The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα

Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

(2022) Shaza Asif et al.   Molecular Metabolism

PPAR control of metabolism and cardiovascular functions

(2021) David Montaigne et al.   Nature Reviews Cardiology

Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

(2021) Daniel Ferguson et al.   Nature Reviews Endocrinology

FAT10 promotes hepatocellular carcinoma (HCC) carcinogenesis by mediating P53 degradation and acts as a prognostic indicator of HCC

(2021) Yue Zhang et al.   Journal of Gastrointestinal Oncology

The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis

(2019) Jingjing Cai et al.   HEPATOLOGY

Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

(2019) Nava Reznik et al.   ACS Chemical Biology

Different roles of FAT10, FOXO1, and ADRA2A in hepatocellular carcinoma tumorigenesis in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH)

(2018) Yue Jia et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions

(2018) Richard Schregle et al.   IMMUNOGENETICS

Overactivated neddylation pathway in human hepatocellular carcinoma

(2018) Jian Yu et al.   Cancer Medicine

Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study

(2018) Jan Oscarsson et al.   Journal of Clinical Lipidology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

(2016) Joel T. Haas et al.   Annual Review of Physiology

The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis

(2016) Nathalie Hennuyer et al.   ATHEROSCLEROSIS

The Ubiquitin-like Protein FAT10 Stabilizes eEF1A1 Expression to Promote Tumor Proliferation in a Complex Manner

(2016) X. Liu et al.   CANCER RESEARCH

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Deregulated neddylation in liver fibrosis

(2016) Imanol Zubiete-Franco et al.   HEPATOLOGY

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Cdkn2a/p16Ink4a Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1  Pathway

(2014) K. Bantubungi et al.   DIABETES

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

(2014) Michal Pawlak et al.   HEPATOLOGY

NFκB and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53

(2014) Yongwook Choi et al.   Molecular Oncology

FAT10ylation as a signal for proteasomal degradation

(2013) Gunter Schmidtke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry

(2013) Ling Leng et al.   JOURNAL OF PROTEOME RESEARCH

FAT10 modifies p53 and upregulates its transcriptional activity

(2011) Tianwei Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Peroxisome Proliferator–Activated Receptor-α Gene Level Differently Affects Lipid Metabolism and Inflammation in Apolipoprotein E2 Knock-In Mice

(2011) Fanny Lalloyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

(2008) B. Kalveram et al.   JOURNAL OF CELL SCIENCE