Article
Endocrinology & Metabolism
Rensiqin Wu, Hui Wang, Jian Huangfu, Rui Xiao
Summary: Inhibition of A-FABP expression can increase cell proliferation activity and reduce PTEN expression in induced 3T3-L1 cells, suggesting A-FABP plays a crucial role in regulating AKT activity during adipocyte differentiation.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Renli Qi, Xu Han, Jing Wang, Xiaoyu Qiu, Qi Wang, Feiyun Yang
Summary: The study revealed that miR-489 is highly expressed in the fat tissue of mice, and its overexpression inhibits cell proliferation but promotes adipogenic differentiation and lipid accumulation. By targeting the Postn gene, miR-489 plays a crucial role in adipocyte differentiation and metabolism, which could potentially contribute to obesity treatment.
Article
Biochemistry & Molecular Biology
Yifen Wang, Jie Zhang, Xueru Chu, Mengke Wang, Yongning Xin, Shousheng Liu
Summary: This study found that miR-146a-5p regulates the differentiation of 3T3-L1 cells by targeting the ErbB4 gene and modulating the ERK1/2/PPAR-gamma signaling pathway.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Agriculture, Dairy & Animal Science
Zixuan Cheng, Xihe Li, Siqin Bao, Takahisa Yamada, Guifang Cao, Jianfeng Liu, Aorigele Chen, Bin Tong
Summary: Overexpression of CDC10 in bovine intramuscular preadipocytes and 3T3-L1 cells promotes adipocyte differentiation, while knockdown of CDC10 has the opposite effect. These findings provide new insights into the regulatory role of CDC10 in adipocytes in animals.
Article
Toxicology
Elvis Ticiani, Yong Pu, Madison White, Victoria Adomshick, Almudena Veiga-Lopez
Summary: Butyltins and phenyltins, widely used organometallic chemicals, have been found to stimulate adipogenic differentiation. Among them, tributyltin (TBT) is the most potent inducer, followed by triphenyltin (TPT) and dibutyltin (DBT). However, TPT and DBT can weaken the adipogenic effect of TBT. These findings indicate the antagonistic effects among organotins and the involvement of PPAR gamma signaling in their adipogenic outcomes.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Yuyang Lei, Fangfang Li, Monika Mortimer, Zhi Li, Bi-Xia Peng, Minjie Li, Liang-Hong Guo, Guoqiang Zhuang
Summary: Antibiotics as emerging environmental contaminants have adverse effects on lipid metabolism, but the underlying toxicological mechanisms are still unclear.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Daniel Heller-Trulli, Huiyun Liu, Srimoyee Mukherjee, Claire L. L. Moore
Summary: This study reveals the important role of Ube3d in cellular differentiation and its effect on mRNA processing. Knockout of Ube3d inhibits the differentiation of 3T3-L1 cells into mature adipocytes and leads to global changes in mRNA levels. Overexpression of UBE3D or CPSF73 can rescue the differentiation defect and partially restore protein levels.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Genetics & Heredity
Jiahao Shao, Ting Pan, Jie Wang, Tao Tang, Yanhong Li, Xianbo Jia, Songjia Lai
Summary: miR-208b expression in preadipocytes can influence their proliferation and differentiation, with overexpression associated with higher levels of PPAR gamma and FABP4 expression, as well as increased lipid droplet formation. Additionally, miR-208b promotes cell proliferation and may be involved in multiple signaling pathways through targeting CSNK2A2.
Article
Biochemistry & Molecular Biology
Beth A. Griesel, Satoshi Matsuzaki, Albert Batushansky, Timothy M. Griffin, Kenneth M. Humphries, Ann Louise Olson
Summary: This study using 3T3-L1 adipocytes as a model system found that an increase in glucose uptake during the first 3 days of differentiation promoted the expansion of the adipocyte metabolome and proteome. The positive effects were specifically due to increased expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), highlighting its critical role in regulating cellular metabolic remodeling for adipocyte differentiation and maturation.
Article
Biotechnology & Applied Microbiology
Ying Wu, Zhe Wang, Lu Han, Zhihao Guo, Bohua Yan, Lili Guo, Huadong Zhao, Mengying Wei, Niuniu Hou, Jing Ye, Zhe Wang, Changhong Shi, Suling Liu, Ceshi Chen, Suning Chen, Ting Wang, Jun Yi, JianPing Zhou, Libo Yao, Wenxia Zhou, Rui Ling, Jian Zhang
Summary: Cancer cells regulate their response to the chemotherapeutic drug doxorubicin through RNA m6A modification. They do this by inhibiting RNA m6A modification through PRMT5 and enhancing the nuclear translocation of the demethylase ALKBH5. This leads to increased DNA repair ability and decreased efficacy of doxorubicin. The approved drug tadalafil was identified as a PRMT5 inhibitor that could enhance doxorubicin sensitivity in breast cancer cells by decreasing RNA m6A methylation.
