TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance

Bioinformatic identification of previously unrecognized amyloidogenic proteins

(2022) Gregory M. Rosenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases

(2022) Takeshi Yamamotoya et al.   Scientific Reports

Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR

(2022) Mireia Perez Verdaguer et al.   Cell Reports

Lysosome Function and Dysfunction in Hereditary Spastic Paraplegias

(2021) Daisy Edmison et al.   Brain Sciences

Brain Damage and Gene Expression Across Hereditary Spastic Paraplegia Subtypes

(2021) Katiane R. Servelhere et al.   MOVEMENT DISORDERS

TFG binds LC3C to regulate ULK1 localization and autophagosome formation

(2021) Marianna Carinci et al.   EMBO JOURNAL

Homozygous TFG gene variants expanding the mutational and clinical spectrum of hereditary spastic paraplegia 57 and a review of literature

(2021) Mehdi Khorrami et al.   JOURNAL OF HUMAN GENETICS

Upper Motor Neuron Disorders: Primary Lateral Sclerosis, Upper Motor Neuron Dominant Amyotrophic Lateral Sclerosis, and Hereditary Spastic Paraplegia

(2021) Timothy Fullam et al.   Brain Sciences

Corticospinal vs Rubrospinal Revisited: An Evolutionary Perspective for Sensorimotor Integration

(2021) Rafael Olivares-Moreno et al.   Frontiers in Neuroscience

A Novel TFG Mutation in a Korean Family with α‐Synucleinopathy and Amyotrophic Lateral Sclerosis

(2021) Dallah Yoo et al.   MOVEMENT DISORDERS

Insights into Clinical, Genetic, and Pathological Aspects of Hereditary Spastic Paraplegias: A Comprehensive Overview

(2021) Liena E. O. Elsayed et al.   Frontiers in Molecular Biosciences

Genetic architecture of motor neuron diseases

(2021) Rishabh Chaudhary et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

In vitro Models of Neurodegenerative Diseases

(2020) Anna Slanzi et al.   Frontiers in Cell and Developmental Biology

Presence of colocalised phosphorylated TDP-43 and TFG proteins in the frontotemporal lobes of HMSN-P

(2020) Kengo Maeda et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits

(2020) André T. Lopes et al.   PLOS BIOLOGY

Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway

(2020) Gabriele Colozza et al.   Scientific Reports

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

Neuroimaging in Hereditary Spastic Paraplegias: Current Use and Future Perspectives

(2019) Felipe Franco da Graça et al.   Frontiers in Neurology

Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM

(2019) Yilin Tai et al.   NEURON

New Hypothesis for the Etiology of SPAST‐ based Hereditary Spastic Paraplegia

(2019) Liang Qiang et al.   Cytoskeleton

COPII‐mediated trafficking at the ER/ERGIC interface

(2019) Jennifer Peotter et al.   TRAFFIC

Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions

(2019) Rocco Pizzarelli et al.   NEUROSCIENCE

Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons

(2019) Baris Genc et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Imbalanced Corticospinal and Reticulospinal Contributions to Spasticity in Humans with Spinal Cord Injury

(2019) Sina Sangari et al.   JOURNAL OF NEUROSCIENCE

Muscle pathology of hereditary motor and sensory neuropathy with proximal dominant involvement with TFG mutation

(2019) Satoshi Yamashita et al.   MUSCLE & NERVE

Membrane Transport at an Organelle Interface in the Early Secretory Pathway: Take Your Coat Off and Stay a While

(2018) Michael G. Hanna et al.   BIOESSAYS

Converging cellular themes for the hereditary spastic paraplegias

(2018) Craig Blackstone   CURRENT OPINION IN NEUROBIOLOGY

R106C TFG variant causes infantile neuroaxonal dystrophy “plus” syndrome

(2018) A. Catania et al.   NEUROGENETICS

DeepLabCut: markerless pose estimation of user-defined body parts with deep learning

(2018) Alexander Mathis et al.   NATURE NEUROSCIENCE

Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation

(2018) Erin L. Slosarek et al.   Cell Reports

Hereditary Spastic Paraplegia: gain-of-function mechanisms revealed by new transgenic mouse

(2018) Liang Qiang et al.   HUMAN MOLECULAR GENETICS

A novel homozygous mutation of the TFG gene in a patient with early onset spastic paraplegia and later onset sensorimotor polyneuropathy

(2018) Takuya Miyabayashi et al.   JOURNAL OF HUMAN GENETICS

Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

(2017) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

TFG associated hereditary spastic paraplegia: an addition to the phenotypic spectrum

(2017) Huma Tariq et al.   NEUROGENETICS

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER–Golgi intermediate compartments

