Comparative bioinformatic analysis of KRAS, STK11 and KEAP1 (co-)mutations in non-small cell lung cancer with a special focus on KRAS G12C

Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer

(2023) Lingzhi Hong et al.   Nature Communications

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

(2022) Bastien Nguyen et al.   CELL

The Role of TP53 Mutations in EGFR-Mutated Non-Small-Cell Lung Cancer: Clinical Significance and Implications for Therapy

(2022) Matteo Canale et al.   Cancers

STK11 and KEAP1 Mutations in Lung Adenocarcinoma: Solving the Puzzle Continues

(2022) Rafal Dziadziuszko   Journal of Thoracic Oncology

Bone-specific response according to MDA criteria predicts immunotherapy efficacy among advanced non-small cell lung cancer (NSCLC) patients

(2022) Andrea De Giglio et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C Mutation

(2022) Pasi A. Jänne et al.   NEW ENGLAND JOURNAL OF MEDICINE

Landscape of somatic alterations in large-scale solid tumors from an Asian population

(2022) Liqun Wu et al.   Nature Communications

OA15.04 Association Between KRAS/STK11/KEAP1 Mutations and Outcomes in POSEIDON: Durvalumab ± Tremelimumab + Chemotherapy in mNSCLC

(2022) S. Peters et al.   Journal of Thoracic Oncology

STK11 and KEAP1 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value among Hispanics (STRIKE registry-CLICaP)

(2022) Vladmir C. Cordeiro de Lima et al.   LUNG CANCER

Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell lines

(2022) Myriam Boeschen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

(2022) Rexhina Vlashi et al.   Genes and Diseases

Bone Metastases, Skeletal-Related Events, and Survival in Patients With Metastatic Non–Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors

(2021) Angel Qin et al.   Journal of the National Comprehensive Cancer Network

Sotorasib for Lung Cancers with KRAS p.G12C Mutation

(2021) Ferdinandos Skoulidis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oncogene-specific differences in tumor mutational burden, PD-L1 expression, and outcomes from immunotherapy in non-small cell lung cancer

(2021) Marcelo V Negrao et al.   Journal for ImmunoTherapy of Cancer

STK11/LKB1 and KEAP1 mutations in non-small cell lung cancer: Prognostic rather than predictive?

(2021) Alessandro Di Federico et al.   EUROPEAN JOURNAL OF CANCER

Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status

(2021) Biagio Ricciuti et al.   Journal of Thoracic Oncology

KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden

(2020) D. Marinelli et al.   ANNALS OF ONCOLOGY

PRMT5/Wnt4 axis promotes lymph-node metastasis and proliferation of laryngeal carcinoma

(2020) Nan Wang et al.   Cell Death & Disease

WNT4 secreted by tumor tissues promotes tumor progression in colorectal cancer by activation of the Wnt/β-catenin signalling pathway

(2020) Dongmei Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

(2020) Corrin A. Wohlhieter et al.   Cell Reports

Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11

(2019) Linnéa La Fleur et al.   LUNG CANCER

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry

(2019) J Mazières et al.   ANNALS OF ONCOLOGY

LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma

(2019) Ana Galan-Cobo et al.   CANCER RESEARCH

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

(2019) Jude Canon et al.   NATURE

Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer

(2019) Lorenza Landi et al.   Journal for ImmunoTherapy of Cancer

TP53,STK11andEGFRMutations Predict Tumor Immune Profile and the Response to anti-PD-1 in Lung Adenocarcinoma

(2018) Jerome Biton et al.   CLINICAL CANCER RESEARCH

Does nivolumab for progressed metastatic lung cancer fulfill its promises? An efficacy and safety analysis in 20 general hospitals

(2018) Kurt G. Tournoy et al.   LUNG CANCER

STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarcinoma

(2018) Ferdinandos Skoulidis et al.   Cancer Discovery

LKB1/STK11 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value

(2017) Francesco Facchinetti et al.   LUNG CANCER

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

The challenges of tumor genetic diversity

(2016) Edmund A. Mroz et al.   CANCER

A Landscape of Pharmacogenomic Interactions in Cancer

(2016) Francesco Iorio et al.   CELL

WNT4 mediates the autocrine effects of growth hormone in mammary carcinoma cells

(2016) Cécile M Vouyovitch et al.   ENDOCRINE-RELATED CANCER

The potential utility of re-mining results of somatic mutation testing: KRAS status in lung adenocarcinoma

(2016) Anna Biernacka et al.   Cancer Genetics

Wnt signaling pathway: Implications for therapy in lung cancer and bone metastasis

(2014) Yongming Xi et al.   CANCER LETTERS

Evidence for tankyrases as antineoplastic targets in lung cancer

(2013) Alexander M Busch et al.   BMC CANCER

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Regulation of Breast Cancer-induced Bone Lesions by β-Catenin Protein Signaling

(2011) Yan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

(2009) Don X. Nguyen et al.   CELL

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA