Article
Cell Biology
Yuji Shiozaki, Shinobu Miyazaki-Anzai, Audrey L. Keenan, Makoto Miyazaki
Summary: Amino acid deficiency can mimic starvation to induce FAM134B2 expression, with MEF2D and NR4A1 identified as critical transcription factors involved. Integrated signal response and mTOR signals do not contribute to the induction of FAM134B2 under amino acid deficiency.
Editorial Material
Biochemistry & Molecular Biology
Yao Yao
Summary: Microglia have both pro-inflammatory and anti-inflammatory roles in stroke. A study in PLOS Biology reveals that the transcription factor NR4A1 negatively regulates TNF expression in microglia through a new mechanism.
Article
Cell Biology
Jeremy F. Brooks, Corey Tan, James L. Mueller, Kenta Hibiya, Ryosuke Hiwa, Vivasvan Vykunta, Julie Zikherman
Summary: The expression of the nuclear receptor NUR77/Nr4a1 in B cells is associated with antigen stimulation and helps restrain B cell expansion. NUR77 plays a role in regulating GC size, particularly in curbing immunodominance under conditions of diverse clonal populations competing for a limited niche.
Article
Biochemistry & Molecular Biology
Kumaravel Mohankumar, Rupesh Shrestha, Stephen Safe
Summary: The study revealed that PSPC1 is crucial in cancer cells, with NR4A1 acting as a key regulator of PSPC1. NR4A1 antagonists inhibit tumor growth by downregulating PSPC1 and suppressing pro-oncogenic activities.
MOLECULAR CARCINOGENESIS
(2022)
Review
Medicine, General & Internal
Nai-Wen Su, Yu-Jen Chen
Summary: Metronomic therapy is a low-dose, repeated treatment approach for cancer that targets antiangiogenesis and immunomodulation mechanisms, showing comparative efficacy to traditional chemotherapy but with reduced side effects. In the treatment of oral cavity squamous cell carcinoma and other cancers, metronomic therapy has demonstrated promising results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Leonardo de Oliveira da Rocha, Bruno Solano de Freitas Souza, Ricardo Della Coletta, Daniel W. Lambert, Clarissa A. Gurgel Rocha
Summary: Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In this study, spheroids obtained from OSCC and cancer-associated fibroblast (CAF) lines were used to investigate CIC structures. The spheroids showed the morphological aspects of the tumor microenvironment and CIC structures were found in both homotypic and heterotypic groups, predominantly in the proliferative zone of mixed spheroids. Complex cannibalism events were also observed. This model has the potential for further studies on CIC morphology, formation, and its relationship with tumor prognosis.
Review
Oncology
Leonardo Di Gennaro, Raimondo De Cristofaro, Antonietta Ferretti, Maria Basso, Claudia Riccio, Massimo Cordaro, Carlo Lajolo
Summary: This review discusses the relationship between oral squamous cell carcinoma (OSCC) and venous thromboembolism (VTE). VTE has a significant impact on the mortality rate of cancer patients, and the thrombotic risk in OSCC patients has not been extensively studied, leading to insufficient prevention measures and affecting the effectiveness of oncologic treatment.
Review
Oncology
Leonardo de Oliveira Siquara da Rocha, Bruno Solano de Freitas Souza, Daniel W. Lambert, Clarissa de Araujo Gurgel Rocha
Summary: Cell-in-cell structures are common in tumors, including oral squamous cell carcinoma. Cell-in-cell events in oral squamous cell carcinoma are associated with tumor aggressiveness, metastasis, and therapeutic resistance. The lack of standard terminology makes it difficult to classify and understand the behavior and impacts of these structures. Understanding the link between cell-in-cell structures and more aggressive behavior in oral squamous cell carcinoma is crucial for developing effective therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Heinrich Botha, Camile S. Farah, Kendrick Koo, Nicola Cirillo, Michael McCullough, Rita Paolini, Antonio Celentano
Summary: Research shows that in oral squamous cell carcinoma, glucose transporter 1 (GLUT-1) and GLUT-3 expression levels are correlated with tumor stage, treatment resistance, and poor prognosis. Other glucose transporters (GLUTs) are relatively understudied and may have the potential to improve patient care with further analysis.
Article
Microbiology
Wei Wei, Jia Li, Xin Shen, Jinglu Lyu, Caixia Yan, Boyu Tang, Wenjuan Ma, Huixu Xie, Lei Zhao, Lei Cheng, Ye Deng, Yan Li
Summary: Periodontitis promotes the development of OSCC by altering the oral bacterial community and tumor immune microenvironment.
Article
Biochemistry & Molecular Biology
Chia-Huei Lee, Yu-Hsin Tsao, Yui-Ping Weng, I-Ching Wang, Yao-Ping Chen, Pin-Feng Hung
Summary: The herbal medicine perilla leaf extract (PLE) has been found to inhibit the viability of oral squamous cell carcinoma (OSCC) cells. The main phenols in PLE, caffeic acid (CA) and rosmarinic acid (RA), were shown to reduce OSCC cell viability in a dose-dependent manner. In addition, chronic treatment with CA and RA increased the sensitivity of OSCC cells to the EGFR tyrosine kinase inhibitor gefitinib and effectively suppressed interleukin-1 beta secretion. These findings suggest that perilla phenols can be used as adjuvant therapies to improve the efficacy of chemotherapy and EGFR-targeted therapy in OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Karin Heidbreder, Katrin Sommer, Maximilian Wiendl, Tanja M. Mueller, Imke Atreya, Kai Hildner, Markus F. Neurath, Sebastian Zundler
Summary: This study investigates the role of non-classical monocytes in large intestinal wound healing. By depleting non-classical monocytes in mice deficient for the transcription factor Nr4a1, the researchers found that wound healing was significantly delayed and there was a reduced presence of macrophages with a wound healing phenotype. The findings suggest that non-classical monocytes are biased towards wound healing macrophages, providing insights into the modulation of intestinal macrophage functions through monocyte recruitment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Purandar Sarkar, Samaresh Malik, Sayantan Laha, Shantanab Das, Soumya Bunk, Jay Gopal Ray, Raghunath Chatterjee, Abhik Saha
Summary: This study identified significant changes in the oral microbial community of Indian oral squamous cell carcinoma (OSCC) patients, with significantly lower bacterial diversity in malignant samples compared to normal counterparts. Genera such as Prevotella, Corynebacterium were enriched in OSCC lesions, while Actinomyces, Sutterella were notably decreased. HPV-16 was significantly associated with OSCC development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Eros Di Giorgio, Liqing Wang, Yan Xiong, Lanette M. Christensen, Tatiana Akimova, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Claudio Brancolini, Ulf H. Beier, Wayne W. Hancock
Summary: The Mads/Mef2 family of transcription factors regulate differentiation in various cell types and are involved in physiological feedback loops. Disruption of their interaction with Hdac9 can lead to the development of pathologic states, including cancer. These transcription factors also indirectly control tumor progression by regulating antitumor immunity, particularly in Treg cells, adding complexity to the study of Treg biology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ecology
Manolito G. Torralba, Gajender Aleti, Weizhong Li, Kelvin Jens Moncera, Yi-Han Lin, Yanbao Yu, Michal M. Masternak, Wojciech Golusinski, Pawel Golusinski, Katarzyna Lamperska, Anna Edlund, Marcelo Freire, Karen E. Nelson
Summary: The study found a higher number of Fusobacteria, Bacteroidetes, and Firmicutes in oral squamous cell carcinoma (OSCC) tumor tissue, with an increase of Prevotella in saliva from OSCC patients and a prevalence of Corynebacterium in healthy subjects. Additionally, adhesion and virulence factors associated with Streptococcus gordonii and Fusobacterium genera were detected in OSCC tissues, suggesting potential biomarkers for disease progression.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rais Ahmed, Satinder P. Singh, Bhagwant R. Mittal, Vidya Rattan, Rahul Parghane, Ashok Utreja
NUCLEAR MEDICINE COMMUNICATIONS
(2016)
Article
Peripheral Vascular Disease
Malapaka Kiranmayi, Venkat R. Chirasani, Prasanna K. R. Allu, Lakshmi Subramanian, Elizabeth E. Martelli, Bhavani S. Sahu, Durairajpandian Vishnuprabu, Rathnakumar Kumaragurubaran, Saurabh Sharma, Dhanasekaran Bodhini, Madhulika Dixit, Arasambattu K. Munirajan, Madhu Khullar, Venkatesan Radha, Viswanathan Mohan, Ajit S. Mullasari, Sathyamangla V. Naga Prasad, Sanjib Senapati, Nitish R. Mahapatra
Editorial Material
Rheumatology
Varun Dhir, Vinay Sagar, Sanjay Bhadada, Mahesh Prakash, Bishan D. Radotra, Vidya Rattan
Article
Cell Biology
Anupam Mittal, Rajni Sharma, Rishikesh Prasad, Ajay Bahl, Madhu Khullar
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2016)
Article
Cell Biology
Gurinder Bir Singh, Satish K. Raut, Sanskriti Khanna, Akhilesh Kumar, Saurabh Sharma, Rishikesh Prasad, Madhu Khullar
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2017)
Review
Dentistry, Oral Surgery & Medicine
M. K. Sannigrahi, R. Sharma, N. K. Panda, M. Khullar
Review
Endocrinology & Metabolism
Madhu Khullar, Balneek Singh Cheema, Satish K. Raut
FRONTIERS IN ENDOCRINOLOGY
(2017)
Article
Cell Biology
M. K. Sannigrahi, Rajni Sharma, Varinder Singh, Naresh K. Panda, Vidya Rattan, Madhu Khullar
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2018)
Review
Endocrinology & Metabolism
Satish K. Raut, Madhu Khullar
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Multidisciplinary Sciences
Anupam Mittai, Santanu Rana, Rajni Sharma, Akhilesh Kumar, Rishikesh Prasad, Satish K. Raut, Sagartirtha Sarkar, Uma Nahar Saikia, Ajay Bahl, Perundurai S. Dhandapany, Madhu Khullar
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Medicinal
Akshay Kapadia, Krishna K. Sharma, Indresh Kumar Maurya, Varinder Singh, Madhu Khullar, Rahul Jain
Summary: The synthesis of tetrapeptides based on the C-terminus fragment of A beta peptide showed promising protection against A beta aggregation-mediated neurotoxicity in PC-12 cells, with enhanced blood-brain barrier permeability and proteolytic stability. Structural insights and computational studies on ligand-A beta interactions offer new avenues for the advancement of peptide-derived therapeutics for AD.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Satish K. Raut, Madhu Khullar
Summary: Metabolic syndrome is a common condition associated with dyslipidemia, oxidative stress, and other factors, which may lead to complications such as diabetes and heart disease.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Bhawna Rastogi, Amit Kumar, Satish K. Raut, Naresh K. Panda, Vidya Rattan, Nainesh Joshi, Madhu Khullar
CANCER INVESTIGATION
(2017)
Article
Cardiac & Cardiovascular Systems
Gurinder Bir Singh, Sanskriti Khanna, Satish K. Raut, Saurabh Sharma, Rajni Sharma, Madhu Khullar
THERAPEUTIC ADVANCES IN CARDIOVASCULAR DISEASE
(2017)