Article
Pharmacology & Pharmacy
Trang Thi Huyen Dang, Minji Choi, Huong Giang Pham, Jong Won Yun
Summary: Studies have shown that CYP2F2 can negatively regulate lipid metabolism and browning in adipocytes by inhibiting the activation of β-3 adrenergic receptor and its downstream regulators. Inhibitors of CYP2F2 could potentially be used as drugs for treating obesity by enhancing energy expenditure.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Vliora, Elisabetta Grillo, Michela Corsini, Cosetta Ravelli, Eleni Nintou, Eleni Karligiotou, Andreas D. Flouris, Stefania Mitola
Summary: Irisin affects mitochondrial respiration and lipolysis in a time-dependent manner through the regulation of PI3K-AKT pathway. Irisin also induces the expression of UCP1 and the regulation of NF-kappa B, and CREB and ERK pathways.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Biochemistry & Molecular Biology
Shunsuke Kimura, Ai Tsuruma, Eisuke Kato
Summary: Expression of taste 2 receptor (T2R) genes has been observed in mouse white adipose tissue and 3T3-L1 adipocytes. Fasting and bitter compounds stimulation increases Tas2r expression in mouse white adipose tissue, while serum starvation and bitter compounds stimulation increases Tas2r gene expression in 3T3-L1 adipocytes. Tas2r126 may play a role in adipocyte differentiation, as suggested by RNA sequencing analysis and overexpression studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Biotechnology & Applied Microbiology
Jia-Xiang Zhang, Pei-Jie Huang, Da-Peng Wang, Wen-Yu Yang, Jian Lu, Yong Zhu, Xiao-Xiao Meng, Xin Wu, Qiu-Hai Lin, Hui Lv, Hui Xie, Rui-Lan Wang
Summary: The study reveals the critical role of m6A modification in pulmonary fibrosis, suggesting that manipulating m6A modification through targeting METTL3 may be a promising strategy for the treatment of pulmonary fibrosis.
Article
Multidisciplinary Sciences
Yii-Shyuan Chen, Rui Wu, Xiaosong Yang, Shuping Kou, Ormond A. MacDougald, Liqing Yu, Hang Shi, Bingzhong Xue
SCIENTIFIC REPORTS
(2016)
Article
Integrative & Complementary Medicine
Ning-hua Wu, Zhi-qiang Ke, Shan Wu, Xiao-song Yang, Qing-jie Chen, Sheng-tang Huang, Chao Liu
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Biotechnology & Applied Microbiology
Huiting Song, Jiashu Liu, Yang Liu, Huan Leng, Xu Li, Yong Zhao, Xiaosong Yang, Zhengbing Jiang
ANNALS OF MICROBIOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
Mengyuan Liu, Yi Huang, Lei Hu, Guoping Liu, Xueping Hu, Dongxu Liu, Xiaosong Yang
Article
Cell Biology
Xiao-song Yang, Meng-yuan Liu, Hai-mou Zhang, Bing-zhong Xue, Hang Shi, Dong-xu Liu
INFLAMMATION RESEARCH
(2014)
Article
Biotechnology & Applied Microbiology
Mengyuan Liu, Mian Xie, Sijing Jiang, Guoping Liu, Lujun Li, Dongxu Liu, Xiaosong Yang
JOURNAL OF BIOTECHNOLOGY
(2014)
Article
Endocrinology & Metabolism
Xiaosong Yang, Xianfeng Wang, Dongxu Liu, Liqing Yu, Bingzhong Xue, Hang Shi
MOLECULAR ENDOCRINOLOGY
(2014)
Article
Cardiac & Cardiovascular Systems
Qing Yao, Zhi-qiang Ke, Shuang Guo, Xiao-song Yang, Fei-xue Zhang, Xiu-fen Liu, Xiao Chen, Hong-guang Chen, Huan-ya Ke, Chao Liu
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Article
Endocrinology & Metabolism
Jing Li, Ninghua Wu, Xiao Chen, Hongguang Chen, Xiaosong Yang, Chao Liu
Article
Biochemistry & Molecular Biology
Xiaosong Yang, Pengjie Zhang, Feixue Zhang, Zhiqiang Ke, Qingjie Chen, Chao Liu
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Plant Sciences
Xiang-wen Meng, Can-xia He, Xiao Chen, Xiao-song Yang, Chao Liu
Summary: This study found that the extract of Gnaphalium affine D. Don significantly improved cardiomyocyte viability and exhibited antioxidant effects by regulating various proteins and genes to alleviate oxidative stress and reduce cell apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chun Wang, Ling Hu, Shuang Guo, Qing Yao, Xiufen Liu, Bo Zhang, Xiangwen Meng, Xiaosong Yang
Summary: Myocardial apoptosis and necroptosis are key factors in doxorubicin-induced cardiotoxicity, while phosphocreatine (PCr) has been shown to have cardioprotective effects. PCr can alleviate myocardial cell death induced by DOX by increasing antioxidant activity, and activate the TAK1 signaling pathway to promote myocardial survival.
Article
Endocrinology & Metabolism
Jia Jing, Fenfen Li, Lin Zha, Xiaosong Yang, Rui Wu, Shirong Wang, Bingzhong Xue, Hang Shi
Article
Chemistry, Multidisciplinary
Shuang Guo, Xiang-wen Meng, Xiao-song Yang, Xiu-fen Liu, Chang-han Ou-Yang, Chao Liu
ACTA PHARMACOLOGICA SINICA
(2018)