CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

The centrosomal component CEP161 ofDictyostelium discoideuminteracts with the Hippo signaling pathway

(2015) Salil K. Sukumaran et al.   CELL CYCLE

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

(2015) Qian Chen et al.   GENES & DEVELOPMENT

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2

(2015) Hiroshi Hanafusa et al.   NATURE CELL BIOLOGY

Centrosome function and assembly in animal cells

(2015) Paul T. Conduit et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Survivin – The inconvenient IAP

(2015) Dario C. Altieri   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mutations inCDK5RAP2cause Seckel syndrome

(2015) Gökhan Yigit et al.   Molecular Genetics & Genomic Medicine

The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap

(2014) A. Lavado et al.   DEVELOPMENT

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

Small organelle, big responsibility: the role of centrosomes in development and disease

(2014) P. L. Chavali et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators

(2013) A. Lavado et al.   DEVELOPMENT

CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly

(2013) Muhammad S. Hussain et al.   HUMAN MOLECULAR GENETICS

Clinical and cellular features in patients with primary autosomal recessive microcephaly and a novel CDK5RAP2 mutation

(2013) Lina Issa et al.   Orphanet Journal of Rare Diseases

A Truncating Mutation of CEP135 Causes Primary Microcephaly and Disturbed Centrosomal Function

(2012) Muhammad Sajid Hussain et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A novel nonsenseCDK5RAP2mutation in a Somali child with primary microcephaly and sensorineural hearing loss

(2012) Alistair T. Pagnamenta et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

LINC complex alterations in DMD and EDMD/CMT fibroblasts

(2012) Surayya Taranum et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

(2012) Wesley M. Konsavage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Centrosome in Cells and Organisms

(2012) M. Bornens   SCIENCE

Primary microcephaly 3 (MCPH3): Revisiting two critical mutations

(2011) John S.Y. Park et al.   CELL CYCLE

What’s the hype about CDK5RAP2?

(2011) Nadine Kraemer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

(2011) Sandra Habbig et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties

(2010) Angela M. Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CDK5RAP2 is required for spindle checkpoint function

(2010) Xiaoying Zhang et al.   CELL CYCLE

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

(2010) S. B. Lizarraga et al.   DEVELOPMENT

CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice

(2010) Jose A. Barrera et al.   DEVELOPMENTAL CELL

Conserved Motif of CDK5RAP2 Mediates Its Localization to Centrosomes and the Golgi Complex

(2010) Zhe Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response

(2010) Alexis R. Barr et al.   JOURNAL OF CELL BIOLOGY

Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

(2010) Balca R. Mardin et al.   NATURE CELL BIOLOGY

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MST1 and hMOB1 Tumor Suppressors Control Human Centrosome Duplication by Regulating NDR Kinase Phosphorylation

(2009) Alexander Hergovich et al.   CURRENT BIOLOGY

Interaction of CDK5RAP2 with EB1 to Track Growing Microtubule Tips and to Regulate Microtubule Dynamics

(2009) Ka-Wing Fong et al.   MOLECULAR BIOLOGY OF THE CELL

Many roads lead to primary autosomal recessive microcephaly

(2009) Angela M. Kaindl et al.   PROGRESS IN NEUROBIOLOGY

YAP regulates neural progenitor cell number via the TEA domain transcription factor

(2008) X. Cao et al.   GENES & DEVELOPMENT

CDK5RAP2 Is a Pericentriolar Protein That Functions in Centrosomal Attachment of the γ-Tubulin Ring Complex

(2007) Ka-Wing Fong et al.   MOLECULAR BIOLOGY OF THE CELL