Inhibiting the pro-tumor and transcription factor FACT: Mechanisms

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

(2015) Daniel R. Carter et al.   Science Translational Medicine

Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells

(2015) Henry Garcia et al.   Oncotarget

Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer

(2015) Catherine Burkhart et al.   Oncotarget

Gene Expression Levels as Predictive Markers of Outcome in Pancreatic Cancer after Gemcitabine-Based Adjuvant Chemotherapy

(2015) Hayato Fujita et al.   NEOPLASIA

Cancer stem cells: perspectives for therapeutic targeting

(2014) Cristina Maccalli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer stem cells - important players in tumor therapy resistance

(2014) Selcuk Colak et al.   FEBS Journal

Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers

(2013) Henry Garcia et al.   Cell Reports

Targeting FACT Complex Suppresses Mammary Tumorigenesis in Her2/neu Transgenic Mice

(2012) I. E. Koman et al.   Cancer Prevention Research

Quinacrine-Mediated Autophagy and Apoptosis in Colon Cancer Cells Is Through a p53- and p21-Dependent Mechanism

(2012) Purusottam Mohapatra et al.   ONCOLOGY RESEARCH

The role of FACT in making and breaking nucleosomes

(2011) Tim Formosa   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Anti-malaria drug blocks proteotoxic stress response: Anti-cancer implications

(2011) Nickolay Neznanov et al.   CELL CYCLE

Curaxins: A New Family of Non-genotoxic Multitargeted Anticancer Agents

(2011) Valeria Di Bussolo et al.   ChemMedChem

Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity

(2011) Ranjan Preet et al.   INTERNATIONAL JOURNAL OF CANCER

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

(2011) L. V. Sequist et al.   Science Translational Medicine

Untangling the unfolded protein response

(2010) Emma L. Davenport et al.   CELL CYCLE

Quinacrine Enhances Cisplatin-Induced Cytotoxicity in Four Cancer Cell Lines

(2010) Yixiang Wang et al.   CHEMOTHERAPY

Recent Advances in Neuroblastoma

(2010) John M. Maris   NEW ENGLAND JOURNAL OF MEDICINE

New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents

(2009) Katerina Gurova   Future Oncology

9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways

(2009) C Guo et al.   ONCOGENE

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

(2008) Amit Kulkarni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Small-Molecule Inhibitor Which Reactivates p53 in Human T-Cell Leukemia Virus Type 1-Transformed Cells

(2008) K.-J. Jung et al.   JOURNAL OF VIROLOGY