(2017) Michael G. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome impairment in neural cells derived from HMSN-P patient iPSCs

(2017) Nagahisa Murakami et al.   Molecular Brain

Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines

(2017) Aaron B Bowen et al.   eLife

Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity

(2017) Takeshi Yamamotoya et al.   Scientific Reports

High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders

(2016) Daniel F. Preisig et al.   BEHAVIOURAL BRAIN RESEARCH

Genetic and phenotypic characterization of complex hereditary spastic paraplegia

(2016) Eleanna Kara et al.   BRAIN

The corticospinal tract: Evolution, development, and human disorders

(2016) Quentin Welniarz et al.   Developmental Neurobiology

Rodent models in neuroscience research: is it a rat race?

(2016) Bart Ellenbroek et al.   Disease Models & Mechanisms

Hereditary spastic paraplegias: identification of a novel SPG57 variant affecting TFG oligomerization and description of HSP subtypes in Sudan

(2016) Liena E O Elsayed et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein

(2016) Takashi Kanadome et al.   FEBS Journal

Novel Genetic, Clinical, and Pathomechanistic Insights into TFG-Associated Hereditary Spastic Paraplegia

(2016) Gaurav V. Harlalka et al.   HUMAN MUTATION

Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses

(2016) Theofilos Papadopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFG-Related Neurologic Disorders: New Insights Into Relationships Between Endoplasmic Reticulum and Neurodegeneration

(2016) Takuya Yagi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

(2016) Monika S. Brill et al.   NEURON

Quantitative Gait Analysis Using a Motorized Treadmill System Sensitively Detects Motor Abnormalities in Mice Expressing ATPase Defective Spastin

(2016) James W. Connell et al.   PLoS One

TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion

(2016) Janine McCaughey et al.   Cell Reports

TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization

(2015) A. Johnson et al.   EMBO JOURNAL

HMSN-P caused by p.Pro285Leu mutation in TFG is not confined to patients with Far East ancestry

(2015) Afagh Alavi et al.   NEUROBIOLOGY OF AGING

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

(2015) Yong-Bo Hu et al.   Translational Neurodegeneration

Gephyrin: a master regulator of neuronal function?

(2014) Shiva K. Tyagarajan et al.   NATURE REVIEWS NEUROSCIENCE

Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin–proteasome system

(2014) Takuya Yagi et al.   NEUROBIOLOGY OF DISEASE

A novel TFG mutation causes Charcot-Marie-Tooth disease type 2 and impairs TFG function

(2014) P.-C. Tsai et al.   NEUROLOGY

It's All in Your Mind: Determining Germ Cell Fate by Neuronal IRE-1 in C. elegans

(2014) Mor Levi-Ferber et al.   PLoS Genetics

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms

(2013) John K. Fink   ACTA NEUROPATHOLOGICA

A spastic paraplegia mouse model reveals REEP1-dependent ER shaping

(2013) Christian Beetz et al.   JOURNAL OF CLINICAL INVESTIGATION

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

(2013) Christine E. Holt et al.   NEURON

Recombinant Probes for Visualizing Endogenous Synaptic Proteins in Living Neurons

(2013) Garrett G. Gross et al.   NEURON

Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure

(2013) C. Beetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Hereditary Spastic Paraplegia Mouse Model Supports a Role of ZFYVE26/SPASTIZIN for the Endolysosomal System

(2013) Mukhran Khundadze et al.   PLoS Genetics

Proximal Dominant Hereditary Motor and Sensory Neuropathy With Proximal Dominance Association With Mutation in the TRK-Fused Gene

(2013) Sang-Soo Lee et al.   JAMA Neurology

The TRK-Fused Gene Is Mutated in Hereditary Motor and Sensory Neuropathy with Proximal Dominant Involvement

(2012) Hiroyuki Ishiura et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cellular Pathways of Hereditary Spastic Paraplegia

(2012) Craig Blackstone   Annual Review of Neuroscience

Expression and Localization of TRK-Fused Gene Products in the Rat Brain and Retina

(2011) Hisae Maebayashi et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

TFG-1 function in protein secretion and oncogenesis

(2011) Kristen Witte et al.   NATURE CELL BIOLOGY

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents

(2010) Björn Zörner et al.   NATURE METHODS

Hereditary spastic paraplegias: membrane traffic and the motor pathway

(2010) Craig Blackstone et al.   NATURE REVIEWS NEUROSCIENCE

SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum

(2009) C. Goizet et al.   NEUROLOGY

Spastic Hypertonia and Movement Disorders: Pathophysiology, Clinical Presentation, and Quantification

(2009) Geoffrey Sheean et al.   PM&R