in Traumatic Brain Injury

(2014) F. A. Zeiler et al.   Neurocritical Care

Osteogenic Gene Expression Correlates With Development of Heterotopic Ossification in War Wounds

(2013) Korboi N. Evans et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Ketamine and Peripheral Inflammation

(2013) Marc De Kock et al.   CNS Neuroscience & Therapeutics

Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast

(2013) P.M. Abdul-Muneer et al.   FREE RADICAL BIOLOGY AND MEDICINE

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(2013) Jeffrey V Rosenfeld et al.   LANCET NEUROLOGY

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(2013) David S. Plurad   MILITARY MEDICINE

Blast induces oxidative stress, inflammation, neuronal loss and subsequent short-term memory impairment in rats

(2013) H.J. Cho et al.   NEUROSCIENCE

A CD11d Monoclonal Antibody Treatment Reduces Tissue Injury and Improves Neurological Outcome after Fluid Percussion Brain Injury in Rats

(2012) Feng Bao et al.   JOURNAL OF NEUROTRAUMA

Inflammatory Cytokine and Chemokine Expression is Associated With Heterotopic Ossification in High-Energy Penetrating War Injuries

(2012) Korboi N. Evans et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Blast-induced neurotrauma leads to neurochemical changes and neuronal degeneration in the rat hippocampus

(2012) Venkata Siva Sai Sujith Sajja et al.   NMR IN BIOMEDICINE

miRDeepFinder: a miRNA analysis tool for deep sequencing of plant small RNAs

(2012) Fuliang Xie et al.   PLANT MOLECULAR BIOLOGY

CXCR2: From Bench to Bedside

(2012) Anika Stadtmann et al.   Frontiers in Immunology

Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to “composite” blast

(2012) Stanislav I. Svetlov   Frontiers in Neurology

Brain Injuries from Blast

(2011) Cameron R. Bass et al.   ANNALS OF BIOMEDICAL ENGINEERING

Increased Risk of Multiple Sclerosis after Traumatic Brain Injury: A Nationwide Population-Based Study

(2011) Jiunn-Horng Kang et al.   JOURNAL OF NEUROTRAUMA

Detection of Blast-Related Traumatic Brain Injury in U.S. Military Personnel

(2011) Christine L. Mac Donald et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of interleukin-1β in postoperative cognitive dysfunction

(2010) Mario Cibelli et al.   ANNALS OF NEUROLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Relationship between orientation to a blast and pressure wave propagation inside the rat brain

(2010) Mikulas Chavko et al.   JOURNAL OF NEUROSCIENCE METHODS

Blast injury research models

(2010) E. Kirkman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Sex differences in the brain: The relation between structure and function

(2009) Geert J. de Vries et al.   HORMONES AND BEHAVIOR

Heterotopic Ossification in High-Energy Wartime Extremity Injuries: Prevalence and Risk Factors

(2009) Jonathan Agner Forsberg et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Blast-related mild traumatic brain injury: mechanisms of injury and impact on clinical care

(2009) Gregory A. Elder et al.   MOUNT SINAI JOURNAL OF MEDICINE

Systemic Inflammation following Hind-Limb Ischemia-Reperfusion Affects Brain in Neonatal Mice

(2008) M. Daniela Bianco-Batlles et al.   DEVELOPMENTAL NEUROSCIENCE

Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury

(2008) D.P. Ankeny et al.   NEUROSCIENCE