Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

A single chain fragment constant ( scFc ) design enables easy production of a monovalent BBB transporter and provides an improved brain uptake at elevated doses

(2023) J. I. Morrison et al.   JOURNAL OF NEUROCHEMISTRY

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer’s Disease Mice

(2022) Fadi Rofo et al.   Neurotherapeutics

Trial of Prasinezumab in Early-Stage Parkinson’s Disease

(2022) Gennaro Pagano et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Cinpanemab in Early Parkinson’s Disease

(2022) Anthony E. Lang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

(2022) Sahar Roshanbin et al.   Pharmaceutics

Lecanemab in Early Alzheimer’s Disease

(2022) Christopher H. van Dyck et al.   NEW ENGLAND JOURNAL OF MEDICINE

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

(2021) Roberta Cascella et al.   Nature Communications

Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

(2021) Luis M. A. Oliveira et al.   npj Parkinsons Disease

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

(2021) Fadi Rofo et al.   Translational Neurodegeneration

Treating Parkinson’s Disease with Antibodies: Previous Studies and Future Directions

(2020) Anne-Marie Castonguay et al.   Journal of Parkinsons Disease

How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology

(2020) Senthil T. Kumar et al.   NEUROBIOLOGY OF DISEASE

Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo

(2019) Darren J. Schofield et al.   NEUROBIOLOGY OF DISEASE

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways

(2017) Leire Almandoz-Gil et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1

(2016) Michel Brahic et al.   ACTA NEUROPATHOLOGICA

Dopaminergic Neurons and Brain Reward Pathways

(2016) Sarah X. Luo et al.   AMERICAN JOURNAL OF PATHOLOGY

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

(2016) Emma Deas et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of linker length between variable domains of single chain variable fragment antibody against daidzin on its reactivity

(2016) Gorawit Yusakul et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers

(2016) Patrick J. Salveson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation

(2015) Hang Yu et al.   JOURNAL OF CHEMICAL PHYSICS

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Sequestration of a β-Hairpin for Control of α-Synuclein Aggregation

(2014) Ewa A. Mirecka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity

(2014) Eric S. Luth et al.   BIOCHEMISTRY

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

(2012) María Soledad Celej et al.   BIOCHEMICAL JOURNAL

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Alpha-Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection

(2010) He-Jin Lee et al.   Oxidative Medicine and Cellular Longevity

Structural Properties of Pore-Forming Oligomers of α-Synuclein

(2009) Hai-Young Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clearance and deposition of extracellular α-synuclein aggregates in microglia

(2008) He-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS