NovelTFGmutation causes autosomal-dominant spastic paraplegia and defects in autophagy

Expanding the TDP-43 Proteinopathy Pathway From Neurons to Muscle: Physiological and Pathophysiological Functions

(2022) Lauren Versluys et al.   Frontiers in Neuroscience

Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases

(2022) Takeshi Yamamotoya et al.   Scientific Reports

TFG mutation induces haploinsufficiency and drives axonal Charcot–Marie–Tooth disease by causing neurite degeneration

(2022) Xihui Chen et al.   CNS Neuroscience & Therapeutics

TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance

(2022) Jennifer L. Peotter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFG binds LC3C to regulate ULK1 localization and autophagosome formation

(2021) Marianna Carinci et al.   EMBO JOURNAL

A Novel TFG Mutation in a Korean Family with α‐Synucleinopathy and Amyotrophic Lateral Sclerosis

(2021) Dallah Yoo et al.   MOVEMENT DISORDERS

Presence of colocalised phosphorylated TDP-43 and TFG proteins in the frontotemporal lobes of HMSN-P

(2020) Kengo Maeda et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

COPII‐mediated trafficking at the ER/ERGIC interface

(2019) Jennifer Peotter et al.   TRAFFIC

Muscle pathology of hereditary motor and sensory neuropathy with proximal dominant involvement with TFG mutation

(2019) Satoshi Yamashita et al.   MUSCLE & NERVE

TFG : At the crossroads of motor neuron disease and myopathy

(2019) Stefan Nicolau et al.   MUSCLE & NERVE

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

(2019) Fumiaki Mori et al.   Acta Neuropathologica Communications

R106C TFG variant causes infantile neuroaxonal dystrophy “plus” syndrome

(2018) A. Catania et al.   NEUROGENETICS

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

(2018) Matthew D. Cykowski et al.   Acta Neuropathologica Communications

Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation

(2018) Erin L. Slosarek et al.   Cell Reports

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER–Golgi intermediate compartments

(2017) Michael G. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome impairment in neural cells derived from HMSN-P patient iPSCs

(2017) Nagahisa Murakami et al.   Molecular Brain

Novel Genetic, Clinical, and Pathomechanistic Insights into TFG-Associated Hereditary Spastic Paraplegia

(2016) Gaurav V. Harlalka et al.   HUMAN MUTATION

TFG-Related Neurologic Disorders: New Insights Into Relationships Between Endoplasmic Reticulum and Neurodegeneration

(2016) Takuya Yagi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization

(2015) A. Johnson et al.   EMBO JOURNAL

HMSN-P caused by p.Pro285Leu mutation in TFG is not confined to patients with Far East ancestry

(2015) Afagh Alavi et al.   NEUROBIOLOGY OF AGING

Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin–proteasome system

(2014) Takuya Yagi et al.   NEUROBIOLOGY OF DISEASE

A novel TFG mutation causes Charcot-Marie-Tooth disease type 2 and impairs TFG function

(2014) P.-C. Tsai et al.   NEUROLOGY

Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure

(2013) C. Beetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TRK-Fused Gene Is Mutated in Hereditary Motor and Sensory Neuropathy with Proximal Dominant Involvement

(2012) Hiroyuki Ishiura et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Expression and Localization of TRK-Fused Gene Products in the Rat Brain and Retina

(2011) Hisae Maebayashi et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

TFG-1 function in protein secretion and oncogenesis

(2011) Kristen Witte et al.   NATURE CELL BIOLOGY

In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments

(2010) C. D'Agostino et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia

(2008) C C Weihl et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY