Inositol polyphosphate multikinase modulates free fatty acids‐induced insulin resistance in primary mouse hepatocytes

miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling

(2023) Haein Lee et al.   Biomolecules

Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis

(2023) Luke Reilly et al.   iScience

Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice

(2022) Sung-E Choi et al.   JOURNAL OF HEPATOLOGY

IPMK modulates hepatic glucose production and insulin signaling

(2022) Ik‐Rak Jung et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reactive Oxygen Species and Oxidative Stress in the Pathogenesis of MAFLD

(2022) Kathleen Clare et al.   Journal of Clinical and Translational Hepatology

Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis

(2022) Wei Chen et al.   Cell Death & Disease

4-Phenylbutyric acid improves free fatty acid-induced hepatic insulin resistance in vivo

(2021) Sandra Pereira et al.   Endocrine Connections

Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis

(2020) Lynda Aoudjehane et al.   Disease Models & Mechanisms

In Vitro and In Vivo Models of Non-Alcoholic Fatty Liver Disease: A Critical Appraisal

(2020) Pierre-Antoine Soret et al.   Journal of Clinical Medicine

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

(2019) Yong Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

Degradation of splicing factor SRSF3 contributes to progressive liver disease

(2019) Deepak Kumar et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Ceramides in Insulin Resistance

(2019) Emilia Sokolowska et al.   Frontiers in Endocrinology

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Plasma levels of free fatty acids correlate with type 2 diabetes mellitus

(2018) Sandro Spiller et al.   DIABETES OBESITY & METABOLISM

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

(2018) Daniel J. Fazakerley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate-induced ER stress and inhibition of protein synthesis in cultured myotubes does not require Toll-like receptor 4

(2018) Ben D. Perry et al.   PLoS One

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

(2018) Xavier Palomer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CtBP2 ameliorates palmitate-induced insulin resistance in HepG2 cells through ROS mediated JNK pathway

(2017) Pingli Liu et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

The etiology of oxidative stress in insulin resistance

(2017) Samantha Hurrle et al.   Biomedical Journal

Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways

(2016) Rachel Raynes et al.   MOLECULAR ASPECTS OF MEDICINE

Glutamate dehydrogenase activator BCH stimulating reductive amination prevents high fat/high fructose diet-induced steatohepatitis and hyperglycemia in C57BL/6J mice

(2016) Seung Jin Han et al.   Scientific Reports

Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules

(2015) Megumi Ishii et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes

(2014) Myra E. Woodworth-Hobbs et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Duration of rise in free fatty acids determines salicylate's effect on hepatic insulin sensitivity

(2013) Sandra Pereira et al.   JOURNAL OF ENDOCRINOLOGY

Saturated fatty acid palmitate-induced insulin resistance is accompanied with myotube loss and the impaired expression of health benefit myokine genes in C2C12 myotubes

(2013) Ming Yang et al.   Lipids in Health and Disease

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging

(2013) Jenny K. Ngo et al.   Redox Biology

Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase

(2011) Seyun Kim et al.   Cell Metabolism

AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase

(2011) S. Bang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB

(2011) D. Maag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative protein damage and the proteasome

(2010) S. Grimm et al.   AMINO ACIDS

Diacylglycerol-mediated insulin resistance

(2010) Derek M Erion et al.   NATURE MEDICINE

Reactive oxygen species and insulin resistance: the good, the bad and the ugly

(2010) Tony Tiganis   TRENDS IN PHARMACOLOGICAL SCIENCES

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin resistance is a cellular antioxidant defense mechanism

(2009) K. L. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS