Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan

Validity of Diagnostic Algorithms for Inflammatory Bowel Disease in Japanese Hospital Claims Data

(2022) Sayumi Takahashi et al.   International Journal of Environmental Research and Public Health

New and Emerging Treatments for Inflammatory Bowel Disease

(2022) Masaaki Higashiyama et al.   DIGESTION

Comparison of bleeding following gastrointestinal endoscopic biopsy in patients treated with and without direct oral anticoagulants

(2022) Takaaki Konish et al.   Endoscopy International Open

IgG4-related diseases of the digestive tract

(2021) J.-Matthias Löhr et al.   Nature Reviews Gastroenterology & Hepatology

Review article: opportunities to improve and expand thiopurine therapy for autoimmune hepatitis

(2020) Albert J. Czaja   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Genotype-based Treatment With Thiopurine Reduces Incidence of Myelosuppression in Patients With Inflammatory Bowel Diseases

(2019) Ji Young Chang et al.   Clinical Gastroenterology and Hepatology

High-resolution melt analysis enables simple genotyping of complicated polymorphisms of codon 18 rendering the NUDT15 diplotype

(2019) Yoichi Kakuta et al.   JOURNAL OF GASTROENTEROLOGY

NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study

(2018) Yoichi Kakuta et al.   JOURNAL OF GASTROENTEROLOGY

More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing

(2017) Mark M. T. J. Broekman et al.   INFLAMMATORY BOWEL DISEASES

Association between TPMT*3C and decreased thiopurine S-methyltransferase activity in patients with neuromyelitis optica spectrum disorders in China

(2017) Xiaoqing Gong et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping

(2017) Yoichi Kakuta et al.   JOURNAL OF GASTROENTEROLOGY

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia

(2017) Takaya Moriyama et al.   Pharmacogenetics and Genomics

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

(2016) Nicholas C.K. Valerie et al.   CANCER RESEARCH

Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age

(2016) Hisato Suzuki et al.   JOURNAL OF HUMAN GENETICS

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

(2016) Takaya Moriyama et al.   NATURE GENETICS

Susceptibility to 6-MP toxicity conferred by aNUDT15variant in Japanese children with acute lymphoblastic leukaemia

(2015) Yoichi Tanaka et al.   BRITISH JOURNAL OF HAEMATOLOGY

NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD

(2015) Y Kakuta et al.   PHARMACOGENOMICS JOURNAL

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

(2014) Suk-Kyun Yang et al.   NATURE GENETICS

Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come

(2010) L. T. Ford et al.   JOURNAL OF CLINICAL PATHOLOGY

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment

(2009) Kan Uchiyama et al.   JOURNAL OF GASTROENTEROLOGY

Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease

(2009) Noritaka Takatsu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Analysis of Thiopurine S-Methyltransferase Genotypes in Japanese Patients with Inflammatory Bowel Disease

(2008) Hiromitsu Ban et al.   INTERNAL MEDICINE

Azathioprine in Multiple Sclerosis

(2008) Paolo Invernizz et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity

(2008) Rebecca L. Roberts et al.   Pharmacogenetics and Genomics