Selective Activation of a TRPC6 Ion Channel Over TRPC3 by Metalated Type-B Polycyclic Polyprenylated Acylphloroglucinols

Ins and outs of AlphaFold2 transmembrane protein structure predictions

(2022) Tamás Hegedűs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs

(2022) Yamina El Hamdaoui et al.   MOLECULAR PSYCHIATRY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6

(2021) Pei-Lin Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The trRosetta server for fast and accurate protein structure prediction

(2021) Zongyang Du et al.   Nature Protocols

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

TRPC channels: Structure, function, regulation and recent advances in small molecular probes

(2020) Hongbo Wang et al.   PHARMACOLOGY & THERAPEUTICS

Structural basis for pharmacological modulation of the TRPC6 channel

(2020) Yonghong Bai et al.   eLife

Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature

(2020) Nathaniel J. Himmel et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The structure of TRPC ion channels

(2019) Jian Li et al.   CELL CALCIUM

Deep learning extends de novo protein modelling coverage of genomes using iteratively predicted structural constraints

(2019) Joe G. Greener et al.   Nature Communications

Structure of the receptor-activated human TRPC6 and TRPC3 ion channels

(2018) Qinglin Tang et al.   CELL RESEARCH

Research Progress of Polycyclic Polyprenylated Acylphloroglucinols

(2018) Xing-Wei Yang et al.   CHEMICAL REVIEWS

Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6)

(2018) Caleigh M. Azumaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the human lipid-gated cation channel TRPC3

(2018) Chen Fan et al.   eLife

The EVcouplings Python framework for coevolutionary sequence analysis

(2018) Thomas A Hopf et al.   BIOINFORMATICS

Computed Regioselectivity and Conjectured Biological Activity of Ene Reactions of Singlet Oxygen with the Natural Product Hyperforin

(2017) Inna Abramova et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

The enantioselective total synthesis of (+)-clusianone

(2015) Fiene Horeischi et al.   CHEMICAL COMMUNICATIONS

Total Synthesis and Absolute Configuration Assignment of MRSA Active Garcinol and Isogarcinol

(2014) Cecilia Socolsky et al.   CHEMISTRY-A EUROPEAN JOURNAL

More Than a Pore: Ion Channel Signaling Complexes

(2014) A. Lee et al.   JOURNAL OF NEUROSCIENCE

The Total Syntheses of Guttiferone A and 6-epi-Guttiferone A

(2014) Fiene Horeischi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Bidirectional Total Synthesis of Sampsonione P and Hyperibone I

(2013) Katharina Lindermayr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling

(2013) Jeanine H. Heiser et al.   JOURNAL OF NEUROCHEMISTRY

In vivo photoprotective and anti-inflammatory effect of hyperforin is associated with high antioxidant activity in vitro and ex vivo

(2012) Martina C. Meinke et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca2+-permeable TRPC6 channels

(2012) Kristina Leuner et al.   HIPPOCAMPUS

DAG-sensitive and Ca2+permeable TRPC6 channels are expressed in dentate granule cells and interneurons in the hippocampal formation

(2012) Gergő A. Nagy et al.   HIPPOCAMPUS

EXTRACTION OF HYPERFORIN AND HYPERICIN FROM ST. JOHN'S WORT (HYPERICUM PERFORATUM L.) WITH DIFFERENT SOLVENTS

(2011) DÁNIEL COSSUTA et al.   JOURNAL OF FOOD PROCESS ENGINEERING

The total synthesis of hyperpapuanone, hyperibone L, epi-clusianone and oblongifolin A

(2011) Nicole Biber et al.   Nature Chemistry

Reduced TRPC Channel Expression in Psoriatic Keratinocytes Is Associated with Impaired Differentiation and Enhanced Proliferation

(2011) Kristina Leuner et al.   PLoS One

Critical role of TRPC6 channels in the formation of excitatory synapses

(2008) Jian Zhou et al.   NATURE NEUROSCIENCE