Minimizing the DILI potential of carboxylic acid-containing drugs: a perspective
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Minimizing the DILI potential of carboxylic acid-containing drugs: a perspective
Authors
Keywords
-
Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 32, Issue 9, Pages 2034-2047
Publisher
Springer Science and Business Media LLC
Online
2023-09-09
DOI
10.1007/s00044-023-03140-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration
- (2023) Billy J. Molloy et al. XENOBIOTICA
- A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites
- (2022) Nobuyuki Kakutani et al. XENOBIOTICA
- Acyl glucuronide reactivity in perspective
- (2020) Peter R. Bradshaw et al. DRUG DISCOVERY TODAY
- Benzoyl-CoA conjugate accumulation as an initiating event for male reprotoxic effects in the rat? Structure–activity analysis, species specificity, and in vivo relevance
- (2020) Heike Laue et al. ARCHIVES OF TOXICOLOGY
- Characterization of fasiglifam-related liver toxicity in dogs
- (2019) Akifumi Kogame et al. DRUG METABOLISM AND DISPOSITION
- Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester
- (2019) Jackie Shang et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Designing around Structural Alerts in Drug Discovery
- (2019) Amit S. Kalgutkar JOURNAL OF MEDICINAL CHEMISTRY
- Safety Assessment of Acyl Glucuronides—A Simplified Paradigm
- (2018) Dennis A. Smith et al. DRUG METABOLISM AND DISPOSITION
- Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans
- (2018) Akifumi Kogame et al. XENOBIOTICA
- The metabolic fate of fenclozic acid in chimeric mice with a humanized liver
- (2018) Anja Ekdahl et al. ARCHIVES OF TOXICOLOGY
- Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury
- (2017) Monicah A Otieno et al. TOXICOLOGICAL SCIENCES
- Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes
- (2015) Malin Darnell et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated
- (2015) Toni Lassila et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein
- (2014) Rune Nygaard Monrad et al. Chemical Science
- Characterization of the Acyl-Adenylate Linked Metabolite of Mefenamic Acid
- (2013) Howard Horng et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics
- (2013) Kyle S. Saitta et al. XENOBIOTICA
- Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen
- (2011) Timothy J. Woodman et al. CHEMICAL COMMUNICATIONS
- Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States
- (2011) Antonia F. Stepan et al. CHEMICAL RESEARCH IN TOXICOLOGY
- NSAID Acyl Glucuronides and Enteropathy
- (2011) Urs A. Boelsterli et al. CURRENT DRUG METABOLISM
- Determinants of Aspirin Metabolism in Healthy Men and Women: Effects of Dietary Inducers of UDP-Glucuronosyltransferases
- (2011) Sandi L. Navarro et al. Journal of Nutrigenetics and Nutrigenomics
- Diclofenac metabolism in the mouse: Novelin vivometabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry
- (2011) Sunil Sarda et al. XENOBIOTICA
- Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
- (2010) R. Sawamura et al. DRUG METABOLISM AND DISPOSITION
- Integrated HPLC-MS and1H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides
- (2009) C. H. Johnson et al. XENOBIOTICA
- Enantioselective Formation of Ibuprofen-S-Acyl-Glutathione in Vitro in Incubations of Ibuprofen with Rat Hepatocytes†
- (2008) Mark P. Grillo et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity
- (2008) H. Takakusa et al. DRUG METABOLISM AND DISPOSITION
- A Novel Bioactivation Pathway for 2-[2-(2,6-Dichlorophenyl)aminophenyl]ethanoic Acid (Diclofenac) Initiated by Cytochrome P450-Mediated Oxidative Decarboxylation
- (2008) M. P. Grillo et al. DRUG METABOLISM AND DISPOSITION
- Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review
- (2008) M. F. B. Silva et al. JOURNAL OF INHERITED METABOLIC DISEASE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started