Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

(2016) Fiona C. Brownfoot et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production1

(2016) Kirsten R. Palmer et al.   BIOLOGY OF REPRODUCTION

Ectodomain cleavage of FLT1 regulates receptor activation and function and is not required for its downstream intracellular cleavage

(2016) Nandita S. Raikwar et al.   EXPERIMENTAL CELL RESEARCH

Prediction of preeclampsia with angiogenic biomarkers. Results from the prospective Odense Child Cohort

(2016) Louise Bjørkholt Andersen et al.   HYPERTENSION IN PREGNANCY

Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia

(2016) Kirsten R. Palmer et al.   Journal of Maternal-Fetal & Neonatal Medicine

Pre-eclampsia

(2016) Ben W J Mol et al.   LANCET

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

(2016) Harald Zeisler et al.   NEW ENGLAND JOURNAL OF MEDICINE

sFlt-1/PlGF ratio test for pre-eclampsia: an economic assessment for the UK

(2016) M. Vatish et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Diagnostic accuracy of the soluble Fms-like tyrosine kinase-1/placental growth factor ratio for preeclampsia: a meta-analysis based on 20 studies

(2015) Yuxiu Liu et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Preeclampsia: Syndrome or Disease?

(2015) Leslie Myatt et al.   CURRENT HYPERTENSION REPORTS

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe PreeclampsiaNovelty and Significance

(2015) Fiona C. Brownfoot et al.   HYPERTENSION

Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia

(2015) Colby Souders et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia

(2015) R. Thadhani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

(2015) Fiona C. Brownfoot et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1

(2015) C. Li et al.   PLACENTA

Full-Length Human Placental sFlt-1-e15a Isoform Induces Distinct Maternal Phenotypes of Preeclampsia in Mice

(2015) Gabor Szalai et al.   PLoS One

Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway

(2014) Sarosh Rana et al.   FASEB JOURNAL

In Vivo Experiments Reveal the Good, the Bad and the Ugly Faces of sFlt-1 in Pregnancy

(2014) Gabor Szalai et al.   PLoS One

N-Terminal Cleavage and Release of the Ectodomain of Flt1 Is Mediated via ADAM10 and ADAM 17 and Regulated by VEGFR2 and the Flt1 Intracellular Domain

(2014) Nandita S. Raikwar et al.   PLoS One

Global causes of maternal death: a WHO systematic analysis

(2014) Lale Say et al.   Lancet Global Health

Gestational angiogenic biomarker patterns in high risk preeclampsia groups

(2013) Sharon E. Maynard et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Vasoactive agents for the prediction of early- and late-onset preeclampsia in a high-risk cohort

(2013) Pia M Villa et al.   BMC Pregnancy and Childbirth

Angiogenic factors as diagnostic tests for preeclampsia: a performance comparison between two commercial immunoassays

(2011) Samantha J. Benton et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia

(2011) CL Whitehead et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia

(2011) Stefan Verlohren et al.   CLINICAL SCIENCE

Expression of Placental FLT1 Transcript Variants Relates to Both Gestational Hypertensive Disease and Fetal Growth

(2011) Jiska Jebbink et al.   HYPERTENSION

Proteinuria and hypertension with tyrosine kinase inhibitors

(2011) Praveen Kandula et al.   KIDNEY INTERNATIONAL

A Critical Review of Early-Onset and Late-Onset Preeclampsia

(2011) Dahlia Raymond et al.   OBSTETRICAL & GYNECOLOGICAL SURVEY

Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1

(2011) J.-N. Boeckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Hypoxia-Inducible Factor-1α Overexpression in Pregnant Mice

(2010) Reshef Tal et al.   AMERICAN JOURNAL OF PATHOLOGY

Multicenter evaluation of the first automated Elecsys sFlt-1 and PlGF assays in normal pregnancies and preeclampsia

(2010) J. Schiettecatte et al.   CLINICAL BIOCHEMISTRY

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET

Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

(2010) K. Kumasawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenic dysfunction in molar pregnancy

(2009) David Kanter et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Identification of Ligand-Induced Proteolytic Cleavage and Ectodomain Shedding of VEGFR-1/FLT1 in Leukemic Cancer Cells

(2009) N. Rahimi et al.   CANCER RESEARCH

Elevated serum soluble fms-like tyrosine kinase 1 (sFlt1) level in women with hydatidiform mole

(2009) Kaori Koga et al.   FERTILITY AND STERILITY

Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model

(2009) Astrid Bergmann et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Gadd45a stress signaling regulates sFlt-1 expression in preeclampsia

(2009) Yali Xiong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Recently Evolved Novel Trophoblast-Enriched Secreted Form of fms-Like Tyrosine Kinase-1 Variant Is Up-Regulated in Hypoxia and Preeclampsia

(2009) Christie P. Thomas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel Splice Variants of sFlt1 are Upregulated in Preeclampsia

(2009) M. Heydarian et al.   PLACENTA

Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia?

(2008) Yuval Bdolah et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

A Novel Human-Specific Soluble Vascular Endothelial Growth Factor Receptor 1

(2008) Shay Sela et al.   CIRCULATION RESEARCH

VEGF Inhibition and Renal Thrombotic Microangiopathy

(2008) Vera Eremina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placental Productions and Expressions of Soluble Endoglin, Soluble fms-Like Tyrosine Kinase Receptor-1, and Placental Growth Factor in Normal and Preeclamptic Pregnancies

(2007) Yang Gu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM