Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs
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Title
Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs
Authors
Keywords
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Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume -, Issue -, Pages -
Publisher
American Chemical Society (ACS)
Online
2023-11-06
DOI
10.1021/acs.jmedchem.3c01026
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Note: Only part of the references are listed.- Sodium-Dependent Neutral Amino Acid Transporter 2 Can Serve as a Tertiary Carrier for l-Type Amino Acid Transporter 1-Utilizing Prodrugs
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- dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts
- (2022) Vadim Demichev et al. Nature Communications
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- (2022) Ahmed B. Montaser et al. LIFE SCIENCES
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- (2022) Arun Kumar Tonduru et al. MOLECULES
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- (2021) Kamil Mikulášek et al. Frontiers in Plant Science
- Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production
- (2021) Janne Tampio et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Data-Driven Ensemble Docking to Map Molecular Interactions of Steroid Analogs with Hepatic Organic Anion Transporting Polypeptides
- (2021) Alzbeta Tuerkova et al. Journal of Chemical Information and Modeling
- OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space
- (2021) Chao Lu et al. Journal of Chemical Theory and Computation
- Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2
- (2021) Santosh Kumar Adla et al. MOLECULES
- Highly accurate protein structure prediction with AlphaFold
- (2021) John Jumper et al. NATURE
- Single-cell transcriptome profiling of thyroid hormone effectors in the human fetal neocortex: expression of SLCO1C1, DIO2, and THRB in specific cell types
- (2021) Diego Diez et al. THYROID
- AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
- (2021) Mihaly Varadi et al. NUCLEIC ACIDS RESEARCH
- L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood–Brain Barrier and into Human and Mouse Brain Parenchymal Cells
- (2020) Ahmed B. Montaser et al. ACS Chemical Neuroscience
- L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery
- (2019) Elena Puris et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Filter Aided Sample Preparation – A tutorial
- (2019) Jacek R. Wiśniewski ANALYTICA CHIMICA ACTA
- L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)
- (2019) Johanna Huttunen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
- (2019) Vadim Demichev et al. NATURE METHODS
- l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
- (2019) Johanna Huttunen et al. Scientific Reports
- Extracellular Prolyl Oligopeptidase Derived from Activated Microglia is a Potential Neuroprotection Target
- (2018) Teemu A. Natunen et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen
- (2018) K.M. Huttunen BIOORGANIC CHEMISTRY
- Mutated Thyroid Hormone Transporter OATP1C1 Associates with Severe Brain Hypometabolism and Juvenile Neurodegeneration
- (2018) Petter Strømme et al. THYROID
- L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs
- (2017) Elena Puris et al. JOURNAL OF CONTROLLED RELEASE
- Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects
- (2016) Eisuke Miyauchi et al. MOLECULAR PHARMACEUTICS
- Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs
- (2016) Mikko Gynther et al. MOLECULAR PHARMACEUTICS
- Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure
- (2016) Mikko Gynther et al. NEUROCHEMICAL RESEARCH
- Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate
- (2015) Izabel Patik et al. BIOCHEMICAL PHARMACOLOGY
- Amino Acid Residues in the Putative Transmembrane Domain 11 of Human Organic Anion Transporting Polypeptide 1B1 Dictate Transporter Substrate Binding, Stability, and Trafficking
- (2015) Weifang Hong et al. MOLECULAR PHARMACEUTICS
- Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ
- (2014) Jürgen Cox et al. MOLECULAR & CELLULAR PROTEOMICS
- Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
- (2013) G. Madhavi Sastry et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine
- (2013) Lauri Peura et al. PHARMACEUTICAL RESEARCH
- Identification of Amino Acids Essential for Estrone-3-Sulfate Transport within Transmembrane Domain 2 of Organic Anion Transporting Polypeptide 1B1
- (2012) Nan Li et al. PLoS One
- Functional and Structural Relevance of Conserved Positively Charged Lysine Residues in Organic Anion Transporting Polypeptide 1B3
- (2011) K. Mandery et al. MOLECULAR PHARMACOLOGY
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- (2011) Annette Grüters et al. Nature Reviews Endocrinology
- Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3
- (2010) H Glaeser et al. BRITISH JOURNAL OF PHARMACOLOGY
- Evidence of Evolutionary Conservation of Function between the Thyroxine Transporter Oatp1c1 and Major Facilitator Superfamily Members
- (2010) Daniel E. Westholm et al. ENDOCRINOLOGY
- Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters
- (2009) Simone Leuthold et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The Blood-Brain Barrier Thyroxine Transporter Organic Anion-Transporting Polypeptide 1c1 Displays Atypical Transport Kinetics
- (2009) Daniel E. Westholm et al. ENDOCRINOLOGY
- Expression of the Thyroid Hormone Transporters Monocarboxylate Transporter-8 (SLC16A2) and Organic Ion Transporter-14 (SLCO1C1) at the Blood-Brain Barrier
- (2008) Lori M. Roberts et al. ENDOCRINOLOGY
- Competitive Inhibition of Organic Anion Transporting Polypeptide 1c1-Mediated Thyroxine Transport by the Fenamate Class of Nonsteroidal Antiinflammatory Drugs
- (2008) Daniel E. Westholm et al. ENDOCRINOLOGY
- Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family
- (2008) B. Hagenbuch et al. XENOBIOTICA
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