Cordycepin remodels the tumor microenvironment of colorectal cancer by down-regulating the expression of PD-L1

A synopsis of modern - day colorectal cancer: Where we stand

(2022) Ranmali Ranasinghe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cordycepin inhibits colon cancer proliferation by suppressing MYC expression

(2022) Zhe Zhang et al.   BMC Pharmacology & Toxicology

Immune phenotypic linkage between colorectal cancer and liver metastasis

(2022) Yedan Liu et al.   CANCER CELL

Cordycepin enhances anti-tumor immunity in colon cancer by inhibiting phagocytosis immune checkpoint CD47 expression

(2022) Qifeng Deng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cancer in sub-Saharan Africa in 2020: a review of current estimates of the national burden, data gaps, and future needs

(2022) Freddie Bray et al.   LANCET ONCOLOGY

WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

(2022) Hirokazu Taniguchi et al.   Cell Reports

TIGIT Blockade Exerts Synergistic Effects on Microwave Ablation Against Cancer

(2022) Yaping Chen et al.   Frontiers in Immunology

Cordycepin (3′-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner

(2022) Su-Chan Lee et al.   Cancers

Cordycepin Inhibits Triple-Negative Breast Cancer Cell Migration and Invasion by Regulating EMT-TFs SLUG, TWIST1, SNAIL1, and ZEB1

(2022) Chunli Wei et al.   Frontiers in Oncology

Cordycepin Inhibits Growth and Metastasis Formation of MDA-MB-231 Xenografts in Nude Mice by Modulating the Hedgehog Pathway

(2022) Wenya Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL1R2 increases regulatory T cell population in the tumor microenvironment by enhancing MHC-II expression on cancer-associated fibroblasts

(2022) Lujun Chen et al.   Journal for ImmunoTherapy of Cancer

Cancer statistics for A merican I ndian and A laska N ative individuals, 2022: Including increasing disparities in early onset colorectal cancer

(2022) Tyler B. Kratzer et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia

(2021) Aldona Kasprzak   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment

(2021) Shaikha AlMusawi et al.   Clinical and Translational Medicine

Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumor regrowth

(2021) Dennis Doleschel et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells

(2021) Suthida Panwong et al.   MOLECULES

Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways

(2021) Yaqi Zhou et al.   Oncology Letters

The Half-Life-Extended IL21 can Be Combined With Multiple Checkpoint Inhibitors for Tumor Immunotherapy

(2021) Shaoxian Wu et al.   Frontiers in Cell and Developmental Biology

PD‑L1 expression increased by IFN‑γ via JAK2‑STAT1 signaling and predicts a poor survival in colorectal cancer

(2020) Tiancheng Zhao et al.   Oncology Letters

Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside

(2020) Darleny Y. Lizardo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin

(2020) Chun-Ting Lee et al.   Frontiers in Pharmacology

Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway

(2019) Chunli Wei et al.   PHARMACOLOGICAL RESEARCH

IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling

(2018) Yi Gao et al.   INTERNATIONAL JOURNAL OF CANCER

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma

(2018) Alexander M.M. Eggermont et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Anticancer Properties of Cordycepin and Their Underlying Mechanisms

(2018) So Yoon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cordycepin induces Bax‑dependent apoptosis in colorectal cancer cells

(2018) Shang‑Ze Li et al.   Molecular Medicine Reports

Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)

(2017) Jacob Schachter et al.   LANCET

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Dual Faces of IFN  in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor Immunity

(2016) M. Mandai et al.   CLINICAL CANCER RESEARCH

The effects of cordycepin on the cell proliferation, migration and apoptosis in human lung cancer cell lines A549 and NCI-H460

(2016) Xiandong Tao et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

BCL2L11/Bim as a dual-agent regulating autophagy and apoptosis in drug resistance

(2015) Yun Dai et al.   Autophagy

Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells

(2015) Yuanhong Liao et al.   CELL CYCLE

Cordycepin-enriched Cordyceps militaris induces immunomodulation and tumor growth delay in mouse-derived breast cancer

(2013) MIN-HO JEONG et al.   ONCOLOGY REPORTS

Cordycepin Inhibits Protein Synthesis and Cell Adhesion through Effects on Signal Transduction

(2009) Ying Ying Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY