Review
Oncology
Dandan Guo, Mei Yang, Shiyun Li, Weiwei Zhu, Meixin Chen, Jiayu Pan, Dan Long, Zhaohui Liu, Chunlin Zhang
Summary: Head and neck squamous cell carcinoma (HNSCC) is closely related to persistent HPV infection, and the incidence of HPV-positive HNSCC has been increasing. The main viral oncoproteins E6 and E7 play important roles in malignant transformation, cell proliferation promotion, and tumor invasion. HPV-positive HNSCC shows specific clinical-pathological features, possibly related to HPV infection and specific regulatory mechanisms. Non-coding RNA (ncRNA) plays a critical regulatory role in HPV-induced tumorigenesis and progression. Understanding the expression profile and regulatory role of ncRNAs can provide insights into the carcinogenesis mechanism and valuable biomarkers for HPV-positive HNSCC.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Review
Otorhinolaryngology
Juliana Carron, Caroline Torricelli, Janet K. Silva, Gabriela S. R. Queiroz, Manoela M. Ortega, Carmen S. P. Lima, Gustavo J. Lourenco
Summary: Head and neck squamous cell carcinoma (HN SCC) is the eighth most common cancer worldwide. In addition to tobacco and alcohol consumption, genetic and epigenetic alterations play a critical role in the occurrence and progression of HNSCC. microRNAs (miRNAs) are small noncoding RNAs that regulate various cellular processes and have the potential to serve as diagnostic markers and therapeutic targets for HNSCC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Gasper Grubelnik, Emanuela Bostjancic, Aleksandar Anicin, Tadej Dovsak, Nina Zidar
Summary: The study revealed that in the development of oral squamous cell carcinoma (OSCC), NANOG, miR-145, RoR, and SNHG1 are up-regulated, while TP53 and miR-34a are down-regulated, with AB209630 showing variable expression. NANOG protein is up-regulated early in cancerogenesis, correlating with miR-145 and RoR.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lin Chen, Zhimou Cai, Kexing Lyu, Zhiwei Cai, Wenbin Lei
Summary: The risk score model established based on DEirlncRNA pairs can accurately predict the overall survival of HNSCC patients, aiding in personalized treatment. Compared with other lncRNA signatures, this model performs better and is correlated with the immune microenvironment and chemosensitivity in HNSCC.
Review
Genetics & Heredity
Surabhi Suchanti, Bjorn J. Stephen, Sonali Awasthi, Sudhir K. Awasthi, Gyanendra Singh, Abhijeet Singh, Rajeev Mishra
Summary: This review examines the role of histone epigenetic modifications in head and neck squamous cell carcinoma (HNSCC) and explores the relationships between human papillomavirus oncoproteins and histone-modifying agents. It also discusses the potential of using these modifications as biomarkers for drug treatments.
Article
Biochemistry & Molecular Biology
Jiang Li, Tan Wu, Kai Song, Lina Zhu, Yijuan Wang, Tingting Chen, Xin Wang
Summary: Head and neck squamous cell carcinoma (HNSC) is a common malignancy with high mortality worldwide. Recent studies have identified multiple molecular subtypes of HNSC, and in this study, a network-based bioinformatics framework was used to investigate the subtype-specific regulatory mechanisms. A key regulator called LNCOG was identified, which is associated with the mesenchymal subtype of HNSC and plays a role in promoting cancer progression. The findings provide potential biomarkers for optimized treatment of HNSC.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Mingzhu Zhou, Mingyu Mao, Fan Yang, Tao Zhou, Liuqing Zhou, Yuncheng Li
Summary: This study identified lncRNA AL161431.1 as a reliable prognostic marker for head and neck squamous cell carcinoma (HNSCC), as its high expression correlated with poor survival. Functional enrichment analysis suggested that AL161431.1 may play a role in tumor development and the tumor microenvironment. Further analysis demonstrated a positive association between AL161431.1 expression and M0 macrophage infiltration in HNSCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Qiu-Shuang Xu, Zheng-Zhong Shen, Ling-Qing Yuan
Summary: This study developed a novel prediction model based on cuproptosis-related lncRNAs, which can evaluate survival and tumor immunity in patients with HNSCC and predict the efficacy of immunotherapy and targeted therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Juliette Mainguene, Sophie Vacher, Maud Kamal, Abderaouf Hamza, Julien Masliah-Planchon, Sylvain Baulande, Sabrina Ibadioune, Edith Borcoman, Wulfran Cacheux, Valentin Calugaru, Laura Courtois, Carole Crozes, Marc Deloger, Elodie Girard, Jean-Pierre Delord, Antoine Dubray-Vautrin, Linda Larbi Cherif, Celia Dupain, Emmanuelle Jeannot, Jerzy Klijanienko, Sonia Lameiras, Charlotte Lecerf, Anouchka Modesto, Alain Nicolas, Roman Rouzier, Esma Saada-Bouzid, Pierre Saintigny, Anne Sudaka, Nicolas Servant, Christophe Le Tourneau, Ivan Bieche
Summary: The study found that HPV integration is associated with overexpression of certain cancer genes (such as PDL1 and MYC) in HNSCC patients. This may indicate a role of HPV integration in the carcinogenesis of HNSCC.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ji Yin, Xiaohui Li, Caifeng Lv, Xian He, Xiaoqin Luo, Sen Li, Wenjian Hu
Summary: This study developed an immune-related lncRNA model for risk assessment and prognosis prediction in HNSCC patients, which effectively differentiated between low- and high-risk groups in terms of survival, clinico-pathological characteristics, tumor immune infiltrating status, chemotherapeutics sensitivity, and immunosuppressive molecules. A 13-irlncRNA-pair signature was built and showed high sensitivity and specificity for survival prediction, with the high-risk group exhibiting significantly poorer survival rates and negative relationships with immune infiltrations. Moreover, differences in chemotherapeutics sensitivity and molecular marker expression levels were also observed between high- and low-risk groups.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Pathology
Gianluca Businello, Matteo Fassan, Silvia Degasperi, Giulia Traverso, Melania Scarpa, Imerio Angriman, Andromachi Kotsafti, Ignazio Castagliuolo, Marta Sbaraglia, Romeo Bardini, Marco Scarpa
Summary: The study suggests that HPV infection is not a factor associated with esophageal squamous cell carcinoma (ESCC) after head and neck squamous cell carcinoma (HNSCC). Instead, p53 overexpression is common in HNSCC-associated ESCCs. The altered immune microenvironment, characterized by dysregulated lymphomonocytic infiltration, may play a crucial role in the development of metachronous ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Masato Mima, Atsushi Okabe, Takayuki Hoshii, Takuya Nakagawa, Tomoya Kurokawa, Satoru Kondo, Harue Mizokami, Masaki Fukuyo, Ryoji Fujiki, Bahityar Rahmutulla, Tomokazu Yoshizaki, Toyoyuki Hanazawa, Kiyoshi Misawa, Atsushi Kaneda
Summary: Human papillomavirus (HPV) plays a causal role in the development of head and neck squamous cell carcinoma (HNSCC) by integrating into the host genome and causing genomic alterations. This study analyzed the epigenome, transcriptome, and interactome of HPV-positive HNSCCs to understand the role of epigenetic dysregulation in tumorigenesis. The results showed that genes neighboring HPV integration sites were upregulated and correlated with oncogenic phenotypes in HPV-positive HNSCCs. The epigenetic activation of HPV-interacting regions (HPVIRs) contributed to the genesis of HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cell Biology
Qiuxu Wang, Weiwei Yang, Wei Peng, Xuemei Qian, Minghui Zhang, Tianzhen Wang
Summary: This study identified a DNA methylation-dysregulated four-lncRNA signature in Head and Neck Squamous Cell Carcinoma (HNSCC), which could be used as an independent prognostic factor and was associated with chemotherapy response. These lncRNAs were found to be related to cell differentiation, tissue development, and immune-related pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Xiao Han, Ruxian Tian, Cai Wang, Yumei Li, Xicheng Song
Summary: This review systematically summarizes the regulatory mechanisms of circular RNA (CircRNA) in head and neck squamous cell carcinoma (HNSCC), and explores its functions in tumor growth, cell death, angiogenesis, invasion, and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Applied
Naimat K. Bari, Shaswat Barua, Ankush Garg, Malay K. Sannigrahi, Sharmistha Sinha
CARBOHYDRATE POLYMERS
(2018)
Article
Cell Biology
M. K. Sannigrahi, Rajni Sharma, Varinder Singh, Naresh K. Panda, Vidya Rattan, Madhu Khullar
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2018)
Meeting Abstract
Oncology
Madhu Khullar, Varinder Singh, Nilambra Dogra, Malay Sannigrahi, Naresh Panda
Article
Oncology
Malay K. Sannigrahi, Cheerneni S. Srinivas, Nilesh Deokate, Sabyasachi Rakshit
MOLECULAR ONCOLOGY
(2019)
Article
Biophysics
Ankush Garg, Jagadish Prasad Hazra, Malay Kumar Sannigrahi, Sabyasachi Rakshit, Sharmistha Sinha
BIOPHYSICAL JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Gayathri S. Singaraju, Amin Sagar, Anuj Kumar, Jesse S. Samuel, Jagadish P. Hazra, Malay K. Sannigrahi, Ragothaman M. Yennamalli, Ashish, Sabyasachi Rakshit
Article
Chemistry, Medicinal
Akshay Kapadia, Krishna K. Sharma, Indresh Kumar Maurya, Varinder Singh, Madhu Khullar, Rahul Jain
Summary: The synthesis of tetrapeptides based on the C-terminus fragment of A beta peptide showed promising protection against A beta aggregation-mediated neurotoxicity in PC-12 cells, with enhanced blood-brain barrier permeability and proteolytic stability. Structural insights and computational studies on ligand-A beta interactions offer new avenues for the advancement of peptide-derived therapeutics for AD.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Satish K. Raut, Madhu Khullar
Summary: Metabolic syndrome is a common condition associated with dyslipidemia, oxidative stress, and other factors, which may lead to complications such as diabetes and heart disease.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Malay K. Sannigrahi, Pavithra Rajagopalan, Ling Lai, Xinyi Liu, Varun Sahu, Hiroshi Nakagawa, Jalal B. Jalaly, Robert M. Brody, Iain M. Morgan, Bradford E. Windle, Xiaowei Wang, Phyllis A. Gimotty, Daniel P. Kelly, Elizabeth A. White, Devraj Basu
Summary: Therapy with radiation plus cisplatin kills HPV+ oropharyngeal squamous cell carcinomas (OPSCCs) by increasing reactive oxygen species beyond cellular antioxidant capacity. However, this standard treatment fails for some patients, and this study explores the potential role of HPV oncoprotein levels in affecting mitochondrial metabolism and treatment resistance. The results show that higher levels of the HPV oncoprotein fl-E6 are associated with reduced oxidative phosphorylation, antioxidant capacity and therapy resistance. Ectopically expressing fl-E6 in models with low baseline levels further depletes mitochondrial mass, sensitizes to therapy, and represses the alpha pathway for mitochondrial biogenesis. Clinical data supports these findings, with tumors expressing lower levels of fl-E6 displaying higher p53 target gene expression and an activated PGC-1 alpha/ERR alpha pathway, as well as reduced patient survival. These findings suggest that low levels of the HPV oncoprotein E6 can negatively affect treatment response and patient survival, and highlight the importance of considering the E6- PGC-1 alpha/ERR alpha axis in predicting and targeting treatment resistance in OPSCC.
Meeting Abstract
Oncology
Malay K. Sannigrahi, Pavithra Rajagopalan, Ling Lai, Xinyi Liu, Varun Sahu, Hiroshi Nakagawa, Robert Brody, Iain M. Morgan, Bradford E. Windle, Xiaowei Wang, Phyllis A. Gimotty, Daniel P. Kelly, Elizabeth A. White, Devraj Basu
Article
Oncology
Jaimanti Bakshi, Atul Kumar Goyal, Virender Singh, Malay Sannigrahi, Madhu Khullar
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2020)
Article
Oncology
M. K. Sannigrahi, Rajni Sharma, Varinder Singh, Naresh K. Panda, Vidya Rattan, Madhu Khullar
CLINICAL CANCER RESEARCH
(2017)
