The metabolic fate of fenclozic acid in chimeric mice with a humanized liver

Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid

(2017) James A. Akingbasote et al.   Toxicology Research

Acute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice

(2016) Kathryn Pickup et al.   ARCHIVES OF TOXICOLOGY

Reactive Metabolites: Current and Emerging Risk and Hazard Assessments

(2016) Richard A. Thompson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity

(2016) Nico Scheer et al.   DRUG DISCOVERY TODAY

Methanol adducts leading to the identification of a reactive aldehyde metabolite of CPAQOP in human liver microsomes by ultra-high-performance liquid chromatography/mass spectrometry

(2016) Scott Martin et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes

(2015) Malin Darnell et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of the Reactive Metabolites of Fenclozic Acid in Bile Duct Cannulated Rats

(2014) Scott Martin et al.   ANALYTICAL CHEMISTRY

In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid

(2013) Alison V. M. Rodrigues et al.   ARCHIVES OF TOXICOLOGY

Metabolism of Xenobiotic Carboxylic Acids: Focus on Coenzyme A Conjugation, Reactivity, and Interference with Lipid Metabolism

(2013) Malin Darnell et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse

(2013) Kathryn Pickup et al.   XENOBIOTICA

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

(2012) Richard A. Thompson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites

(2010) Hidetaka Kamimura et al.   Drug Metabolism and Pharmacokinetics

A Novel Bioactivation Pathway for 2-[2-(2,6-Dichlorophenyl)aminophenyl]ethanoic Acid (Diclofenac) Initiated by Cytochrome P450-Mediated Oxidative Decarboxylation

(2008) M. P. Grillo et al.   DRUG METABOLISM AND DISPOSITION