Design, synthesis, and in silico studies of novel di-(2-aryl hydrozonopropanal) arene derivatives as potent anticancer for targeting A2AR and LRP6 in HCT116 cell

Exosomal miRNAs as a Promising Source of Biomarkers in Colorectal Cancer Progression

(2022) Tahani Bakhsh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

(2022) Changfa Sun et al.   Frontiers in Immunology

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

(2021) Valery M. Dembitsky et al.   MOLECULES

Trends in Colorectal Cancer Incidence Rates in Saudi Arabia (2001–2016) Using Saudi National Registry: Early- Versus Late-Onset Disease

(2021) Mesnad Alyabsi et al.   Frontiers in Oncology

Combination of Wnt/β-Catenin Targets S100A4 and DKK1 Improves Prognosis of Human Colorectal Cancer

(2021) Mathias Dahlmann et al.   Cancers

The genetic factors associated with Wnt signaling pathway in colorectal cancer

(2020) Amirsaeed Sabeti Aghabozorgi et al.   LIFE SCIENCES

Dkk1 exacerbates doxorubicin-induced cardiotoxicity by inhibiting the Wnt/β-catenin signaling pathway

(2019) Liying Liang et al.   JOURNAL OF CELL SCIENCE

CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis

(2019) Xiao-Lu Ma et al.   Journal of Hematology & Oncology

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

(2019) Antoine Daina et al.   NUCLEIC ACIDS RESEARCH

A Role for the WNT Co-Receptor LRP6 in Pathogenesis and Therapy of Epithelial Cancers

(2019) Raisch et al.   Cancers

Drug resistance and new therapies in colorectal cancer

(2018) Kevin Van der Jeught et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Artificial intelligence in drug development: present status and future prospects

(2018) Kit-Kay Mak et al.   DRUG DISCOVERY TODAY

Erratum: Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells

(2018) Joshua C. Curtin et al.   Oncotarget

An expeditious and green synthesis of new enaminones and study their chemical reactivity toward some different amines and binucleophiles under environmentally friendly conditions

(2017) Khadijah M. Al-Zaydi et al.   Arabian Journal of Chemistry

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Boosting Docking-Based Virtual Screening with Deep Learning

(2016) Janaina Cruz Pereira et al.   Journal of Chemical Information and Modeling

STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways

(2016) Bing Chen et al.   Oncotarget

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

(2011) Eric Bourhis et al.   STRUCTURE

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimized Hydrophobic Interactions and Hydrogen Bonding at the Target-Ligand Interface Leads the Pathways of Drug-Designing

(2010) Rohan Patil et al.   PLoS One

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

(2010) Yan Gong et al.   PLoS One

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors

(2008) Michael J. Boyd et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Non-Steroidal Aromatase Inhibitors Based on a Biphenyl Scaffold: Synthesis, in vitro SAR, and Molecular Modelling

(2008) Toby Jackson et al.   ChemMedChem

DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation

(2008) Mikhail V. Semënov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY