Article
Endocrinology & Metabolism
Bo Wang, Saima Khan, Pengtao Wang, Xiaofang Wang, Yangxi Liu, Jingjing Chen, Xiaolin Tu
Summary: The small molecule CHIR99021 (C91) has been found to promote osteoblast differentiation and mineralization by activating the canonical Wnt signaling pathway and inducing autophagy. In addition, a C91 slow-release hydrogel has been developed for in vivo detection of C91 in the osteogenesis process.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Cong-hui Zhang, Hong Liu, Wu-li Zhao, Wen-xia Zhao, Hui-min Zhou, Rong-guang Shao
Summary: The study revealed that G3BP1 is upregulated and correlated with poor prognosis in breast cancer. Overexpression of G3BP1 promotes breast cancer cell proliferation by stimulating beta-catenin signaling. G3BP1 interacts with GSK-3 beta to inhibit beta-catenin degradation, thus enhancing the proliferative capacity of breast cancer cells.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Qing Song, Zhifen Han, Xinnan Wu, Yan Wang, Lihong Zhou, Liu Yang, Ningning Liu, Hua Sui, Jianfeng Cai, Qing Ji, Qi Li
Summary: In colorectal cancer (CRC), beta-arrestin1 promotes migration and metastasis of CRC cells by regulating the EMT process through the Wnt/β-catenin signaling pathways. This provides a novel therapeutic target for CRC metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hui Liu, Mangaladoss Fredimoses, Peijia Niu, Tingting Liu, Yan Qiao, Xueli Tian, Xiaobing Chen, Dong Joon Kim, Xiang Li, Kangdong Liu, Zigang Dong
Summary: EPRS is frequently overexpressed in GC tissues and its overexpression is associated with poor prognosis in GC patients. High expression of EPRS positively correlates with GC development both in vitro and in vivo by enhancing the WNT/GSK-3 beta/beta-catenin signaling pathway. XA and 4-HD can directly bind to EPRS to block this signaling pathway and inhibit gastric cancer growth.
Article
Integrative & Complementary Medicine
Xiaojiao Fan, Jing Chen, Yajun Zhang, Siyi Wang, Wenqian Zhong, Huipu Yuan, Xia Wu, Chaochen Wang, Yixin Zheng, Yuan Wei, Ying Xiao
Summary: This study clarified the mechanism by which Alpinetin (AP) promotes hair regeneration by activating HFSCs via Wnt signaling. These findings may contribute to the development of a new generation of pilatory that is more efficient and less cytotoxic for treating alopecia.
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Yun-Nan Lin, Keng-Fan Liu, Chun-Ting Wang, Savitha Ramachandran, Ching-Jen Wang, Yur-Ren Kuo
Summary: This study demonstrated that both ESWT and BIO treatment significantly promoted diabetic wound healing and were associated with the GSK-3 beta-mediated Wnt/beta-catenin signaling pathway.
Article
Pharmacology & Pharmacy
Ilandarage Menu Neelaka Molagoda, Chang-Hee Kang, Mi-Hwa Lee, Yung Hyun Choi, Chang-Min Lee, Seungheon Lee, Gi-Young Kim
Summary: Fisetin enhances osteogenic activity, promotes vertebral formation in zebrafish larvae, inhibits anti-osteoblastic genes induced by prednisolone, and activates the GSK-3 beta/beta-catenin signaling pathway to stimulate osteogenesis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Caibing Wang, Kai Zang, Zexin Tang, Ting Yang, Xiyun Ye, Yongyan Dang
Summary: Hordenine enhances the activity of mouse dermal-papilla cells and promotes hair regrowth through activating the Wnt/β-catenin signaling pathway, suggesting its potential use in preventing and treating alopecia.
Article
Integrative & Complementary Medicine
Jian-Qiang Wang, Yu Dong, Zi-Meng Feng, Mei-Ling Fan, Jia-Yu Yang, Jun-Nan Hu, En-Bo Cai, Hong-Yan Zhu, Wei Li, Zi Wang
Summary: This study conducted a series of experiments in vivo and in vitro to investigate the protective effects and possible mechanisms of ginsenoside Re (G-Re) against chemotherapy-induced intestinal damage. The results showed that G-Re improved oxidative damage, cytotoxicity, and apoptosis caused by cisplatin, and inhibited the activation of Wnt/β-catenin signaling. Therefore, G-Re may be a potential candidate drug for the treatment of intestinal injury.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Neurosciences
Yinhong Zhang, Jinghui Yang, Yanling Gong, Shan He, Ping Wen, Yan Jiang, Jing He, Baosheng Zhu, Li Li
Summary: This study investigated the effects of curcumin on the synaptic development of rat hippocampal neurons. It was found that curcumin increased the number of synapses and promoted neurodevelopment. The mechanism involved the inhibition of GSK-3 beta and protection of beta-catenin activity by curcumin. This alleviated oxidative damage caused by thyroxine deficiency.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huawei Tuo, Xuemei Li, Haixia Du, Man Li, Chenli Xu, Zizhong Yu, Huzi Zhao
Summary: FOLR1 is overexpressed in laryngeal squamous cell carcinoma and promotes tumor cell proliferation and migration by enhancing the stability and nuclear translocation of beta-catenin through the EGFR/AKT/GSK3 beta axis.
MOLECULAR CARCINOGENESIS
(2023)
Article
Plant Sciences
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Ilandarage Menu Neelaka Molagoda, Kyoung Tae Lee, Yung Hyun Choi, Cheng-Yun Jin, Gi-Young Kim
Summary: AHs stimulate osteogenic activities through the inhibition of GSK-3 beta and subsequent activation of beta-catenin, leading to anti-osteoporosis effects. This study also found that AHs accelerated vertebral formation and mineralization in zebrafish larvae, highlighting its potential therapeutic effects for osteoporosis.
Article
Cell Biology
Liyan Wang, Bin Li, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng, Lei Ma
Summary: This study revealed that circ_SMAD4 promotes gastric cancer tumorigenesis by activating the CTNNB1-dependent Wnt/beta-catenin pathway. The mechanism involves nuclear circ_SMAD4 recruiting TCF4 to facilitate CTNNB1 transcription, while cytoplasmic circ_SMAD4 sequestering miR-1276 to prevent CTNNB1 mRNA silencing. Rescue experiments confirmed that circ_SMAD4 accelerates GC cell growth through the miR-1276/TCF4-regulated CTNNB1 pathway.
CELL PROLIFERATION
(2021)
Article
Pharmacology & Pharmacy
Chun-Lan Xie, Yu-Ting Yue, Jing-Ping Xu, Na Li, Ting Lin, Guang-Rong Ji, Xian-Wen Yang, Ren Xu
Summary: This study investigated the potential of lead compounds from deep-sea-derived Penicillium solitum to promote bone formation for osteoporosis treatment. Penicopeptide A (PPA) was found to enhance osteoblast mineralization in bone marrow mesenchymal stem cells (BMSCs). Further experiments demonstrated that PPA promoted osteogenic differentiation and inhibited adipogenic differentiation of BMSCs, with no effect on chondrogenic differentiation. Mechanistic studies revealed that PPA activated the AKT, GSK-3 beta, and beta-catenin signaling pathways. In a mouse model of ovariectomy-induced bone loss, PPA treatment prevented bone volume and trabecular thickness decreases. These results suggest that PPA has clinical potential as a candidate compound for osteoporosis prevention.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Cell Biology
Bei Tao, Yi Song, Yao Wu, Xiaobo Yang, Tangming Peng, Lilei Peng, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Chuanhong Zhong
Summary: This study found that a stiffer matrix can promote the stemness of glioma cells by activating the BCL9L/Wnt/beta-catenin signaling pathway. Additionally, gigantol can enhance the effectiveness of traditional chemotherapy and radiotherapy by inhibiting Wnt/beta-catenin signaling, providing a potential strategy for clinical treatment of gliomas.
